NIDA Program Project Grant Applications (P01 Clinical Trial Optional)

The National Institutes of Health, through its National Institute on Drug Abuse, is offering the NIDA Program Project Grant Applications (P01 Clinical Trial Optional) funding opportunity. This program supports collaborative research projects conducted by multidisciplinary teams aimed at addressing significant challenges related to substance use disorders and their associated health consequences. The program is designed to encourage broad-based investigative efforts that align with the agency’s mission and evolving priorities, ensuring the funded projects contribute meaningfully to the field of drug abuse research. The primary objectives of the program are to foster comprehensive research in areas such as neuroscience, genetics, behavior, prevention, treatment, epidemiology, etiology, medications development, health services, and the study of HIV/AIDS and other co-occurring infections like hepatitis C, tuberculosis, and sexually transmitted infections. Applications should present at least three inter-related research projects that are independently meritorious yet complementary, demonstrating a clear and essential relationship to a unified program goal. Each program must also include an administrative core to facilitate synergy and resource sharing, and may include additional cores to support multiple research projects. Eligible applicants include higher education institutions, nonprofits, for-profit organizations, local and state governments, tribal governments, and certain federal agencies. Foreign institutions may not apply, but foreign components within U.S. organizations are permitted. Applicants must complete registrations in the System for Award Management, eRA Commons, and Grants.gov before submission. Each application should clearly define its research strategy, demonstrating synergy among the projects and cores, and should comply with NIH policies on data management, data sharing, and the inclusion of diverse study populations. Applications are submitted through NIH’s ASSIST system or an institutional system-to-system solution. Applicants must adhere to the Multi-Project (M) Instructions in the SF424 (R&R) Application Guide and comply with all relevant NIH policies. The application package must include an Overall component, an Administrative Core, optional additional Cores, and at least three individual research projects. Each project must be well-integrated with the overall program theme and contribute to the program’s scientific goals. The application process also includes compliance with NIH’s Data Management and Sharing Plan, as well as the proper handling of human and vertebrate animal subjects where applicable. The funding opportunity was posted on January 10, 2023, with the earliest application submission date of April 23, 2023. Applications are due by 5:00 PM local time of the applicant organization on NIH standard due dates, with the current cycle’s closing date being September 25, 2025. The opportunity remains active and is accepting applications. Award budgets are not limited but should reflect the actual needs of the proposed project. The maximum project period is five years, with funds contingent upon NIH appropriations and merit of submissions. Matching is not required, and the number of awards is based on available funding and application quality. Applicants can contact several designated NIH officials for assistance: Tamara Haegerich, Ph.D. (Tamara.Haegerich@mail.nih.gov), Evan S. Herrmann, Ph.D. (Evan.Herrmann@nih.gov), Jonathan D. Pollock, Ph.D. (jonathan.pollack@mail.nih.gov), and Roger Little, Ph.D. (alittle@mail.nih.gov). For application submission and system issues, the eRA Service Desk and Grants.gov Customer Support are available. Following peer review, successful applicants will receive a Notice of Award. Recipients must adhere to NIH award policies and reporting requirements, including annual progress reports and compliance with civil rights laws.