Investigate Novel Therapeutic Interventions and Testing Strategies for Neurological Disorders Including to Treat, Modify and Prevent the Development of Epilepsy (U24 Clinical Trial Not Allowed)

The National Institute of Neurological Disorders and Stroke, part of the U.S. Department of Health and Human Services, has announced a forecasted funding opportunity for research on therapeutic interventions and testing strategies targeting neurological disorders. The Notice of Funding Opportunity will specifically focus on the development of treatments and approaches to prevent or modify the onset and progression of epilepsy, among other related neurological conditions. This initiative reflects the institute’s ongoing mission to reduce the burden of neurological disease through research and innovation. The opportunity seeks to support investigators exploring diverse intervention modalities and testing methodologies. A major emphasis is placed on strategies designed for the development and validation of human-focused testing approaches. The program encourages researchers with expertise in preclinical therapy testing and model development to apply, recognizing the importance of strong translational pathways from laboratory to clinical application. While clinical trials are not permitted under this award mechanism, applicants are expected to contribute significantly to foundational work that informs clinical research. Funding will be made available through a cooperative agreement mechanism, allowing for substantial involvement of the National Institutes of Health program staff during the conduct of the supported activity. This engagement ensures that the funded projects align with national priorities in neurological research and maximize their potential to accelerate new discoveries. With a total estimated program funding of $6.2 million, awards will range between $3.5 million and $4 million. Only one award is expected to be issued, highlighting the competitive nature and significant scope of this opportunity. Eligibility for this grant is broad and inclusive, spanning a wide range of organizations. Eligible entities include state, county, and city governments; special district governments; independent school districts; public housing authorities; Native American tribal governments and organizations; for-profit and nonprofit organizations, including those with or without 501(c)(3) status; small businesses; public and private institutions of higher education; faith-based and community organizations; regional organizations; and non-domestic (non-U.S.) entities such as foreign institutions. Federal government agencies and U.S. territories are also eligible to apply. This diverse eligibility structure aims to attract a wide spectrum of applicants with the expertise needed to advance the field. The timeline for this opportunity is clearly defined. The funding announcement was forecasted on September 23, 2025, with the official posting anticipated on December 19, 2025. The application deadline is expected on February 20, 2026. Awards will be announced on November 2, 2026, with funded projects scheduled to begin on December 1, 2026. These dates provide a structured timeline for preparation, submission, and review, giving potential applicants ample time to develop strong proposals. The funding will be tied to the fiscal year 2027. For further information, interested applicants can contact the scientific program officer. The designated contact is Brian Klein, PhD, available by phone at (301) 496-0981 or via email at brian.klein@nih.gov. This contact information provides applicants with direct access to program staff for clarification of requirements and guidance on the application process. Applicants are encouraged to engage early with program staff to ensure alignment between their proposed projects and the goals of the funding opportunity.