The National Institutes of Health (NIH), under the U.S. Department of Health and Human Services, has issued a forecasted funding opportunity titled "Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials." This grant is managed through the National Institute on Drug Abuse (NIDA), specifically its Division of Epidemiology Services and Prevention Research (DESPR). The primary intent of this opportunity is to lay the groundwork for future efficacy, effectiveness, and services research trials in the intersecting domains of substance use and HIV prevention.
The scope of the opportunity is broad and responsive to emerging needs in both prevention and service delivery. Eligible pilot projects may focus on designing or refining interventions aimed at preventing substance use initiation, reducing misuse, or preventing progression to substance use disorder. In addition, research related to HIV eradication and integration of HIV services in substance use settings is welcomed. The emphasis is on preparing for future trials through preliminary research, which may include creating or adapting interventions, developing measurement tools, assessing feasibility and acceptability, or strengthening collaborations among stakeholders.
A unique feature of this forecast is its emphasis on stakeholder engagement throughout the research process. Applicants are expected to integrate perspectives from diverse groups such as policy makers, healthcare providers, people with lived/living experience, youth, and families. The requirement for a well-defined theory of change or logic model reinforces the funder’s commitment to structured, evidence-based approaches.
While this is currently a forecasted opportunity, the estimated post date is July 2, 2026, with applications due by October 2, 2026. Awards are expected to be issued by July 1, 2027, and projects would begin on that same date. This lead time offers prospective applicants an opportunity to build robust, collaborative proposals that address key information gaps or explore novel approaches in the substance use and HIV research space.
The funding instrument type is a grant, and the activity falls under the health category, specifically tied to the Assistance Listing 93.279—Drug Use and Addiction Research Programs. There is no cost-sharing or matching requirement. The number of awards and funding levels are not yet specified in the forecast. Applications from a wide range of organizations are encouraged, including local governments, higher education institutions, tribal entities, for-profit and nonprofit organizations, and both domestic and non-U.S. institutions.
Contact for this opportunity is directed to the NIDA DESPR Program Staff via email. While no PDF documentation is linked at this stage, more detailed guidance is expected closer to the posting date. This forecast allows eligible applicants to begin preparations early and align their pilot proposals with the strategic priorities of NIH and NIDA in combating substance use and HIV.
