BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)

The BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed), offered by the National Institutes of Health (NIH), seeks to accelerate the integration and dissemination of innovative research tools and resources across the neuroscience research community. As part of the larger Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, this funding opportunity aligns with strategic visions laid out in "BRAIN 2025: A Scientific Vision" and "The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures." The initiative is designed to ensure that developed resources are widely accessible, effectively integrated into research workflows, and meet the evolving needs of neuroscience investigators. This Notice of Funding Opportunity (NOFO) specifically supports dissemination activities for already-developed research resources that fulfill critical gaps or inefficiencies in neuroscience research. Eligible activities under this NOFO include but are not limited to distribution of tools and reagents, user training in novel technologies or methodologies, providing shared access to technology platforms and specialized facilities, and minor improvements or adaptations that expand usability or scalability for end users. While dissemination is required, the scope allows for strategic adaptation or refinement of resources to meet broader community needs, emphasizing integration and accessibility. Applications must be submitted through the Grants.gov portal, with the final application deadline set for October 6, 2028. While there are no pre-application requirements such as Letters of Intent or Concept Papers, applicants must comply with all eligibility guidelines and NIH policy restrictions regarding foreign collaborations. Specifically, foreign organizations and non-U.S. components of U.S. organizations are ineligible to apply. Additionally, NIH will not fund projects involving foreign subawards or subcontracts unless they are part of a NOFO specifically designated for international collaboration. However, the inclusion of foreign components such as consultants or procurement of equipment from international vendors remains permissible under defined guidelines. The NOFO anticipates issuing up to 20 awards, with an estimated total program funding of $10,000,000. Award ceilings and floors are unspecified, indicating potential variability based on project scope and merit. As a cooperative agreement, this funding mechanism allows for significant NIH involvement in the execution and monitoring of funded projects, reinforcing the program’s commitment to effective dissemination and integration of resources. No cost-sharing or matching requirement is mandated under this opportunity. Eligibility spans a wide range of applicant types, including nonprofits (with or without 501(c)(3) status), public and private institutions of higher education, independent school districts, state and local governments, tribal governments and organizations, public housing authorities, and certain for-profit entities including small businesses. This inclusivity ensures a broad applicant base capable of advancing the BRAIN Initiative's objectives while adhering to NIH's evolving policies regarding international collaborations. Interested applicants can direct questions or seek clarification via the dedicated program email, [email protected]. Although no PDF version of the NOFO was located within the provided source material, all application materials and instructions are accessible through the official Grants.gov portal. Given the 2028 deadline and the absence of rolling submissions, this NOFO presents a multi-year opportunity for institutions planning to contribute substantially to the dissemination and scaling of impactful neuroscience research tools and infrastructure.

Include quantifiable dissemination milestones; plan for early dissemination; align with BRAIN 2025 priorities; consult NIH contacts for project alignment.