Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), is announcing a forecasted funding opportunity titled "Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)." The aim of this initiative is to develop and utilize predictive models and integrative analyses to understand how genomic variation affects genome function. This initiative supports the broader mission of the NHGRI to advance human health through genome research. Through this program, NHGRI intends to fund centers that will become part of the Impact of Genomic Variation on Function (IGVF) Consortium. The funded centers will contribute to a collaborative research network by ensuring that all developed resources are accessible to a broad user base. These centers will also provide analytical support, contribute to shared strategies across the consortium, and guide the experimental design for the IGVF project. All awarded projects will use the UM1 cooperative agreement activity code, which supports large-scale, multi-component research efforts. The total funding anticipated for this program is $5 million, with an estimated five awards to be issued. While specific award ceilings and floors have not been disclosed, the forecast outlines an estimated post date of September 19, 2025, and an estimated application due date of November 19, 2025. Awards are expected to be announced by July 1, 2026, with projects starting the same day. Eligible applicants include a wide range of entities such as state and county governments, Native American tribal governments and organizations, public housing authorities, independent school districts, nonprofits with 501(c)(3) status, institutions of higher education, and for-profit organizations including small businesses. Foreign organizations, as well as non-domestic components of U.S. organizations and foreign components as defined in NIH policy, are also eligible to apply. There is no cost-sharing or matching requirement associated with this funding opportunity. The announcement does not permit clinical trials. This is a discretionary funding category under the “Health” funding activity and aligns with the Assistance Listing number 93.172 for Human Genome Research. For further information or inquiries regarding this funding forecast, interested parties are encouraged to contact Dr. Daniel Gilchrist at the National Human Genome Research Institute. He can be reached by phone at 301-412-2926 or via email at daniel.gilchrist@nih.gov.