New Generation of Glucose Control Technologies Incorporating AI/ML Tools/Strategies

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH), has announced a forthcoming funding opportunity focused on advancing glucose control technologies that integrate artificial intelligence (AI) and machine learning (ML). The opportunity is detailed under the forecasted grant number NOT-DK-26-307. Although applications are not yet being accepted, the NIH has provided an advance notice to allow researchers and institutions ample time to prepare. The forecast indicates that the formal Notice of Funding Opportunity (NOFO) will be released in September 2025, with applications due by October 1, 2025. The grant initiative seeks to overcome scientific and technological barriers to improving open- and closed-loop diabetes control systems. Funded research may address innovations in sensing physiological signals and analytes, novel hormone delivery mechanisms, the use of AI/ML-driven algorithms, and the development of digital twin models. The overarching aim is to improve glycemic control, reduce patient and caregiver burden, and enhance the quality of life for individuals living with Type 1 Diabetes (T1D). Applications will utilize the NIH R01 Research Project Grant mechanism. Collaboration across disciplines is encouraged, and applicants are expected to demonstrate expertise in relevant scientific and technological areas. This includes but is not limited to behavioral science, endocrinology, AI, data science, device design, and clinical or preclinical testing. The NIH especially encourages projects that are multidisciplinary and combine technical innovation with clinical relevance. International applicants and organizations are eligible, and diverse institutional types such as universities, small businesses, public housing authorities, and tribal entities are all considered eligible applicants. The opportunity anticipates approximately six awards, with an estimated total program funding of $3,000,000. Specific award ceiling and floor amounts have not yet been disclosed. No cost sharing or matching is required. The project start date is projected for July 1, 2026, with awards issued by June 1, 2026. While this is currently a forecasted notice, it is intended to promote early planning and collaboration among potential applicants. The notice confirms that the funding opportunity is nationwide in scope and includes U.S. territories and certain foreign institutions. The point of contact for this funding opportunity is Guillermo Arreaza-Rubín of the NIDDK, reachable at 301-594-4724 or via email at ga96b@nih.gov. Additional eligibility details include federally recognized and non-recognized tribal organizations, faith-based entities, and U.S. government agencies. The forecast serves as a preparatory step, signaling NIH’s commitment to advancing technological interventions in T1D care. Applicants are advised to monitor Grants.gov for the formal NOFO and begin forming teams and concepts in anticipation of the September release.