Laboratory Twinning: Genome Sequence Analysis as a Tool Investigating an Alleged Biological Weapons Attack

The U.S. Department of State’s Bureau of International Security and Nonproliferation, Office of the Nonproliferation and Disarmament Fund (ISN/NDF), has announced a Notice of Funding Opportunity (NOFO) titled "Laboratory Twinning: Genome Sequence Analysis as a Tool Investigating an Alleged Biological Weapons Attack" under funding opportunity number DFOP0017103. The program seeks to build the forensic genome sequence analysis capabilities of at least two laboratories in Latin America to support investigations of alleged biological weapons attacks. This initiative emphasizes developing bioinformatic, epidemiological, and microbiology expertise to identify anomalies in sequencing results that may suggest deliberate biological modifications. The program aims to address the current concentration of genome sequence analysis capabilities in the Global North by expanding technical expertise and infrastructure in the Global South. The selected laboratories will receive training and participate in technical exchange visits, practical exercises, and a final data analysis scenario designed to simulate real-world investigative pressures. Proposals must demonstrate a plan to assess the capabilities of the partner laboratories, design and execute comprehensive training programs, and ensure long-term sustainability of the technical skills developed during the project. The expected outcomes of this project include advanced technical proficiency in genome sequencing, a thorough understanding of cybersecurity and data chain of custody requirements, and the ability to integrate field sample data with broader epidemiological information. The project also aims to equip laboratories with the analytical skills necessary to detect genome modification techniques and anomalies in pathogen sequences. Performance indicators for the project include adherence to timelines, cost performance, quality of deliverables, compliance with grant terms, and efforts to ensure gender representation and accessibility. Eligible applicants include domestic and foreign not-for-profit organizations, public and private institutions of higher education, foreign public entities, public international organizations, and U.S. federal government entities. Cost-sharing or matching is not required under this funding opportunity. Proposals must clearly outline their approach to achieving the program's objectives, demonstrate organizational capacity for genome sequence analysis, and include a sustainability plan to ensure long-term capability retention after project completion. Applications must be submitted by 11:59 PM Eastern Time on January 31, 2025, via the MyGrants platform. Late or incomplete submissions will not be considered. Proposals will be reviewed based on their alignment with program objectives, organizational capability, cost realism, and past performance on similar projects. The final award decision will be based on the merits of the proposal, alignment with program goals, and availability of funds.