Strategic Prevention Framework - Partnerships for Success for Communities/Tribes

The Strategic Prevention Framework - Partnerships for Success for Communities/Tribes (SPF-PFS-Communities/Tribes) is a forecasted grant opportunity administered by the Substance Abuse and Mental Health Services Administration (SAMHSA), a division of the U.S. Department of Health and Human Services. This program is funded through Assistance Listing 93.492 and supports regional and national significance projects overseen by the Center for Substance Abuse Prevention. The SPF-PFS initiative is a continuation of SAMHSA’s broader commitment to reducing substance use and misuse across the United States, especially in communities and tribal regions that may experience disproportionate impacts from substance use-related harms. The primary objective of this grant program is to prevent and reduce the initiation and progression of substance use, particularly among youth and other vulnerable populations. It achieves this by bolstering the development and delivery of community-based prevention services. These services are designed to enhance protective factors, reduce risk factors, and promote mental health and resilience within the target populations. Additionally, the program focuses on strengthening the infrastructure and capacity of community and tribal prevention providers to implement evidence-based, evidence-informed, and culturally responsive prevention strategies. Grantees will be expected to use funds to deploy comprehensive prevention activities that may include outreach, education, and strategic planning efforts tailored to community needs. The grant encourages the use of strategies that are supported by research or that are defined by communities and tribes as effective based on their own metrics and lived experience. There are no matching fund requirements for applicants, which broadens the opportunity for organizations with limited budgets to apply. Allowable use of funds will likely be guided by SAMHSA’s existing policies on program implementation, although specific allowable and disallowed costs will be clarified upon official notice of funding availability. Eligible applicants for this funding opportunity include political subdivisions of states, tribal governments and tribal organizations as defined by federal law, and public or private nonprofit entities, including faith-based organizations. Additionally, health facilities or programs that operate through or in collaboration with the Indian Health Service are considered eligible. The eligibility criteria reflect SAMHSA’s intent to ensure that a wide variety of local, culturally competent organizations can access support for substance use prevention efforts. As of the forecast date (March 20, 2026), the estimated date for the official posting of the opportunity is May 1, 2026. Submission deadlines, award announcements, and project start dates have not yet been released. Applicants are encouraged to monitor Grants.gov and SAMHSA’s website for updates regarding application opening and closing dates. While no pre-application requirements have been outlined, prospective applicants should prepare for a typical federal grants submission process through Grants.gov, likely including the standard forms and narratives such as program narratives, budgets, organizational capability, and evidence of eligibility. For questions or further information, potential applicants can contact Carmen Kelly at (202) 924-0334 or via email at [email protected]. While this opportunity is still in the forecast stage, organizations that anticipate applying should begin preparing by reviewing their capacity to implement prevention strategies aligned with the Strategic Prevention Framework, securing relevant partnerships, and identifying needs within their communities or tribes that the program could address. This program represents a significant investment in community-level infrastructure to combat substance use and its associated challenges.