The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research on Type 1 Diabetic (T1D) nephropathy. This NOFO requests applications for Recruitment Sites (RS) to enroll adult and/or pediatric patients with T1D with, or at high risk of, diabetic nephropathy into a longitudinal cohort study and perform protocol-based research kidney biopsies. These T1D RS will leverage and expand the existing resources of the Kidney Precision Medicine Project (KPMP). T1D RS will collaborate directly with the KPMP to obtain and evaluate kidney biopsies from participants, create a Kidney Tissue Atlas, define disease subgroups, and identify critical cells, interstitial components, pathways, and targets for novel therapies, focused on T1D nephropathy. Information regarding KPMP, including study protocols can be found at About (kpmp.org). Processing of kidney biopsies tissues obtained from the RS, as well as atlas development, will be managed by the KPMP Consortium. Interested potential applicants are encouraged to contact the NIDDK individuals listed below. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in the fall of 2024 with an expected application due date in late fall 2024. This NOFO will utilize the U01 cooperative agreement award activity code. Details of the planned NOFO are provided below.
