Forecast for NIH Blueprint and BRAIN Initiative ACTION Potential Program (F99/K00 Clinical Trial Not Allowed)

The National Institute of Neurological Disorders and Stroke (NINDS), acting on behalf of the NIH Blueprint for Neuroscience Research and the BRAIN Initiative, plans to issue a Notice of Funding Opportunity (NOFO) for the ACTION Potential Program under the F99/K00 grant mechanism. This forecasted funding opportunity is titled “Forecast for NIH Blueprint and BRAIN Initiative ACTION Potential Program (F99/K00 Clinical Trial Not Allowed)” and is intended to support neuroscience graduate students in their transition from doctoral studies to postdoctoral research positions. The ACTION Potential Program is structured to promote academic career development and long-term research careers in neuroscience aligned with the missions of the NIH Blueprint and the BRAIN Initiative. The initiative emphasizes a defined career development path by offering a two-phase award. The first phase supports the completion of the doctoral dissertation, while the second supports the transition to and engagement in a postdoctoral research position. This program is designed for individuals demonstrating strong potential and commitment to becoming independent investigators in neuroscience. While this funding opportunity is not yet open for applications, its forecast allows potential applicants time to establish collaborations and prepare responsive proposals that align with the program's objectives. The funding activity is classified under the health category and falls within the assistance listing number 93.853, which covers extramural research programs in neurosciences and neurological disorders. While the specific award amounts and total program funding are not yet disclosed, the grant is expected to be highly competitive and will not require cost-sharing or matching funds from applicants. Eligibility for this opportunity is broad and includes a diverse range of applicant types. Eligible entities include Native American tribal organizations and governments, public housing authorities, county and state governments, for-profit organizations other than small businesses, small businesses, independent school districts, public and private institutions of higher education, and nonprofits with 501(c)(3) status excluding higher education institutions. This inclusivity ensures wide participation from various institutions committed to advancing neuroscience research. The estimated timeline for the opportunity begins with an anticipated posting date of November 3, 2025. Applications are expected to be due by March 20, 2026, with award announcements and project start dates scheduled for December 1, 2026. The forecast was last updated on May 27, 2025, and pertains to the fiscal year 2027. This forecast does not represent an active call for proposals but serves as an advance notice to encourage early planning. Applicants and interested parties can seek further information or clarification by contacting Dr. Lauren Ullrich at the National Institute of Neurological Disorders and Stroke. She can be reached by phone at 301-451-7964 or via email at nindsotwd@ninds.nih.gov. This advance notice is crucial for encouraging strategic preparation and alignment with the grant’s career development goals.