Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)

The Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required) funding opportunity, offered by the National Institute of Mental Health (NIMH), supports advanced-stage research to develop and test psychosocial interventions targeting mental disorders. This program is part of NIMH’s clinical trials pipeline and emphasizes the experimental therapeutics framework, focusing on interventions that address underlying mechanisms of mental health disorders. The program provides funding for up to three years to replicate findings from prior research and establish a link between target engagement and changes in clinical outcomes. Projects should aim to validate intervention effectiveness while furthering understanding of how psychosocial treatments impact specific cognitive, behavioral, or neurobiological targets. Eligible applicants include a diverse range of organizations such as state and local governments, tribal entities, public and private institutions of higher education, nonprofits, for-profit organizations, small businesses, and community-based organizations. Minority-serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions (HSIs), and Tribally Controlled Colleges and Universities (TCCUs), are encouraged to apply. International applicants and organizations may also participate under specific conditions. Applications are accepted through October 15, 2027, without a specified funding ceiling or floor. Proposed projects must demonstrate a clear trajectory for advancing the psychosocial intervention field, with a focus on improving prevention and treatment outcomes for individuals with mental health challenges. For detailed submission requirements and further information, applicants can review the full NOFO or contact NIH Grants Information at grantsinfo@nih.gov. This funding opportunity provides a critical platform for advancing psychosocial treatments and translating cutting-edge research into impactful therapeutic and preventive interventions.