Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)

The National Institutes of Health (NIH), specifically the National Institute on Aging (NIA), is preparing to release a Notice of Funding Opportunity (NOFO) titled "Complex Integrated Multi-Component Projects in Aging Research" under the U19 activity code. This initiative aims to support large-scale, multidisciplinary research initiatives that integrate multiple components into a cohesive, collaborative research program focused on a unified question in aging research. The opportunity is structured to foster collaboration among investigators from either a single institution or multiple institutions working as a consortium. This upcoming funding opportunity emphasizes synergy among diverse research components. Applicants will be expected to demonstrate how the various elements of their proposed project contribute to a unified scientific objective, ensuring that all parts are not just parallel but are functionally integrated. The approach encourages methodological diversity and thematic focus while mandating a high level of coordination across project arms. Each application will be assessed on how effectively it fosters multidisciplinary interaction and generates comprehensive findings around a common aging-related hypothesis. Funding will be distributed through cooperative agreements, signifying substantial involvement by NIH in project activities. Although full budgetary parameters and award totals have not yet been specified, this mechanism is intended for complex, resource-intensive projects and may support multiple awards. The funding falls under CFDA 93.866 – Aging Research. Cost sharing or matching is not required. Eligibility for this program is broad and inclusive, covering most U.S. public and private higher education institutions, state and local governments, Native American tribal entities, nonprofits, and for-profit organizations, including small businesses. This includes both 501(c)(3) and non-501(c)(3) nonprofits, faith-based organizations, public housing authorities, and certain regional and federal agencies. This is currently a forecasted opportunity with an estimated posting date of March 25, 2026. The anticipated application due date is May 25, 2026, and awards are projected to be announced by April 25, 2027, with projects beginning the same day. Although there are no pre-application requirements such as Letters of Intent or Concept Papers at this time, potential applicants are encouraged to begin building the necessary collaborations and infrastructure. While application details and evaluation criteria will be provided once the NOFO is formally released, the NIA encourages early planning. Communication regarding scientific aspects of the program can be directed to the NIA Scientific Contact via email. As this is a recurring initiative in aging research, applicants should also anticipate future opportunities following a similar timeline.