Mechanistic Investigations into ADRD Multiple Etiology Dementias (R01 - Clinical Trial Not Allowed)

The "Mechanistic Investigations into ADRD Multiple Etiology Dementias" grant aims to fund research into how interactions between multiple brain pathologies contribute to the worsening of neurodegenerative diseases, with a focus on understanding the cellular and molecular mechanisms involved.

$500,000

Closed

Nationwide

Grant Description

This NOFO would support investigations with a minimum of two relevant co-pathologies (e.g., tau, alpha-synuclein, TDP-43, TMEM106B, vascular), with optional risk factors and co-morbidities, to identify cellular and molecular mechanisms of how/why multi-proteinopathy interactions drive worsening neurodegenerative processes and phenotypic outcomes. Studies should examine co-pathology cellular and molecular interactions across brain regions and time in proximate cell population, across various intracellular dynamics and localization, and upstream and downstream from aggregated protein states to determine what events lead to worse phenotypic outcomes.

Funding Details

Award Range

Not specified - $500,000

Total Program Funding

Not specified

Number of Awards

Not specified

Matching Requirement

Eligibility

Eligible Applicants

State governments

County governments

City or township governments

Special district governments

Independent school districts

Additional Requirements

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Geographic Eligibility

All

Key Dates

Application Opens

February 6, 2024

Application Closes

October 4, 2024

Contact Information

Grantor

NIH Grants Information

grantsinfo@nih.gov

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