Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed)

The Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed) is a forecasted grant opportunity from the National Institutes of Health (NIH), under the Department of Health and Human Services. This grant program is managed through the NIH Office of Research Infrastructure Programs (ORIP). ORIP is responsible for supporting the development and modernization of research infrastructure to advance biomedical research throughout the United States. The NIH operates within a rigorous scientific review structure and maintains long-term oversight of funded construction projects. This opportunity aims to fund the construction or modernization of shared-use research facilities or research-resource facilities. These facilities must serve a broad scientific community and support interdisciplinary collaborative research. The objective is to create or improve research environments that enable innovative biomedical investigations and address emerging health challenges. NIH expects these facilities to support cutting-edge research and help build the future biomedical workforce. Additionally, they should enhance national research capabilities and sustain long-term access to essential research resources. This grant opportunity supports two specific congressionally funded programs: the Biomedical Research Facilities (BRF) program and the HIV/AIDS Research Facilities (HRF) program. The BRF program provides funding for the construction or modernization of general biomedical research facilities, such as core labs, biorepositories, and biosafety-level laboratories. These facilities are intended to be shared spaces that support multi-disciplinary teams and facilitate the use of advanced technologies like high-resolution imaging and nonanimal or human-based research platforms. The HRF program targets the construction or modernization of facilities supporting HIV/AIDS research. Funded facilities must align with NIH’s Office of AIDS Research (OAR) priorities. These include research into the long-term health impacts of HIV, development of novel animal models with high translational accuracy, and vaccine manufacturing spaces designed to address latent viral reservoirs and highly mutable viruses. HRF facilities must significantly contribute to the goals of the HIV/AIDS research agenda and have long-term utility. Eligibility is limited to public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations with 501(c)(3) status other than institutions of higher education. All applicants must demonstrate that the proposed facility will serve a wide research community—whether locally within the institution, regionally among multiple institutions, or nationally. Preference is given to institutions from diverse geographic regions and those categorized as Institutions of Emerging Excellence in biomedical research. This forecasted funding opportunity is expected to be posted on July 28, 2025, with applications due by January 25, 2026. Awards are projected to be made by August 31, 2026, with funded projects starting October 1, 2026. NIH anticipates distributing up to 12 awards under this opportunity, with total program funding estimated at $88 million. While the award floor and ceiling are not specified, matching is not required. For further information, prospective applicants may contact Dr. Xiang-Ning Li at the Office of Research Infrastructure Programs by phone at 301-435-1744 or email at xiang-ning.li@nih.gov.