Grants for City or township governments - Science and Technology

The FY24 PCRP Data Science Award mechanism supports research where quantitative and analytical approaches, processes, and/or systems are developed and/or used to obtain knowledge and insight from large and/or complex sets of prostate cancer data. If successful, the studies will enable progress toward addressing one or more of the FY24 PCRP Overarching Challenges. It is expected that any resources, tools, or computational processes generated by this award will be openly shared with the prostate cancer research and patient community. This mechanism is intended to fund research built upon the logic, concepts, and methods of one or more of the following research areas as they pertain to prostate cancer: Computational biology Bioinformatics Artificial intelligence and machine learning Epidemiology Analysis of omics data Medical imaging Digital pathology Analysis of other clinically annotated datasetsApplications may combine diverse data types for integrative analysis to increase knowledge about prostate cancer with respect to the FY24 PCRP Overarching Challenges. Applications that propose to develop resources or tools that allow research, clinical care, and patient community access to standardized and harmonized datasets for real-time clinical care applications are of particular interest; however, this award must not be used to support the development of new datasets. Studies utilizing data derived from large patient studies that include long-term health records or repositories with well-annotated and high-quality biospecimens are encouraged.Key Features: Research Approach: Applications may propose development of a new data-science-driven tool or apply an existing tool or method to gather and analyze information from large datasets with the intent of advancing prostate cancer research and patient care relative to the FY24 PCRP Overarching Challenges. Inclusion of preliminary data to support the scientific rationale and feasibility of research approaches is strongly encouraged, but not required. Any preliminary data provided should be from the laboratory of the Principal Investigator(s) (PI[s]) or member(s) of the collaborating team. Applicants are encouraged to include plans for rigorous validation, benchmarking, comparisons, and/or evaluations to assess the quality or utility of the tools and/or approaches that will be used or developed under this award. Any datasets used in the study design must be from established, retrospective databases and be sufficient in size to provide appropriate analytical and statistical power. Prospective recruitment of human subjects and/or clinical trials is not allowed under this funding opportunity. Applicants are expected to provide documentation demonstrating access to the appropriate datasets and/or patient samples in numbers sufficient to achieve robust results. Impact: Applications are required to clearly communicate how the proposed quantitative and/or analytical approaches, processes, and/or systems will address and provide a solution to one or more of the FY24 PCRP Overarching Challenges. The potential impact of the research, both short- and long-term, should be clearly described, including how the anticipated outcomes or products are distinct from existing research efforts in this area and/or how they will significantly outperform current approaches in this area. High-impact research will, if successful, significantly advance prostate cancer research and/or patient care. Data and Resource Sharing Plan: It is expected that any resources, tools, and computational processes that are developed under this award will be openly shared with the prostate cancer research and patient community. Plans must be provided for how additional data generated by future studies will be incorporated to further inform and refine the data science tools, processes, and/or methods generated and/or used in this study. Refer to the CDMRPs Policy on Data Resource Sharing located on the Electronic Biomedical Research Application Portal (eBRAP) Funding Opportunities Forms web page https://ebrap.org/eBRAP/public/Program.htm for more information about the CDMRPs expectations for making data and research resources publicly available.Partnering PI Option: The FY24 PCRP Data Science Award encourages applications that include meaningful and productive collaborations between investigators. The PIs may have expertise in similar or disparate scientific disciplines, but each PI is expected to bring distinct contributions to the application; collaborations between data scientists and clinicians are highly encouraged. The Partnering PI Option is structured to accommodate two PIs. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI will be identified as a Partnering PI. Both PIs should contribute significantly to the development and execution of the proposed research project, including the Project Narrative, Statement of Work (SOW) and other required components. If recommended for funding, each PI will be named on separate awards to the recipient organization. Each award will be subject to separate reporting, regulatory, and administrative requirements. For individual submission requirements for the Initiating and Partnering PI, refer to Section II.D.2, Content and Form of the Application Submission.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (http://www.nature.com/ nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 PCRP Data Science Award should not exceed $1.0M. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $11.2M to fund approximately seven Data Science Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

The Arizona Water Protection Fund (AWPF) is a competitive state grant program that provides funding to interested parties for the development and implementation of measures to protect water of sufficient quality and quantity to maintain, enhance, and restore river and riparian resources throughout Arizona (including projects that benefit fish and wildlife that are dependent on these important resources), and measures to increase water availability and supply. Financial Notes: Matching funds are not required to be eligible for AWPF funding; however, projects that do include matching funds typically receive higher consideration.   Administrative costs must be limited to a maximum of 5% of the total AWPF project funds requested.  Subcontractors or consultants working on your project must also conform to the 5% administrative cost limit if you are paying them out of AWPF funds.   Payments are made on a cost reimbursement basis.  Appropriate documentation (e.g., receipts, invoices, reports, data, and photographs) will be required in order to receive reimbursement.   Adequate accounting practices and record keeping will be required.

The DARPA Defense Sciences Office grant is aimed at fostering scientific discovery and innovation, anticipating future technological advancements, and understanding global changes to maintain a strategic advantage for the Department of Defense.

The DoD Reconstructive Transplant, Qualitative Research Validation and Implementation Award aims to fund further research and development of resources for the Vascularized Composite Allograft (VCA) community, which were initially created through RTRP-funded qualitative research studies, to enhance their readiness for clinical and community use, with a focus on improving patient outcomes and benefiting population health.

This funding opportunity provides financial support for the construction, maintenance, and improvement of trails and shared-use paths throughout Montana, benefiting local communities and outdoor enthusiasts.

Youth Service America's (YSA) "We Serve to Remember 9/11 Day of Service Grants" program is designed to empower young changemakers aged 5 to 25. This initiative directly aligns with YSA's mission of engaging youth in service and fostering active citizenship. The grants support organizations, schools, and youth changemakers in planning and implementing service activities that honor and pay tribute to those affected by 9/11. The program emphasizes youth leadership, ensuring that projects are driven by the young participants themselves, thereby developing their leadership skills and sense of community responsibility. The program's target beneficiaries are primarily youth, with a strong focus on engaging those who are not typically asked to serve and face systemic barriers to participation. This includes young people of color, youth from underserved low-income families and neighborhoods, and youth who are often beneficiaries of service rather than participants. Specific groups identified include youth in rural communities, those experiencing homelessness, youth in foster care, youth with disabilities, youth in the juvenile justice system, immigrants or refugees, youth from military families, LGBTQ+ youth, and English language learners. The impact goal is to create a more inclusive service environment and empower a diverse group of young people to contribute to their communities. A key priority of this grant program is the engagement of at least 100 youth volunteers per project, with 80% of these volunteers identifying as youth facing systemic barriers to participation. Projects must include elements to honor and pay tribute to those who lost their lives on 9/11, their families, and those who responded in service. All activities must take place on or around September 11th National Day of Service and Remembrance (September 11, 2024). This specific timing reinforces the program's focus on remembrance and national service. YSA expects to award up to 100 grants of $1,000 each. The expected outcomes include a significant increase in youth engagement in service, particularly among marginalized groups, and the successful execution of service activities that commemorate 9/11. Measurable results will include the number of grants awarded, the number of youth volunteers engaged, and the percentage of those volunteers who identify as facing systemic barriers. The program also aims to foster a sense of civic duty and historical awareness among participants. The foundation's strategic priorities are centered on youth empowerment and inclusive participation in service. YSA's theory of change posits that by providing resources and opportunities, particularly to underserved youth, they can develop leadership skills, strengthen communities, and create a lasting impact. By focusing on youth-led projects and ensuring diverse representation, YSA aims to build a generation of civically engaged individuals who are committed to addressing community needs and remembering significant historical events. Applicants must be based in the United States, with activities benefiting people in the U.S., including its territories. This geographical focus ensures that the grants support local communities across the nation. The emphasis on reaching youth who face systemic barriers aligns with a broader strategic goal of promoting equity and inclusion within the service sector, demonstrating YSA's commitment to a more representative and impactful youth service movement.

The Arkansas Department of Finance and Administration (DFA) is offering up to $10.3 million through the Grid Enhancement Grant program, leveraging federal funds from the Infrastructure Investment and Jobs Act (IIJA). This initiative aims to enhance and modernize America's power grid, particularly in Arkansas, by strengthening its resilience against natural disasters and reducing the impact of electric outages. The program is aligned with a broader mission to improve the reliability of the electric grid, protect against outages, and support economic development through grid infrastructure improvements. The primary target beneficiaries of this grant are the residents of Arkansas, especially those in communities more susceptible or vulnerable to electric power outages. The impact goals are to increase grid resilience, reduce the frequency and duration of sustained interruptions, and decrease the number of customers affected by all-hazard events. The program also seeks to encourage investments into the state’s grid workforce, thereby supporting the development of a skilled workforce responsible for these enhancement projects. The DFA's priorities and focuses for this grant are clearly outlined through three main objectives: increasing the reliability of the Arkansas electric grid, achieving whole community impact, and supporting the development of the state’s grid workforce. These objectives aim to reduce outages, ensure benefits reach vulnerable communities, and foster professional and workforce development opportunities for grid enhancement. Expected outcomes include a more resilient electric grid, fewer and less impactful electric outages, and a stronger, more skilled workforce to manage and maintain grid infrastructure. Measurable results would involve a reduction in outage frequency and duration, particularly for high-impact customers, and an increase in the number of trained and retained individuals in the state's grid workforce. The program's strategic priorities are to deliver direct benefits to Arkansans, increase grid resilience, protect against outages during natural disasters, and encourage investments into the state’s grid workforce. This aligns with a theory of change that by investing in adaptive protection, advanced modeling, hardening infrastructure, and workforce development, Arkansas can create a more robust and reliable electric grid that better serves its communities and fosters economic stability.

The Ackley Community Foundation, an affiliate of the Community Foundation of Northeast Iowa, is offering grants to support charitable capital projects, activities, services, programs, and organizations. The core mission of this grant program is to enhance the quality of life for residents of Ackley, Iowa, aligning with the Foundation's broader goal of fostering a community where people desire to live, work, play, and stay. This strategic focus ensures that all funded initiatives contribute directly to the betterment of the local community. The primary beneficiaries of these grants are the people of Ackley, Iowa. The program aims to create a positive and lasting impact across various sectors, including Art and Culture, Community Betterment, Education & Youth Development, Environment and Animal Welfare, Health, and Human Services. The overarching goal is to address community-based needs and improve the overall well-being and vibrancy of Ackley. Funding priorities emphasize requests that demonstrate a clear community need, broad community support, and benefits for the entire community. High priority is also given to organizations that can leverage funding and support from other sources, showcasing matching funds in their budgets. Furthermore, the Foundation values initiatives that maximize community resources through cooperation and collaboration with other local organizations, avoiding service duplication. The capacity of the organization and its staff to achieve desired results, as well as the long-term sustainability of the project without continuous financial reliance on the Ackley Community Foundation, are also critical considerations. Expected outcomes include tangible improvements in the quality of life for Ackley residents, such as enhanced cultural opportunities, stronger community bonds, improved educational outcomes for youth, better environmental stewardship, and increased access to health and human services. The Foundation's theory of change posits that by strategically investing in these key areas, it can catalyze positive social and economic development, leading to a more attractive and thriving community for all its inhabitants. The minimum request amount is $500, with most grants ranging from $500 to $3,000, ensuring a broad range of projects can be supported.

The FY 2024 Good Jobs Challenge grant aims to provide between $1 million to $8 million to 5-8 recipients to support regional workforce training systems that promote job placement and industry advancement in key technology areas, thereby enhancing the economic and national security of the United States.

This program provides funding to educational institutions and organizations to develop innovative strategies that increase the participation of underrepresented groups in computing fields, such as women and minorities.

With this solicitation, NIJ, in collaboration with the Bureau of Justice Assistance, seeks applications for funding rigorous research and evaluation projects to fill knowledge gaps in two topical areas: 1) studies on the root causes and consequences of school violence and 2) examinations of the impact and effectiveness of awards made for purposes authorized under the STOP School Violence Act. OJP is committed to advancing work that promotes civil rights and equity, increases access to justice, supports crime victims and individuals impacted by the justice system, strengthens community safety and protects the public from crime and evolving threats, and builds trust between law enforcement and the community.

This solicitation is offered for support of two types of projects, a TCUP Hub and faculty-led topical interest groups (TIGs). The TCUP Hub will serve the entire TCUP-eligible community with activities such as convening workshops (including the TCUP Leaders' Forum), coordinating faculty/student exchanges, organizing professional development opportunities, and overseeing TCUP Fellowship opportunities with eligible agencies. The Hub will connect people and organizations to facilitate relationships, expand and diversify networks, and support TCUP faculty and staff in building capacity in areas they identify. It will curate shared resources, expertise, and experiences to build the capacity of TCUP institutions. Also, it will build and support a sense of community among all TCUP institutions and elevate the voices within them. Only one Hub will be supported, either to a single institution or to a collaborative submission from multiple institutions. Interested parties may find that a collaborative submission from multiple institutions is more feasible, engaging two or more TCUP institutions to synergistically leverage their different strengths in realizing the Hub's mission. Multiple institutions submitting collaboratively may better address the multiplicity of TCUP institutions, which vary geographically, administratively, and in modes of governance. Clearly, some activities may be best pursued by enlisting specialists as consultants. Two types of collaborative proposals are acceptable: simultaneous submission of proposals from multiple organizations submitting a unified set of certain proposal sections, as well as information unique to each organization, such as unique budgets, key personnel, and activities; or submission of a collaborative proposal from one organization, with collaborating institutions included through subawards (subawards are permitted only to TCUP-eligible institutions; proposers should confer with the TCUP program staff prior to submission). All collaborative proposals submitted from multiple organizations must be submitted via Research.gov. Additionally, this solicitation is offered for support of independent, faculty-led topical interest groups (TIGs) that focus on professional development of faculty and formation of science, technology, engineering, and mathematics (STEM) discipline networks (e.g., engineering, genomics, Indigenous research, environmental science). Up to two new TIGs may be supported. [1] Executive Order 13021 defines Tribal Colleges and Universities ("tribal colleges") as those institutions cited in section 532 of the Equity in Educational Land-Grant Status Act of 1994 (7 U.S.C. 301 note), and other institutions that qualify for funding under the Tribally Controlled Community College Assistance Act of 1978, (25 U.S.C. 1801 et seq.), as well as Navajo Community College as authorized in the Navajo Community College Assistance Act of 1978, Public Law 95-471, Title II (25 U.S.C. 640a note). The term "Alaska Native-serving institution" means an institution of higher education that is an eligible institution under section 1058(b) of the Higher Education Act; and that, at the time of submission, has an undergraduate enrollment that is at least 20 percent Alaska Native students. The term "Native Hawaiian-serving institution" means an institution of higher education that is an eligible institution under section 1058(b) of the Higher Education Act; and that, at the time of submission, has an undergraduate enrollment that is at least 10 percent Native Hawaiian students. Most TCUP-eligible institutions of higher education are two-year or community colleges. See the Who May Submit Proposals section in this solicitation for further details.

This funding opportunity provides financial support for research and evaluation projects aimed at improving youth justice systems, focusing on prosecution, defense delivery, reentry practices, and system reforms to better serve justice-involved youth.

This funding opportunity provides financial support to local governments in Illinois for water and sanitary system projects that improve public health and safety in communities with significant low-to-moderate income populations.

This grant provides funding to non-profit and community organizations in East Knoxville to promote equity and address disparities in areas such as education, homeownership, and small business development.

The Minnesota Pollution Control Agency (MPCA) invites proposals for a community air monitoring pilot grant program, targeting neighborhood-scale air quality monitoring in the Twin Cities metro area. Eligible organizations, primarily community nonprofits and their partners, will develop a dense network of fixed and mobile air sensors. Priority will be given to projects in environmental justice communities with robust community engagement. The objectives include monitoring air quality, fostering community cooperation, and providing actionable air quality data to MPCA. The application deadline is 4:30 p.m. Central Time on June 28, 2024.

This funding opportunity provides financial support to public and nonprofit organizations for managing fire science exchanges that deliver critical fire management information to stakeholders in six specific regions across the United States.

The FY24 PCRP Physician Research Award supports a mentored research experience to prepare physicians with clinical duties and/or responsibilities for productive careers in prostate cancer research. The mentored physician is considered the Principal Investigator (PI) of the application. This award emphasizes equally the quality of the proposed research project and the career development of the PI, which should prepare physicians for careers in basic, population science, translational, or clinical prostate cancer research. All applications for the FY24 PCRP Physician Research Award are to be written by the PI, with appropriate direction from the mentor(s).Key elements of this award mechanism are as follows: Principal Investigator: Physicians with clinical duties and/or responsibilities who, at the application submission deadline, are either in the last year of an accredited graduate medical education program as a resident or fellow or within 5 years of having initiated a faculty appointment (including Instructor positions) are eligible to apply. The PI must demonstrate a commitment to a career as a physician-scientist and investigator at the forefront of prostate cancer research and clinical practice; however, the PI is not required to have previous prostate cancer research experience. The award is intended to provide protection of the PIs time for prostate cancer research. Applications are strongly encouraged to demonstrate protection of at least 20% of the PIs time for prostate cancer research, which is not required to be exclusive to this award but can include effort dedicated to other prostate cancer research projects. Mentor(s): This award requires the involvement of at least one designated mentor with an established research program in prostate cancer, as evidenced by recent publications, active funding, and successful mentorship. In addition, the mentor(s) must demonstrate a commitment to advancing the PIs career in prostate cancer research. Research Approach: Proposed research ideas are required to address one or more of the FY24 PCRP Overarching Challenges. The scientific rationale and experimental methodology should demonstrate in-depth analysis of the research problem presented. The feasibility of the research design and methods should be well defined, and a clear plan should be articulated as to how the proposed goals of the project can be achieved. The inclusion of preliminary data relevant to prostate cancer and the proposed project is encouraged but not required. Any preliminary data provided should be from the PI, mentor(s), or member(s) of the collaborating team. Additionally, required resources should be identified and supported through documentation. Research involving human subjects is permitted under this funding opportunity but is restricted to studies without clinical trials. Correlative studies associated with an existing clinical trial are particularly encouraged, provided they are determined to be no greater than minimal risk by the Institutional Review Board (IRB) of record and the USAMRDC Office of Human and Animal Research Oversight (OHARO), Office of Human Research Oversight. Researcher Development Plan: An individualized researcher development plan is required and should be prepared with appropriate guidance from the mentor(s). The researcher development plan should include a clearly articulated strategy for acquiring the necessary skills, competence, and expertise that will enable the PI to successfully complete the proposed research project and foster the PIs development as an independent prostate cancer physician-scientist. An environment appropriate to the proposed mentoring and research project must be clearly described, although any deficiencies of resources and/or mentorship at the PIs institution can be mitigated through collaboration(s) with other institutions. If the PI will be utilizing resources at another institution to successfully complete the proposed project, then the PI is strongly encouraged to designate a co-mentor at the collaborating institution. Impact: The proposed research must address and provide a solution to one or more of the FY24 PCRP Overarching Challenges and ultimately should have the potential to make a significant impact on the programs mission of eliminating death and suffering from prostate cancer and enhancing the well-being of Service Members and their Families, Veterans, and all the patients and caregivers who are experiencing the impact of the disease.Investigators are strongly encouraged to incorporate the following components into their study design, where appropriate, in order to maximize the potential impact of the proposed research project: authentication of proposed cell lines; statistical rigor of preclinical animal experiments; and incorporation of experiments to assess clinical relevance and translatability of findings. Studies utilizing data that are derived from large patient studies that include long-term health records, biospecimen repositories, and pre-existing research and apply state-of-the-art genomic and/or proteomic analysis, bioinformatics, and/or mathematical models to such data are also encouraged. Investigators are highly encouraged to provide a letter of support indicating access to and the availability of any resources required to support the study.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, the CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 PCRP priorities.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more-effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/ journal/v490/n7419/full/nature11556.html. While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.For the purposes of this funding opportunity, research that meets the definition of a clinical trial is distinct from clinical research. Clinical research encompasses research with human data, human specimens, and/or interaction with human subjects. Clinical research is observational in nature and includes:(1) Research conducted with human subjects and/or material of human origin such as data, specimens, and cognitive phenomena for which an investigator (or co-investigator) does not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention. Research meeting this definition may include but is not limited to: (a) mechanisms of human disease, (b) diagnostic or detection studies (e.g., biomarker or imaging), (c) health disparity studies, and (d) development of new technologies.(2) Epidemiologic and behavioral studies that do not seek to assess the safety, effectiveness, and/or efficacy outcomes of an intervention.(3) Outcomes research and health services research that do not fit under the definition of clinical trial.Excluded from the definition of clinical research are in vitro studies that utilize human data or specimens that cannot be linked to a living individual and meet the requirements for exemption under 46.104(d)(4) of the Common Rule.The funding instrument for awards made under the program announcement will be grants (31 USC 6304).The anticipated direct costs budgeted for the entire period of performance for an FY24 PCRP PRA Award should not exceed $750,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.Awards supported with FY24 funds will be made no later than September 30, 2025.The CDMRP expects to allot approximately $4.80M to fund approximately four PCRP Physician Research Award applications. Funding of applications received is contingent upon the availability of federal funds for this program, the number of applications received, the quality and merit of the applications as evaluated by peer and programmatic review, and the requirements of the government. Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY24 funding opportunity will be funded with FY24 funds, which will expire for use on September 30, 2030.

This funding opportunity supports research and evaluation projects that address the needs of special populations in corrections, improve workforce management, and enhance correctional culture and safety, inviting a wide range of organizations to collaborate on innovative solutions.