GREGoRi Technology Integration Center (U01, Clinical Trials Optional)

The GREGoRi Technology Integration Center funding opportunity, managed by the National Institutes of Health (NIH) through the National Human Genome Research Institute (NHGRI), is a forecasted initiative aimed at enhancing rare disease diagnostics. The grant will support the establishment of the GREGoRi Technology Integration Center (TechIC) under the GREGoRi: Innovation renewal of the GREGoR program. This program seeks to innovate the diagnostic process for rare genetic disorders by leveraging cutting-edge molecular technologies and novel analytical strategies. The TechIC will be responsible for creating and promoting standards and best practices for using emerging molecular methods in rare disease diagnosis. A key deliverable from this center will be the production of a multidimensional dataset, which will serve as a resource for developing and benchmarking new diagnostic tools and strategies. This effort aims to accelerate the identification of causal genes or variants responsible for rare diseases, thereby enabling more timely and accurate diagnoses. This opportunity will be offered through a cooperative agreement using the U01 activity code, and it allows for optional inclusion of clinical trials. The total program funding is projected at $3,000,000 with one award expected. No cost sharing or matching is required from applicants. The Notice of Funding Opportunity (NOFO) is scheduled to be published on September 5, 2025, with applications due by November 4, 2025. The estimated award date is July 6, 2026, with the project start date aligning with the same. Eligible applicants include a broad range of organizations, such as state and county governments, federally recognized and other tribal governments and organizations, public housing authorities, public and private institutions of higher education, independent school districts, nonprofits with 501(c)(3) status, for-profit organizations (excluding small businesses), and small businesses. Applicants should prepare for collaboration-based proposals that align with the GREGoRi initiative’s objectives. The NIH provides ample lead time to allow the development of robust and responsive projects. Specific application questions are not listed in the forecast notice, but proposals will likely need to demonstrate technical capacity, a clear research agenda, and collaborative readiness. For additional information, potential applicants can contact Lisa H. Chadwick at the National Human Genome Research Institute via phone at 301-435-7275 or by email at lisa.chadwick@nih.gov. This forecast aims to give ample notice so applicants can prepare strong submissions once the NOFO is formally released.

Applicants are encouraged to begin building collaborative projects early, as this is a complex, integrative initiative.