Mechanistic links between diet, lipid metabolism, and tumor growth and progression (U01 Clinical Trial Not Allowed)

The NIH funding opportunity (PAR-25-119) invites applications for mechanistic research into the links between diet, lipid metabolism, and cancer growth and progression. This U01 cooperative agreement, which does not permit clinical trials, seeks to support studies that investigate how lipid metabolism mediates tumor dynamics, particularly how dietary factors influence cancer biology through lipid pathways. The program aims to bridge nutrition and molecular metabolism research to advance understanding in this complex area and encourage the development of tools to overcome challenges in lipid biochemistry. Eligible applicants include public and private institutions of higher education, local and state governments, tribal organizations, nonprofits, small businesses, and certain minority-serving institutions like HBCUs. While non-U.S. institutions cannot apply directly, foreign components can be part of U.S.-based projects. Applications are due by October 23, 2025, with an archive date of November 28, 2025. There is no cost-sharing requirement, and specific funding amounts are not disclosed. For more details, prospective applicants can consult the full NIH announcement or contact NIH Grants Information for assistance. This grant is ideal for institutions focused on fundamental cancer research, particularly in the intersection of nutrition, lipid metabolism, and oncology.