Metastasis Research Network (U54 Clinical Trial Not Allowed)

The National Cancer Institute (NCI), part of the U.S. Department of Health and Human Services, is soliciting applications for the Metastasis Research Network under the funding opportunity RFA-CA-25-031. This Notice of Funding Opportunity (NOFO) aims to support research efforts that advance a systems-level understanding of cancer metastasis. Through cooperative agreements under the U54 Specialized Centers mechanism, the program will support interdisciplinary research centers, each of which will contribute to a broader network called MetNet. These centers will explore the non-linear and emergent biological processes that underlie metastasis and seek to integrate knowledge across various biological systems and cancer types. Each applicant center must define a central scientific theme and conduct two to three multidisciplinary projects that contribute to this overarching goal. Key areas of focus include the dynamic interplay between mechanisms such as early dissemination, microenvironment interactions, dormancy, and therapeutic responses. The initiative welcomes research on all cancer types, including rare and pediatric metastatic cancers. This networked approach is expected to unify efforts toward a comprehensive framework for understanding metastasis as a whole-body problem rather than a localized or organ-specific phenomenon. The cooperative agreement model reflects the collaborative intent of the initiative, emphasizing coordination and shared learning across funded centers. Although clinical trials are not allowed under this funding opportunity, preclinical and basic mechanistic studies are central to the program’s design. The total anticipated funding for this NOFO is $6.8 million, with an expected four awards, each potentially receiving up to $1.7 million. Cost sharing is not required. Eligible applicants include a wide range of U.S.-based and international institutions such as non-profit and for-profit organizations, public and private higher education institutions, tribal organizations, local and state governments, and other federal entities. Submissions are due by May 15, 2026, with an estimated project start date of March 1, 2027. The expected release date of the final NOFO is February 24, 2026. Applications must be submitted through Grants.gov, adhering to all NIH and NCI submission standards. While specific application components and evaluation criteria are not detailed in the forecast, it is anticipated that applicants will need to outline their scientific rationale, project design, multidisciplinary approach, and integration within the larger MetNet framework. The primary contact for questions is Joanna M. Watson, reachable by phone at 240-276-6206. Awards will be announced in early 2027, and although the recurrence of the opportunity is not explicitly stated, the structure and nature of this program suggest potential for future iterations depending on funding availability and program success.