NIDA REI: Racial Equity Visionary Award Program for Research on Substance Use and Racial Equity (DP1 Clinical Trial Optional)

Funding Opportunity Description Purpose The Racial Equity Visionary Award Program embraces transformative science by supporting independent investigators proposing highly innovative research that 1) challenges scientific paradigms that perpetuate inequities, and 2) lays groundwork for large scale efforts to impact substance use-related disparities that affect underserved U.S. racial and/or ethnic minority populations. PIs are expected to self-identify as health equity, health disparities, or social determinants of health researchers and have prior experience conducting collaborative research projects with one or more underserved racial and/or ethnic minority population groups. The application should reflect an exceptionally creative approach to problem solving and a long-term commitment to solution-oriented research with underserved racial and/or ethnic minority communities. Background Evidence suggests that patterns of substance use, consequences of substance use, and access to services to prevent and treat substance use disorders vary significantly across populations. Structural factors, including racism and discriminatory practices, create conditions that lead to population-level health disparities. While various research studies document the disparities, relatively few researchers seek to bring a deep understanding of the social construction of race and its manifestations in the daily lives of U.S. residents to inform system-level changes to policy and practice. The NIH is committed to supporting health equity research to 1) improve minority health and reduce health disparities and 2) remove the barriers to advancing health disparities research (for more information, see the NIH Minority Health and Health Disparities Strategic Plan 2021-2025. In alignment with this NIH-wide effort, NIDA established the Racial Equity Initiative (REI), with goals that include promoting racial equity in NIDA’s research portfolio. Among the actions taken by NIDA, which were informed by internal and external meetings and listening sessions, the Institute has committed to a significant increase in funding for research to address racial and ethnic disparities in outcomes related to drug use and HIV. The REI funding opportunity announcements (FOAs) seek to advance equity by supporting research and research training efforts that are consistent with NIDA’s mission and with best practices for conducting research with racial and ethnic minority populations. Research Objectives The Racial Equity Visionary Award program is designed to support health equity scholars conducting clinical research to better understand and/or intervene on systemic factors that drive disparities for racial and/or ethnic minority populations related to NIDA’s mission. For NIH, the definition of clinical research is broad, and includes epidemiological and behavioral studies, intervention research, outcomes research/health services research in addition to patient-oriented research (see the NIH Grants Policy Statement). Investigators may propose to conduct various types of studies, such as natural experiments, cohort studies, policy research, optimization research, pilot/feasibility intervention trials, modeling studies, qualitative/mixed-methodsresearch studies, orhuman laboratory trials. Pilot or preliminary data may be included in the application, but they are not required for this award. Applications include an essay describing research to advance health equity for one or more underserved racial and/or ethnic minority populations that bear a disproportionate share of the health, social, and legal consequences of substance use (e.g., deaths, injuries, infections, disorders, homelessness, arrests, job loss). For the purposes of this FOA, health equity is defined as all people having the opportunity to reach their full health potential and no one being disadvantaged from achieving this potential because of social position or other socially determined circumstances. Applications should justify the slection of study populations using data that illustrate significant present and/or historical discrimination, mistreatment, isolation, or inequity. Investigators may propose projects addressing equity at the intersection of race/ethnicity and another social or demographic characteristic (e.g., sex, gender, sexuality, socioeconomic status, age, geographic location, education level, disability status, immigrant status, English language proficiency). The Racial Equity Visionary Award, projects must involve collaborations with community members who represent the population affected by inequities, particularly individuals with lived experience. In addition, investigators are encouraged to engage contributors from various stakeholder communitiesbackgrounds as needed such as lay health workers, community leaders, patient advocates, and service providers. PIsApplicants are strongly encouraged to collaborate with individuals from the community throughout the research process.This initiative invites applications for DP1 awards to support exceptionally creative early career investigators who propose high-impact projects that lead to advances in equity across populations affected by substance use-related harms. Investigators who apply may represent various fields of research, but research projects will emphasize persistent or intractable challenges that drive disparities in medical and other consequences related to substance use and SUD across population groups.