Scott R Mackenzie Foundation Inc
Total Giving
$1.0M
Number of Grants
6
Median Grant
$149K
Grant Range
$10K - $400K
| Year | Assets | Total Giving | # Grants | Median Grant |
|---|---|---|---|---|
| 2023 | $14.9M | $1.0M | 6 | $149K |
| 2021 | $14.4M | $939K | 6 | $127K |
| 2020 | $17.0M | $825K | 4 | $188K |
| 2019 | $17.7M | $947K | 3 | $330K |
| 2018 | $18.0M | $1.2M | 5 | $282K |
MAYO CLINIC
THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THIS GIFT TO SUPPORT THE TAPESTRY STUDY.
4500 SAN PABLO RD S - JACKSONVILLE - FL 32224 • 2021
$10K
UNIVERSITY OF FLORIDA FOUNDATION
THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO BROADEN THE DISCOVERY OF NEW PANCREATIC CANCER BIOMARKERS THROUGH GENOMIC SEQUENCING. BY SEQUENCING TUMOR AND NORMAL SAMPLES FROM OUR PATIENTS, WE CAN DETERMINE NOVEL CANCER DRIVERS INCLUDING MUTATIONS, FUSIONS, AND GENE EXPRESSION ALTERATIONS THAT DRIVE THESE CANCERS. NEW BIOMARKERS WILL INTRODUCE NEW POTENTIAL TARGETS FOR TREATMENT AND EARLY DETECTIONS.
PO BOX 14425 - GAINESVILLE - FL 32604 • 2021
$150K
UNIVERSITY OF FLORIDA FOUNDATION
THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO ASSESS POTENTIAL DRUG INTERACTIONS BETWEEN CANGRELOR AND NOVEL P2Y12 INHIBITORS AND EVALUATE THE IMPACT OF RECEPTOR EXPRESSION ON THEIR FINDINGS.
PO BOX 14425 - GAINESVILLE - FL 32604 • 2021
$125K
ISRAEL CANCER RESEARCH FUND
THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO ASK HOW DNA REPAIR IS ORCHESTRATED DESPITE THE PACKAGING OF DNA INTO CHROMATIN. SWI/SNF PROTEINS ESTABLISH AND MAINTAIN CHROMATIN STRUCTURE. SUBUNITS OF SWI/SNF PROTEINS ARE MUTATED IN 20% OF CANCERS, IMPLICATING THEM IN CARCINOGENESIS, AND MAKING THEM ATTRACTIVE CANDIDATES FOR CANCER-SPECIFIC AND SELECTIVE THERAPIES. DR. ADAR EXPECTS TO ESTABLISH THAT SWI/SNF REMODELERS FACILITATE SPECIFIC STEPS IN NUCLEOTIDE EXCISION REPAIR (NER) IN CHROMATIN TEMPLATES, AND THAT CANCER ASSOCIATED MUTANTS ARE DEFICIENT IN THIS FUNCTION. THIS NEW UNDERSTANDING OF SWI/SNF FUNCTIONS CAN THEN BE LEVERAGED TO DESIGN NEW CANCER DIAGNOSTICS AND CHEMOTHERAPEUTICS.
52 VANDERBILT AVE SUITE 1510 - NEW YORK - NY 10017 • 2021
$149K
MOUNT DESERT ISLAND BIOLOGICAL LABORATORY
THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO PREVENT ORGAN COMPLICATIONS IN DIABETIC PATIENTS. HIGH GLUCOSE LEVELS LEAD TO THE PATHALOGICAL CHANGES IN THE VASCULATURE OF DIFFERENT ORGANS SUCH AS THE HEART, KIDNEY, EYE AND PERIPHERAL CIRCULATION. THE FOCUS IS THE MICROCIRCULATION OF THE KIDNEY. THE ENDOTHELIAL CELL SURFACE IS COVERED WITH A LAYER OF GLYCOCALYX. THE GLYCOCALYX IS VERY IMPORTANT FOR THE HEALTH OF THE VASCULAR WALL AND REGULATES CENTRAL MECHANISMS SUCH AS METABOLISM, INFLAMMATION, BLOOD PRESSURE, ETC. WE WILL TEST THE HYPOTHESIS THAT RECOMBINANT HPA2 AMELIORATES DIABETIC NEPHROPATHY BY MAINTAINING A FUNCTIONAL HEPARAN SULFATE GLYCOCALYX ON ENDOTHELIAL CELLS AND MONOCYTES.
159 OLD BAR HARBOR RD - BAR HARBOR - ME 04609 • 2021
$400K
UNIVERSITY OF ARIZONA
THE BENEFACTOR DESIRES THAT GRANTEE SHALL USE THE GIFT TO IMPROVE THE DIAGNOSIS AND TREATMENT OF ATRIAL FIBRILLATION. TO DEVELOP PATIENT-SPECIFIC TARGETED NEXT-GENERATION GENE SEQUENCING FOR PREDICTING AND DIAGNOSING ATRIAL FIBRILLATION AND ESTABLISH A PATIENT-SPECIFIC STEM CELL PLATFORM FOR DEVELOPING PRECISION MEDICINE BASED TREATMENTS.
1501 N CAMPBELL AVE - TUCSON - AZ 85724 • 2021
$175K
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