The National Institutes of Health (NIH), through the National Cancer Institute (NCI), has issued a forecasted Notice of Funding Opportunity (NOFO) for Cancer Center Support Grants (CCSGs), intended to support NCI-Designated Cancer Centers under opportunity number NOT-CA-25-106. These P30 grants are discretionary and classified under the category of Health funding. The NOFO is expected to be officially posted on October 1, 2025, with an estimated application due date of January 25, 2026. Awards are projected to be announced by December 1, 2026, with the funded projects beginning on the same date.
This funding opportunity is specifically structured to support three types of NCI-Designated Cancer Centers. Comprehensive Cancer Centers must demonstrate a significant breadth of research in three major domains: basic laboratory research, clinical research, and prevention, control, and population-based research. Clinical Cancer Centers may focus on one or more of these domains, while Basic Cancer Centers concentrate solely on basic laboratory research. The overarching objective is to leverage institutional cancer research strengths and integrate them into a unified, transdisciplinary research enterprise that transcends institutional boundaries.
Centers funded through this program are anticipated to be hubs of discovery for understanding the nature of cancer and developing better prevention, diagnostic, and therapeutic strategies. They are also expected to contribute to shared research resources, coordinate with other NCI-funded programs, and effectively disseminate their research findings to the broader community for maximum impact.
Applicants eligible to apply include a wide range of entities such as state and county governments, for-profit organizations (including small businesses), nonprofit organizations with 501(c)(3) status, independent school districts, public and private higher education institutions, public housing authorities, and Native American tribal organizations and governments. The funding does not require cost-sharing or matching funds, and while award ceilings and floors have not yet been established, the NOFO will include this information upon publication.
Submission requirements will become available once the full announcement is released. However, interested parties are encouraged to monitor the grants.gov listing and direct any inquiries to the Office of Cancer Centers at NCI via phone at 240-276-5600 or email at ncicenters-r@mail.nih.gov. This opportunity, which is not offered on a rolling basis, is expected to recur, although specific future cycle dates are not yet confirmed.
