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Grants for Small businesses - Science and Technology

Explore 1,029 grant opportunities

DoD Peer Reviewed Medical, Clinical Trial Award
$90,000,000
Department of Defense - Dept. of the Army -- U.S.AMRAA
Federal

Application Deadline

Aug 19, 2024

Date Added

Mar 27, 2024

The FY24 PRMRP Clinical Trial Award supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of a disease or condition addressed in one of the congressionally directed FY24 PRMRP Topic Areas and FY24 PRMRP Strategic Goals. Clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. Proposed projects may range from small proof-of-concept trials (e.g., pilot, first in human, phase 0) to demonstrate the feasibility or inform the design of more advanced trials through large-scale phase 1 to phase 3 trials to determine efficacy in relevant patient populations.Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the U.S. Department of Veterans Affairs (VA), and other federal government agencies are highly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health.Funding from this award mechanism must support a clinical trial. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes. Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.

Science and Technology
Nonprofits
ROSES 2025: A.5 Earth Venture Suborbital-4 Snow4Flow Science Team
$5,000,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Sep 9, 2025

Date Added

Jul 12, 2025

This funding opportunity is designed for researchers and teams focused on improving our understanding of snow accumulation and ice flow dynamics in glaciers across the Northern Hemisphere, with an emphasis on airborne and ground-based observations, modeling, and data synthesis.

Environment
Public and State controlled institutions of higher education
COVID-19 ARPA Digital Connectivity Technology Program
$20,000,000
Pennsylvania Department of Community and Economic Development
State

Application Deadline

Dec 31, 2026

Date Added

May 15, 2024

This program provides funding for community organizations and local governments to acquire technology devices to help bridge the digital divide for those facing affordability challenges.

Health
City or township governments
Division of Physics: Investigator-Initiated Research Projects
$120,000,000
National Science Foundation
Federal

Application Deadline

Dec 9, 2025

Date Added

Sep 12, 2025

This funding opportunity provides financial support for a wide range of physics research projects at U.S. institutions, including universities and nonprofit organizations, to advance knowledge in various subfields of physics.

Science and Technology
Public and State controlled institutions of higher education
Department of Army Energetics Basic Research Center (EBRC) Fiscal Year 2025
$500,000
U.S. Department of Defense (Dept of the Army -- Materiel Command)
Federal

Application Deadline

Apr 7, 2025

Date Added

Oct 1, 2024

This funding opportunity is designed to support research institutions and organizations in developing innovative energetic materials and methods to enhance the Army's capabilities in weapon systems and multi-domain operations.

Science and Technology
Public and State controlled institutions of higher education
Combination Therapies for Parkinson’s Funding Call
$1,344,500
Cure Parkinson’s
Private

Application Deadline

Jan 26, 2026

Date Added

Oct 2, 2025

This funding opportunity provides £2 million for researchers worldwide to develop and test combination drug therapies that could slow, stop, or reverse Parkinson's disease progression.

Health
Individuals
Workforce and Business Development
$28,000,000
California Department of Forestry and Fire Protection
State
Rolling

Application Deadline

Not specified

Date Added

Sep 18, 2023

CAL FIRE's Wood Products and Bioenergy team seeks to maintain and enhance the wood products infrastructure of California to promote healthy resilient forests throughout the state by supporting a diverse set of business development and workforce development projects.  ; Eligible business development projects include facilities, operations, and professional services that support the restoration of healthy, resilient forests.   Eligible workforce development projects include universities, colleges, government and community organizations, and businesses that aim to increase workforce capacity in the fields of logging, fuels treatment, transportation, manufacturing, or other support services that bolster the development of a resilient forest sector workforce.   Research and development projects related to both business and workforce development will also be considered. Check out the Wood Products website and subscribe for updates.     

Diversity Equity and Inclusion
Small businesses
University Leadership Initiative (ULI)
Contact for amount
NASA-HQ (NASA Headquarters)
Federal

Application Deadline

May 29, 2024

Date Added

Mar 1, 2024

Amendment 2 to the NASA ARMD Research Opportunities in Aeronautics (ROA) 2024 NRA has been posted on the NSPIRES web site. University Leadership Initiative (ULI) provides the opportunity for university teams to exercise technical and organizational leadership in proposing unique technical challenges in aeronautics, defining multi-disciplinary solutions, establishing peer review mechanisms, and applying innovative teaming strategies to strengthen the research impact.Research proposals are sought in six ULI topic areas in Appendix D.4.Topic 1: Safe, Efficient Growth in Global Operations (Strategic Thrust 1)Topic 2: Innovation in Commercial High-Speed Aircraft (Strategic Thrust 2)Topic 3: Ultra-Efficient Subsonic Transports (Strategic Thrust 3) Topic 4: Safe, Quiet, and Affordable Vertical Lift Air Vehicles (Strategic Thrust 4)Topic 5: In-Time System-Wide Safety Assurance (Strategic Thrust 5)Topic 6: Assured Autonomy for Aviation Transformation (Strategic Thrust 6)This NRA will utilize a two-step proposal submission and evaluation process. The initial step is a short mandatory Step-A proposal due May 29, 2024. Those offerors submitting the most highly rated Step-A proposals will be invited to submit a Step-B proposal. All proposals must be submitted electronically through NSPIRES at https://nspires.nasaprs.com.An Applicants Workshop will be held on Thursday Apr 3, 2024; 1:00-3:00 p.m. ET (https://uli.arc.nasa.gov/applicants-workshops/workshop8).An interested partners list for this ULI is at https://uli.arc.nasa.gov/partners. To be listed as an interested lead or partner, please send electronic mail to [email protected] with "ULI Partnerships" in the subject line and include the information required for the table in that web page.

Science and Technology
Nonprofits
Spinal Cord Injury and Traumatic Brain Injury Research Grant Program - Tier 2 Standard Research Grant
$250,000
Minnesota Office of Higher Education
State

Application Deadline

May 22, 2024

Date Added

Apr 19, 2024

This grant option, part of the Minnesota Spinal Cord Injury and Traumatic Brain Injury Research Grant Program, aims to support early-stage research into innovative treatments and rehabilitative techniques for spinal cord and traumatic brain injuries. The Tier 1 Pilot Project Grant does not require preliminary data but encourages it, reflecting early investment as researchers prepare to seek larger grants. The funding amount can reach up to $125,000 for a project duration of two years with an additional one-year no-cost extension.

Health
Nonprofits
Legacy Business Recovery Grant Program
$20,000
Economic & Workforce Development Department (EWDD)
Local

Application Deadline

Sep 15, 2024

Date Added

Aug 8, 2024

The Legacy Business Recovery Grant Program, funded by the American Rescue Plan Act (ARPA) allocation to the City of Los Angeles, offers grants of up to $20,000 to eligible Legacy Businesses. This initiative is designed to provide crucial financial assistance to aid these businesses in their recovery from the economic impacts of the COVID-19 pandemic. The program's core mission aligns with broader efforts to support local economies and preserve established community businesses, recognizing their historical and cultural value. It underscores a commitment to helping businesses adapt, reopen, and sustain operations in a challenging economic landscape. The primary beneficiaries of this program are Legacy Businesses listed on the Legacy Business Registry, operating within Los Angeles city limits, and functioning from commercial, industrial, or manufacturing locations with a valid commercial lease. Home-based businesses are not eligible, and annual revenue cannot exceed $3 million. The impact goal is to facilitate the recovery and continued operation of these vital businesses, ensuring their survival and contribution to the local economy and community fabric. Businesses must demonstrate how the funds will be used for COVID-19 recovery expenses, with a focus on necessary expenditures. Funding priorities emphasize equitable distribution across finalists, with a particular focus on City of Los Angeles geographic diversity and low-to-moderate income neighborhoods. Grant application submissions from businesses located in or owned by individuals in low- and moderate-income communities (50% and 80% of Area Median Income as defined by HUD) are more heavily weighted, as are businesses facing an imminent threat of displacement. This weighted selection process reflects a strategic priority to support businesses in areas with greater need and vulnerability, aligning with a theory of change that targeted investment can produce more equitable and impactful recovery outcomes. Expected outcomes include the sustained operation of Legacy Businesses, job retention, and economic stabilization within affected communities. Measurable results will be tied to how grant funds are utilized, with eligible uses encompassing employee payroll, rent, utilities, insurance, working capital for reopening or continued operations, adapting to new technologies, payment of outstanding business expenses incurred after March 3, 2021, adaptive business practices, and legal fees for lease negotiations. Grant amounts are tiered based on employee count: $10,000 for businesses with one to five employees and $20,000 for those with six or more. This structure ensures that assistance is tailored to the operational scale of the businesses, contributing to their effective recovery and resilience.

Business and Commerce
Small businesses
Biological Technologies
Contact for amount
DOD-DARPA-BTO (DARPA - Biological Technologies Office)
Federal

Application Deadline

Jun 20, 2024

Date Added

Jun 22, 2023

This announcement seeks revolutionary research ideas for topics not being addressed by ongoing BTO programs or other published solicitations. This publication constitutes a Broad Agency Announcement (BAA) as contemplated in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016 and 2 CFR § 200.203. Any resultant award negotiations will follow all pertinent law and regulation, and any negotiations and/or awards for procurement contracts will use procedures under FAR 15.4, Contract Pricing, as specified in the BAA. BTO's mission is to develop capabilities that leverage the unique properties of biology - adaption, replication, resilience and complexity, to revolutionize how the United States defends the homeland and prepares and protects its Warfighters. Research in BTO creates biotechnological capabilities that provide tactical care and restore function to injured warfighters, increase operational resilience, develop novel functional materials, and detect and protect against threats to maintain force readiness.

Science and Technology
Public and State controlled institutions of higher education
DRL Internet Freedom Annual Program Statement
$3,000,000
U.S. Department of State (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Jan 9, 2025

Date Added

Oct 3, 2024

This grant provides funding for organizations to develop projects that promote internet freedom, protect human rights online, and combat censorship and digital security threats.

Science and Technology
Nonprofits
NSF National Resource Coordination Center on Improving Undergraduate STEM Education (IUSE)
$7,500,000
National Science Foundation
Federal

Application Deadline

Nov 14, 2024

Date Added

Aug 16, 2024

This grant provides funding to establish a center that will support and connect educators and researchers focused on improving undergraduate STEM education across the nation.

Science and Technology
For profit organizations other than small businesses
Michigan Maritime Strategy
$200,000
Michigan Department of Environment, Great Lakes, and Energy (EGLE)
State

Application Deadline

Not specified

Date Added

Jun 14, 2024

This grant provides funding to organizations and institutions to develop a comprehensive maritime strategy for Michigan that promotes sustainability, equity, and environmental justice in the state's shipping and boating sectors.

Environment
Nonprofits
Energy Storage Innovations Prize
$50,000
U.S. Department of Energy (DOE) Office of Electricity (OE)
Federal

Application Deadline

Sep 10, 2025

Date Added

Dec 31, 2024

This grant provides funding for individuals and organizations to develop innovative energy storage solutions that cater to unique applications in underserved communities and extreme climates, promoting grid modernization and reliability.

Science and Technology
Small businesses
COVID-19 ARPA PA Broadband Infrastructure Program
$200,000,000
Pennsylvania Department of Community and Economic Development
State

Application Deadline

Not specified

Date Added

Mar 22, 2024

This program provides $200 million in competitive funding to improve broadband access in underserved areas lacking reliable internet service of at least 25/3 Mbps.

Health
Small businesses
COVID-19 Vaccines, Treatments, and Therapies (CV-VTT)
$10,000,000
Pennsylvania Department of Community and Economic Development
State

Application Deadline

Not specified

Date Added

Mar 15, 2024

The Coronavirus Aid, Relief, and Economic Security (CARES) Act was signed into law on March 27, 2020. The $2 trillion economic relief package aims to protect the American people from the public health and economic impacts of COVID-19. Act 2A of 2020, known as the COVID-19 Emergency Supplement to the General Appropriation Act of 2019, appropriated $10,000,000 from the COVID-19 Response Restricted Account to the Department of Health. Through a sub-grant, the Department of Community and Economic Development will administer this program to eligible applicants for the rapid advancement of vaccines, treatments, and therapies in response to COVID-19. Financial Info: The Coronavirus Aid, Relief, and Economic Security (CARES) Act was signed into law on March 27, 2020. The $2 trillion economic relief package aims to protect the American people from the public health and economic impacts of COVID-19. Act 2A of 2020, known as the COVID-19 Emergency Supplement to the General Appropriation Act of 2019, appropriated $10,000,000 from the COVID-19 Response Restricted Account to the Department of Health. Through a sub-grant, the Department of Community and Economic Development will administer this program to eligible applicants for the rapid advancement of vaccines, treatments, and therapies in response to COVID-19.

Health
Small businesses
DoD Ovarian Cancer Ovarian Cancer Academy Early-Career Investigator Award
$2,320,000
U.S. Department of Defense - Dept. of the Army -- U.S.AMRAA
Federal

Application Deadline

Aug 6, 2024

Date Added

Mar 28, 2024

Initially created in FY09, the OCRP Ovarian Cancer Academy (OCA) is a unique, interactive virtual academy providing intensive mentoring, national networking, collaborations, and a peer group for junior faculty. The overarching goal of the OCA is to develop successful, highly productive ovarian cancer researchers in a collaborative research and career development environment.The OCA is a virtual career development and research training platform that consists of Early-Career Investigators (ECIs), their Designated Mentors from different institutions, and an Academy Dean and Assistant Dean. The OCA-ECI Award is not a traditional career development award; the ECI is expected to participate in monthly webinars and annual workshops and to communicate and collaborate with other members of the Academy (other ECIs, Mentors, the Dean and Assistant Dean) as well as with the advocacy community. Since its inception, the Academys ECIs have presented at and chaired sessions for ovarian cancer-specific symposia and served on symposia review committees. They have also served as peer reviewers for the Department of Defense (DOD) OCRP and other funding agencies.Pre-Application (Preproposal) Submission Deadline: 5:00 p.m. Eastern time (ET), May 14, 2024 • Invitation to Submit an Application: June 17, 2024 • Application Submission Deadline: 11:59 p.m. ET, August 6, 2024 • End of Application Verification Period: 5:00 p.m. ET, August 9, 2024 • Peer Review: October 2024 • Programmatic Review: December 2024

Science and Technology
Nonprofits
North St. Louis Commercial Corridor Grant Program
$37,000,000
City of St. Louis
Local
Rolling

Application Deadline

Not specified

Date Added

Dec 6, 2023

The North St. Louis Commercial Corridor Grant Program in Missouri has been allocated $37 million of Coronavirus State and Local Fiscal Recovery Funds for administration by the St. Louis Development Corporation. The program includes Community Need Grants for small businesses and nonprofits located in a HUD Qualified Census Tract within a neighborhood containing part of one of the North St. Louis Commercial Corridors, as well as Small Business Stabilization & Expansion Grants for operational support and business growth. Additionally, there is a Façade and Storefront Improvements Program aimed at enhancing the value of businesses and improving the quality of customer experience in North St. Louis neighborhoods.

Health
Nonprofits
Tourism Product Development Grant Program
$20,000
Chautauqua County
Local

Application Deadline

Oct 1, 2024

Date Added

Aug 14, 2024

The Chautauqua County Tourism Product Development Grant Program, with a deadline of 10/01/2024, offers $10,000 to $100,000 for projects that enhance tourism and recreation opportunities, increase visibility, and promote overnight stays in the county, with a focus on event development, marketing, and attraction enhancement.

Science and Technology
Nonprofits