GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)

The National Human Genome Research Institute, part of the U.S. Department of Health and Human Services, has released a forecast for a new funding opportunity under the Genomics Research to Elucidate the Genetics of Rare Disease program. The program, referred to as GREGoR: Innovation or GREGoRi, is designed to advance rare disease research by promoting innovation in the tools, molecular technologies, and analytical approaches used to identify causal genes and genetic variants linked to rare conditions. The funding mechanism for this initiative will be a U01 cooperative agreement, and clinical trials will not be allowed under this program. The GREGoRi initiative will establish a Data Coordination and Outreach Center, which will function as the central coordination hub for the GREGoRi research network. This center will be responsible for managing and making available the data, metadata, computational tools, and research protocols developed by participating GREGoRi projects. The outreach component of the center will ensure that resources are accessible to the broader research community, fostering collaboration and knowledge sharing across institutions. The forecast outlines that one award is expected under this funding opportunity, with a total estimated program funding of $2,000,000. While the specific award ceiling and floor amounts are not identified in the forecast, the program anticipates issuing one cooperative agreement to support this effort. Matching or cost-sharing is not required. The anticipated award date is July 6, 2026, with funded projects expected to begin on the same date. Applicants eligible to apply for this funding include state governments, county governments, city and township governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status, public housing authorities, Native American tribal governments (both federally recognized and other tribal organizations), for-profit organizations other than small businesses, and small businesses. The program has wide eligibility, ensuring participation from a range of academic, nonprofit, governmental, and industry partners to support its data coordination and outreach goals. The application timeline anticipates that the notice of funding opportunity will be formally posted on September 5, 2025, with full applications due by November 4, 2025. No pre-application deadlines such as letters of intent or concept papers are specified in the forecast notice. Applications are expected to undergo review, with award decisions to be finalized by July 2026. As a recurring NIH program, applicants can anticipate future cycles of GREGoRi funding opportunities. The forecasted opportunity is intended to allow potential applicants sufficient time to form collaborations and prepare competitive proposals in anticipation of the official release. The primary point of contact for the GREGoRi Data Coordination and Outreach Center opportunity is Lisa H. Chadwick at the National Human Genome Research Institute. She can be reached by phone at 301-435-7275 or by email at lisa.chadwick@nih.gov for additional program details or inquiries regarding eligibility and application preparation. This forecast represents the early engagement stage of the funding cycle, with the intent of enabling potential applicants to align resources and partnerships ahead of the full funding announcement.