NIA Renewal and Competing Revision Cooperative Agreements in Aging Research (U01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) allows for renewal and competing revision applications, and their resubmissions, for awarded U01 research project cooperative agreements focused on aging research.Section I. Funding Opportunity Description This Funding Opportunity Announcement (FOA) allows for renewal and competing revision applications, including resubmissions of renewal and revision applications, for U01 research project cooperative agreements awarded by the National Institute on Aging (NIA). The proposed research must both be related to the focus of the currently funded research and relevant to the mission of NIA. Areas of research that fall within NIA’s mission include: genetic, biological, neuroscientific, preclinical, clinical, behavioral, social, psychological, and economic research related to the aging process, diseases and conditions associated with aging, and other special problems and needs of older Americans. NIA places a major emphasis on, and has substantial resources for, research on Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD). Parent awards must be active at the time of submission. A revision application may be submitted only after the parent U01 has been funded. Revision applications may not request support beyond the end date of the parent award. Resubmissions of Type 1 applications that did not receive funding are not allowed and will be considered non-responsive to this FOA. For applications proposing research involving human subjects: NIA supports a central resource to NIA staff and extramural investigators to facilitate/support the conduct and management of clinical research. This resource, the Clinical Research Operations Management System (CROMS), is a comprehensive data management system to support the business functions, management, and oversight responsibilities of NIA grants that support the conduct of clinical research with human subjects. It is the expectation by NIA that all successful applicants will interface, integrate, or adapt their information system(s) and processes to interact with existing and future components of the CROMS as necessary, including the use of a CROMS data templates as specified.