Grants for Special district governments - Health

This funding opportunity supports promising predoctoral students from diverse backgrounds to conduct research in translational studies related to Alzheimer's disease and related dementias, fostering skills essential for advancing this critical field.

Notice of Funding Opportunity Description Background Although vaccines are among the most effective approaches to control viral diseases, developing a prophylactic or therapeutic HIV vaccine has proven elusive. There are no licensed vaccines for HIV. Strategies for induction of HIV broadly neutralizing antibodies will likely require repeated exposures over long periods, including immunization with distinct antigens in sequential order. Such immunization strategies will require development of technologies for controlled vaccine release. Recent advances in materials-based science, controlled release technologies, delivery systems, and immunology provide opportunities to enhance the quality, potency and durability of vaccine-induced T cell and antibody responses to HIV-1. Materials-based approaches can be engineered to improve the stability, spatiotemporal release, and presentation of multiple vaccine components; for example, by controlling the time frame and dose of vaccine delivery over days to weeks. Recent studies have shown that a slow-release vaccine is superior to bolus administration at inducing breadth, potency, and durability of antibody responses to HIV antigens by prolonging antigen exposure in the germinal centers, thereby enhancing the maturation of B cells and generating stronger humoral immune responses. Further research is needed to elucidate the mechanisms underlying the immunological improvements observed with slow-release vaccine delivery and to translate such concepts into clinical application. It will be crucial to determine how the duration of exposure to vaccine components impacts immune cell biology, and how to calibrate vaccine release to improve responses while avoiding immune exhaustion and over-activation. Advancing safe, effective, and well-tolerated controlled release vaccines is an unmet need that may enhance vaccine effectiveness and practicality, leading to better adherence to complex regimens, fewer adverse reactions, and cost savings. Finally, iterative behavioral studies during product development to determine vaccine/provider product expectation/preferences are critical to facilitate product uptake and use.

This funding opportunity supports primary care centers in implementing genomic screening for common genetic conditions to improve disease prevention and care, particularly in underrepresented communities.

This funding opportunity provides financial support to designated cancer research centers in the U.S. to enhance their multidisciplinary research efforts in cancer prevention, diagnosis, and treatment.

This funding opportunity supports research initiatives focused on non-communicable diseases related to HIV at institutions in low- and middle-income countries, encouraging innovative projects and collaborations to improve health outcomes for people living with HIV.

This funding opportunity provides financial support to education and health agencies for developing and implementing sustainable school-based strategies to prevent HIV and STDs among middle and high school students in the United States.

This funding opportunity provides financial support for research projects that address the information and practice needs of caregivers and professionals working with children who experience delays in language development, particularly focusing on diverse communities.

This funding opportunity supports U.S.-based researchers and organizations working to improve stem cell-derived islet cells for treating type 1 diabetes through innovative engineering approaches.

This Notice of Funding Opportunity (NOFO) seeks to foster new multi-disciplinary teams to address how HIV Comorbidities and co-infections within the missions of NIDDK and NIAID interact with viral reservoirs, potentially confounding cure strategies aimed at either sustained viral suppression or elimination from the body. These teams will mechanistically interrogate the impact of inflammation, metabolic perturbations, or other pathophysiological processes associated with these comorbidities or co-infections on reservoir dynamics, and/or the interplay of these conditions and co-infections on HIV reservoir biology in ways that are likely to interact with potential cure strategies.

This funding opportunity provides financial support to nonprofit organizations and municipal agencies in New York State to implement community-level strategies that promote healthy eating and physical activity, particularly in underserved areas.

This grant provides funding to organizations for implementing suicide prevention training in correctional and juvenile detention facilities in Illinois, focusing on at-risk youth and older males in underserved communities.

This funding opportunity provides rapid financial support for researchers to study health outcomes related to urgent events like pandemics, natural disasters, or sudden policy changes, allowing them to gather critical data quickly.

This grant provides funding for early stage investigators to pursue innovative and high-risk research projects involving human participants, without the need for preliminary data.

This funding opportunity supports innovative research aimed at understanding and improving treatment for schizophrenia and related disorders in individuals aged 35 and older.

This funding opportunity provides resources to rural health networks to improve access, coordination, and quality of essential health services for underserved populations in rural communities.

The purpose of this funding opportunity announcement is to provide tailored support for early stage investigators (ESIs) to initiate basic or translational research with nonhuman primates (NHPs). These awards will allow ESIs additional funds, time to generate preliminary data, and the opportunity to establish all skills needed to set up and run an NHP laboratory independently. It is expected that these awards will thereby improve an ESIs ability to secure larger research awards (e.g., R01) and will facilitate their transition to independent tenure-track positions.

This funding opportunity supports researchers conducting small clinical trials to develop and test innovative devices for recording and stimulating the human brain, aimed at treating central nervous system disorders.

This funding opportunity provides financial support to organizations that develop housing solutions and supportive services for victims of human trafficking, helping them transition to safe and permanent living situations.

This funding opportunity supports research projects that develop culturally sensitive and effective healthcare interventions for managing multiple chronic diseases in low- and middle-income countries and U.S. Tribal populations.

This grant provides funding to a variety of organizations to improve community engagement and the quality of HIV/AIDS services in Sierra Leone, focusing on enhancing client experiences and health outcomes.