Limited Competition: Mutant Mouse Resource and Research Centers (U42 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) invites applications for the continued support and advancement of the Mutant Mouse Resource and Research Centers (MMRRC). The MMRRC consortium is expected to facilitate research by identifying, acquiring, evaluating, characterizing, cryopreserving, and distributing mutant mouse strains to qualified biomedical investigators. A regional network of four MMRRCs and an Informatics, Coordination and Service Center (ICSC) collectively serve the needs of the biomedical research community for transgenic, knockout and other genetically-engineered mutant mice and related biomaterials. MMRRC strains are held to the highest standards to optimize reproducibility of studies and assure scientific rigor and transparency; all submitted strains are thoroughly reviewed and documented and include additional quality control measures. The Program Director/Principal Investigator (PD/PI) of each MMRRC in addition to the major resource activities is required to develop a small high risk, high return, research pilot project that complements the goals and needs of the MMRRC consortium. ORIP intends to fund up to four awards, but the overall number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications Award Budget Requested Direct Costs must reflect actual needs of the project. For Renewal (a.k.a. Type 2) applications, no more than a 5 percent (direct cost) increase from the last non-competing year will be accepted. ORIP intends to fund up to four awards, but the overall number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications