Single Source: Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Coordinating Center (U01 Clinical Trial Required)

The National Human Genome Research Institute (NHGRI), under the U.S. Department of Health and Human Services and the National Institutes of Health (NIH), is forecasting a Notice of Funding Opportunity (NOFO) titled “Outcomes of Electronic Medical Records and Genomics (eMERGE) Genomic Risk Assessment and Management Network - Coordinating Center (U01 Clinical Trial Required).” This funding opportunity aims to support a coordinating center that will manage and analyze long-term outcome data for participants involved in genomically informed risk assessment (GIRA) and management within the eMERGE network. The NOFO will be published under a single-source model and will use the U01 cooperative agreement funding mechanism, which requires active NIH involvement. This initiative will continue the work from the eMERGE Genomic Risk Assessment and Management Study by extending follow-up of 25,000 participants from a minimum of one year to at least four years. The purpose is to evaluate adherence to GIRA-based preventive recommendations and their outcomes over a longer timeframe. It will also explore demographic and social determinants that may influence adherence to these recommendations. This continued data collection and analysis are integral to the long-term understanding of genomic medicine’s impact on public health. Eligibility for this grant is highly restricted. Only the Principal Investigators (PI/PDs) affiliated with the prior award under RFA-HG-19-015 to Vanderbilt University Medical Center are eligible to apply. This makes the opportunity single-source in nature, tailored for the continuation of a previously awarded project. Eligible applicant types technically include public and private higher education institutions and nonprofits with 501(c)(3) status, but functionally only those linked to the specified prior award are allowed to submit. The estimated total program funding is $1,200,000. The grant is expected to result in a single award, with no requirement for matching funds. Important forecasted dates include an estimated post date of September 19, 2025, an application due date of November 19, 2025, and an anticipated award date of July 1, 2026, which also serves as the estimated project start date. This timeline offers a preparatory window for the sole eligible applicant to develop a comprehensive proposal. Application materials and further information will be accessible through the Grants.gov portal once the NOFO is formally posted. Dr. Robb Rowley at the NHGRI serves as the grant contact and can be reached at Robb.Rowley@nih.gov or via phone at 301-827-9126 for additional details or inquiries.