Building capacity for sustainable and integrated HIV/AIDS prevention, care, and treatment programs in the Republic of Mozambique under the President's Emergency Plan for AIDS Relief (PEPFAR)

The Centers for Disease Control and Prevention (CDC), operating under the U.S. Department of Health and Human Services (HHS), has forecasted a cooperative agreement funding opportunity titled “Building capacity for sustainable and integrated HIV/AIDS prevention, care, and treatment programs in the Republic of Mozambique under the President's Emergency Plan for AIDS Relief (PEPFAR).” This opportunity is designed to strengthen public health systems and improve the sustainability of HIV and tuberculosis (TB) programs through technical assistance and institutional capacity building in Mozambique. It aligns with the PEPFAR initiative, a U.S. government program dedicated to combating the global HIV/AIDS epidemic, particularly in high-burden regions such as sub-Saharan Africa. The program’s main objective is to provide technical assistance to Mozambique’s Provincial Health Directorates and other national and local stakeholders. The selected recipients will support the implementation of prevention, care, and treatment services for HIV and TB at multiple levels of the health system, including national, provincial, district, and sub-district levels. The initiative seeks to enhance local ownership and ensure the long-term sustainability of HIV programs by strengthening systems, training health professionals, and improving data management and service delivery mechanisms. Under this cooperative agreement, the CDC anticipates funding approximately four awards in its first year of implementation. The total estimated funding available for Year 1 is approximately $83 million, subject to the availability of appropriations. The program does not require cost-sharing or matching funds from applicants, enabling a broad range of eligible organizations to apply. Funding will support technical assistance, capacity development, and complementary implementation support activities, ensuring alignment with national HIV/TB strategies and PEPFAR priorities. Eligible applicants include a wide array of public and private entities, such as U.S. and foreign governmental units, educational institutions, nonprofit and for-profit organizations, and tribal governments. Specifically, eligibility encompasses state, county, and city governments, Native American tribal governments and organizations, independent school districts, public and private institutions of higher education, public housing authorities, special district governments, and nonprofit organizations with or without 501(c)(3) status. For-profit organizations, including small businesses, are also eligible. Applicants should demonstrate proven experience in international public health programming, especially in HIV/AIDS service delivery and systems strengthening in resource-limited settings. The forecast indicates an estimated posting date of December 2, 2025, with applications due by February 17, 2026. The anticipated award date is September 30, 2026, with project implementation expected to begin immediately thereafter. All applications must be submitted electronically through Grants.gov by 11:59 PM Eastern Time on the due date. Interested applicants may contact the CDC’s DGHT NOFO team via email at pepfarfoas@cdc.gov for technical and programmatic inquiries. As a forecasted opportunity, this NOFO may be updated or amended prior to the official posting.

Applicants should demonstrate capacity to support national HIV/AIDS systems strengthening and comply with PEPFAR reporting standards.