Kidney Precision Medicine Project Central Hub

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a part of the National Institutes of Health (NIH), is preparing to issue a Notice of Funding Opportunity (NOFO) for the continuation of the Kidney Precision Medicine Project (KPMP) Central Hub. This grant opportunity is intended to support the advancement of precision medicine for kidney diseases by enabling the safe and ethical collection and molecular analysis of human kidney biopsy tissue. Since its inception in fiscal year 2017, the KPMP has aimed to discover new molecular pathways involved in the development of chronic kidney diseases (CKD) and acute kidney injuries (AKI). The program expanded in 2022 to broaden participant recruitment and enhance tissue interrogation, reinforcing its commitment to patient-centered research. The anticipated funding will extend the KPMP for another five years, following recommendations from an external evaluation committee in February 2025. The grant will utilize NIH U01 and U24 cooperative agreement mechanisms. The KPMP Central Hub (U24) will focus on clinical and data coordination, integration, analysis, and sharing, serving as the core for programmatic collaboration and data stewardship. Additionally, up to fourteen U01 awards will be distributed to recruitment sites for new participant enrollment, kidney biopsy collection, and longitudinal clinical observation, as well as to tissue interrogation sites specializing in advanced molecular analyses. All sites are expected to collaborate in scientific discovery and contribute to the achievement of the project's overarching scientific objectives. Funding for this opportunity is projected to total $5,000,000. One U24 award will be made for the Central Hub, and up to fourteen U01 awards are anticipated for recruitment and tissue interrogation functions. All components of the program will coordinate closely to ensure rigorous, high-quality research and data sharing across the KPMP network. There are no matching or cost-sharing requirements for this funding opportunity. Eligibility for this grant is broad, encompassing state governments, county governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status, for-profit organizations other than small businesses, Native American tribal organizations and governments, public housing authorities, eligible agencies of the federal government, U.S. territories and possessions, faith-based and community-based organizations, regional organizations, and non-domestic (foreign) entities. The estimated timeline for this opportunity includes a forecasted posting date of July 5, 2026, with an anticipated application due date of October 5, 2026. The expected award date is June 1, 2027, and funded projects are projected to begin on July 1, 2027. The fiscal year for this funding is 2027. This opportunity is currently in the forecasted stage, so applications are not yet being accepted. Applicants and interested organizations are encouraged to monitor the Grants.gov listing for official release and updates to the NOFO. For further information, prospective applicants may contact Dr. Debbie S. Gipson at the National Institute of Diabetes and Digestive and Kidney Diseases, by phone at 301-480-2268 or by email at Debbie.Gipson@nih.gov.