Notice of Intent to Publish a Funding Opportunity Announcement for Comprehensive Alcohol Research Centers (P60 Clinical trial Optional)

The Comprehensive Alcohol Research Centers (P60 Clinical trial Optional) funding opportunity, announced under opportunity number RFA-AA-25-012, is issued by the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services. This program is part of the Alcohol Research Programs under Assistance Listing 93.273. NIH has a longstanding mission to advance biomedical and behavioral research, and this initiative reflects its continued investment in developing integrated, multidisciplinary, and multi-investigator programs that focus on major research themes concerning alcohol use and its impacts on health. The purpose of this Notice of Funding Opportunity is to support long-term, broad-based research centers that foster collaborative investigations into the biomedical and behavioral aspects of alcohol consumption and its related disorders. By utilizing the P60 grant mechanism, NIH intends to strengthen research infrastructure through the integration of multiple scientific approaches and by supporting a wide array of activities aligned with a central research theme. These centers are expected to combine basic, clinical, and community-based studies to produce comprehensive insights and enhance knowledge translation into public health practice. The scope of the program emphasizes building sustainable, well-supported research hubs that can address alcohol-related health issues across diverse populations. Funding may be used to support investigator-initiated projects, core facilities, and training opportunities for junior researchers, as well as to promote the development of translational and clinical research. The optional clinical trial component provides flexibility, allowing applicants to incorporate intervention studies where appropriate to strengthen the program’s scientific contributions. Eligibility for this opportunity is broad. The list of eligible entities includes nonprofits with and without 501(c)(3) status, public and private institutions of higher education, for-profit organizations, small businesses, independent school districts, state, local, and tribal governments, and housing authorities. In addition, the program explicitly allows participation by Native American tribal governments and organizations, faith-based and community-based groups, regional organizations, and U.S. territories. Federal government agencies are also considered eligible applicants. This inclusive scope underscores NIH’s intent to attract diverse organizations with the capacity to support large-scale, multidisciplinary alcohol research. The forecasted timeline indicates that the estimated post date is November 20, 2025, with an application due date of January 21, 2026. Awards are expected to be issued by September 15, 2026, with funded projects beginning January 15, 2027. The notice does not specify any pre-application deadlines, such as a required letter of intent. Applications will be evaluated through the NIH peer review process, and applicants must prepare detailed proposals demonstrating the integration of research projects around a central alcohol-related theme. For further details or inquiries, applicants may contact the NIH program officer, Philippe Marmillot, at 301-605-5544 or via email at marmillotp@mail.nih.gov. As this is a forecasted opportunity, final application materials and requirements will be published in the official funding announcement once the notice of funding opportunity is formally released. Applicants should monitor the NIH and Grants.gov platforms for updates and final instructions before submission.