Continuing to Enhance Global Health Security: Sustain Efforts and Strategies to Protect and Improve Public Health Globally

The Centers for Disease Control and Prevention, operating under the U.S. Department of Health and Human Services, has forecasted a funding opportunity titled “Continuing to Enhance Global Health Security: Sustain Efforts and Strategies to Protect and Improve Public Health Globally.” This cooperative agreement builds on a decade of U.S. Government support for Global Health Security initiatives. The opportunity continues investments aimed at strengthening the ability of international health systems and institutions to prevent, detect, and respond to public health threats. These efforts reflect the lessons learned from the COVID-19 pandemic and other global health crises. The primary objective of this opportunity is to protect and improve health worldwide through collaborative partnerships with Ministries of Health and other government institutions. The program is designed to reduce the risks of epidemics by improving systems that prevent avoidable outbreaks, including those caused by natural, accidental, or intentional release of pathogens. It also focuses on improving the global capacity to rapidly detect emerging threats, characterize new biological risks, and ensure timely reporting. Additionally, the program emphasizes building capabilities to respond effectively to health threats of international concern to prevent escalation into global crises. The total estimated program funding for this initiative is $75,000,000. The program anticipates making eight awards, although individual award amounts are not yet specified in terms of ceilings or floors. Funding will be distributed through cooperative agreements, which allows CDC to play a substantial role in project implementation and oversight. Cost-sharing or matching requirements are not imposed on applicants, making the program more accessible for a wide range of eligible organizations. Eligibility for this opportunity is broad and encompasses multiple sectors. Eligible applicants include state, county, city, and township governments, Native American tribal governments and organizations, public and private institutions of higher education, public housing authorities, nonprofits with or without IRS 501(c)(3) status, independent school districts, for-profit organizations including small businesses, and special district governments. The eligibility framework is intentionally inclusive to ensure that organizations across different levels of governance and expertise may contribute to global health security efforts. The estimated application due date is January 2, 2026, with applications required to be electronically submitted by 11:59 p.m. Eastern Time on that date. The forecasted post date is November 3, 2025. Award announcements are anticipated by August 31, 2026, with funded projects expected to begin on September 30, 2026. The forecasted opportunity is expected to close on February 1, 2026, should no further updates be issued. At present, no pre-application steps such as letters of intent or concept papers are outlined. Applicants seeking further details or clarifications may contact Broderick Yoerg at 404-234-0666 or via email at DGHPNOFOs@cdc.gov. Additional updates and supporting documents will likely be made available closer to the official release date of the Notice of Funding Opportunity. Given the program’s forecast status, prospective applicants are encouraged to monitor grants.gov for updates and prepare early engagement strategies to position themselves for submission when the application window opens.