Research Grants in Clinical Informatics (R01 Clinical Trial Optional)

The Research Grants in Clinical Informatics (R01 Clinical Trial Optional), forecasted under the opportunity number FOR-LM-25-002, is a forthcoming funding initiative administered by the National Institutes of Health (NIH) through the National Library of Medicine (NLM). The NIH, a key agency under the U.S. Department of Health and Human Services, provides critical funding support for biomedical and public health research. The NLM, as the world's largest biomedical library, aims to promote the advancement of biomedical informatics and data science. This grant program intends to catalyze innovative research in the field of clinical informatics. It is designed to support the development and refinement of informatics tools and methodologies that empower clinicians, patients, and the public to better interpret, manage, and utilize health information. Central to this initiative is the promotion of data-driven discoveries, the facilitation of evidence-based clinical decision-making, and the enhancement of personalized and precision health care delivery. Applicants are expected to focus on the design, implementation, and evaluation of domain-independent, scalable, and reproducible methods that handle heterogeneous health-related digital data. This includes, but is not limited to, electronic health records (EHRs), imaging data, clinical notes, and patient-generated data. The overarching goal is to convert raw health data into actionable knowledge that can improve clinical workflows and patient outcomes across diverse settings. The funding opportunity encourages projects that will result in transformative, sustainable, and widely applicable outputs. Interdisciplinary collaboration is a priority, with a strong emphasis on the integration of clinical informatics, data science, machine learning, and human-centered computing. The initiative targets research with the potential to significantly impact healthcare delivery by developing generalizable applications suited for various populations and clinical environments. Although applications are not being accepted at the time of this forecast, the estimated open date is October 6, 2025, with an application due date of February 4, 2026. Award notifications are anticipated by December 4, 2026, with projects slated to start on the same date. The estimated total program funding is $2,500,000, with up to 10 awards expected. No cost sharing or matching is required. This funding opportunity utilizes the R01 activity code and is part of Assistance Listing 93.879 – Medical Library Assistance. Eligible applicants for this grant include small businesses, for-profit organizations (other than small businesses), nonprofits with 501(c)(3) status (excluding institutions of higher education), public and private institutions of higher education, state and county governments, independent school districts, federally recognized and other tribal organizations, and public housing authorities. The grant is open to applicants nationwide. Potential applicants are advised to begin preparing collaborative, responsive projects in anticipation of the official Notice of Funding Opportunity (NOFO). For more information, contact Goutham Reddy, MD, MS, at the National Library of Medicine, via phone at 301-827-6728 or email at goutham.reddy@nih.gov.