Grants for Small businesses - Science and Technology

This funding opportunity is designed to support innovative research and development projects that enhance military logistics, supply chain resilience, and operational readiness for the Department of Defense.

The 2024-25 Physical and Digital Infrastructure Security Grant (DF) Program for Health Care Facilities, offered by the California Governor’s Office of Emergency Services (Cal OES), aims to enhance physical and digital security for healthcare facilities in California. This program aligns with the foundational mission of protecting vital health services and ensuring the safety of facilities that provide abortion-related and reproductive healthcare, which are often targets of violence and vandalism. The grant seeks to mitigate these threats, thereby supporting the continuity and accessibility of critical healthcare services across the state. The target beneficiaries of this grant are currently licensed community health centers, tribal health programs, non-profit hospitals not part of large health systems, and non-profit organizations whose membership includes such licensed facilities. All eligible applicants must be located in California and provide abortion-related services (or referrals) and reproductive healthcare services. The impact goal is to strengthen the security infrastructure of these facilities, creating safer environments for both patients and staff, and ensuring uninterrupted access to essential healthcare. The program's priorities and focuses include providing funding for physical facility enhancements, such as improved security measures for buildings, and digital security enhancements to protect against cyber threats and data breaches. The grant specifically targets facilities that may be vulnerable to violence and vandalism due to the nature of the services they provide. The funding aims to directly address these vulnerabilities, thereby safeguarding the operational capacity of these crucial healthcare providers. Expected outcomes and measurable results include a demonstrable improvement in the physical and digital security posture of funded facilities. This could involve a reduction in incidents of vandalism or violence, enhanced data protection, and increased patient and staff safety. The grant period is from September 1, 2024, through December 31, 2026, during which time facilities are expected to implement and integrate these security upgrades. Applicants can request up to $750,000 from the total available funding of $7,798,822. While specific "Foundation's strategic priorities and theory of change" are not explicitly detailed for Cal OES in the provided text, the underlying theory of change for this grant program appears to be that by providing targeted funding for security enhancements, the state can directly reduce risks to essential healthcare infrastructure. This proactive investment is expected to lead to greater resilience for healthcare facilities, particularly those offering sensitive services, thereby upholding public health and safety and ensuring that all Californians have access to necessary medical care without fear or disruption.

The FY24 PRMRP Lifestyle and Behavioral Health Interventions Research Award (LBIRA) supports clinical research and/or clinical trials using a combination of scientific disciplines including behavioral health, psychology, psychometrics, biostatistics and epidemiology, surveillance, and public health. Applications are required to address and provide a solution to one of the congressionally directed FY24 PRMRP Topic Areas and FY24 PRMRP Strategic Goals.The overall intent of the FY24 PRMRP LBIRA mechanism is to promote evidence-based and patient-centered approaches to improve health and/or disease-related outcomes and enhance the patient experience in defined populations. Research ideas may include, but are not limited to: Development and testing for efficacy of lifestyle interventions and symptom management approaches to minimize disease risk and maximize quality of life. Studies to investigate the impact of prevention, diagnostics, treatment, or health care delivery approaches on health outcomes. Studies to assess the relationship(s) between behavioral, cognitive, and/or social functioning in relation to disease or condition initiation, progression, detection, treatment, and rehabilitation. Studies to examine and improve quality of life or decision-making. Population-focused studies to identify behavioral and lifestyle predictors of disease and/or disease progression.Pre-Application (Letter of Intent) Submission Deadline: 5:00 p.m. Eastern time (ET), May 13, 2024

LIGHT intends to shine a light on the lymphatic system, illuminating the unseen both literally via novel diagnostic approaches and figuratively through insight gained into the critical role the lymphatic system plays in health as well as its impacts when dysfunctional. LIGHT aims to improve the lives of tens of millions of Americans by creating agile tools that are scalable, accessible, accurate and clinically useful to detect lymphatic structure and function. Multiple diagnostic technologies will enable targeted interventions that result in better patient outcomes and reduced treatment costs, and will advance our understanding of lymphatic dysfunction, a key factor in the pathophysiology of many important diseases. Signs and symptoms of lymphatic dysfunction do not manifest until the disease has progressed, and current assessment tools neither adequately appraise lymphatic anatomy nor measure lymphatic function. The Government reserves the right to select for negotiation all, some, one, or none of the proposals received in response to this ISO. If warranted, portions of resulting awards may be segregated into prepriced options. In the event the Government desires to award only portions of a proposal, negotiations will commence upon selection notification. The Government reserves the right to fund proposals in phases with options for continued work, as applicable. The Government reserves the right to request any additional, necessary documentation to support the negotiation and award process. The Government reserves the right to remove a proposal from award consideration should the parties fail to reach agreement on award terms, conditions, cost, and/or if the proposer fails to provide requested additional information in a timely manner. In all cases, the Government will have sole discretion to negotiate all instrument terms and conditions with selectees. ARPA-H will apply publication or other restrictions, as necessary, if it is determined that the research resulting from the proposed effort will present a high likelihood of disclosing sensitive information including Personally Identifiable Information (PII), Protected Health Information (PHI), financial records, proprietary data, any information marked Sensitive but Unclassified (SBU), etc. Any award resulting from such a determination will include a requirement for ARPA-H concurrence before publishing any information or results on the effort. ARPA-H seeks proposals from all eligible entities (see Section 2 Eligibility Information) to accomplish the LIGHT Program goals as described in this solicitation package. Ultimately, ARPA-H intends to negotiate multiple Other Transaction agreements (OTs) and/or Cooperative Agreements (CAs) with proposers whose proposals are most advantageous to the Government and are poised to meet the goals of the LIGHT program. Proposals are expected to use innovative approaches that may include both existing and novel technology, enabling revolutionary advances in medicine and healthcare. The LIGHT program aims to develop a comprehensive diagnostic toolkit to assess lymphatic structure and function, and potential performers should consider an approach to ensure the final technology includes an imaging modality plus biomarkers and/or genetic integration. Initially proposers should consider primary lymphatic 5 diseases as the targeted disease state; however, consideration of other chronic conditions associated with lymphatic dysfunction is encouraged. Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art, including clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

The Minnesota Pollution Control Agency is offering a grant of over $1 million to public, private, and nonprofit owners of heavy-duty diesel vehicles in Minnesota to replace their old vehicles with new, cleaner models, aiming to reduce diesel emissions and improve air quality.

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email [email protected] (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email [email protected]. Agency Overview: The Advanced Research Projects Agency Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260): (A) to enhance the economic and energy security of the United States through the development of energy technologies that (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies. ARPA-E issues this Funding Opportunity Announcement (FOA) under its authorizing statute codified at 42 U.S.C. 16538. The FOA and any cooperative agreements or grants made under this FOA are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on, and the development of, transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established learning curves where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive improvements to the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. In contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly better than that of the incumbent technology. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development. The Office of Management and Budget defines applied research as an original investigation undertaken in order to acquire new knowledgedirected primarily towards a specific practical aim or objective and defines experimental development as creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes. Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts) should contact the DOEs Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy and Carbon Management (https://www.energy.gov/fecm/office-fossil-energy-and-carbon-management), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity (https://www.energy.gov/oe/office-electricity). SBIR/STTR Program Overview: The Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs are Government-wide programs authorized under Section 9 of the Small Business Act (15 U.S.C. 638). The objectives of the SBIR program are to (1) stimulate technological innovation in the private sector, (2) strengthen the role of Small Business Concerns in meeting Federal R needs, (3) increase private sector commercialization of innovations derived from Federal R activities, (4) foster and encourage participation by socially and economically disadvantaged and women-owned Small Business Concerns, and (5) improve the return on investment from Federally funded research and economic benefits to the Nation. The objective of the STTR program is to stimulate cooperative partnerships of ideas and technologies between Small Business Concerns and partnering Research Institutions through Federally funded R activities. ARPA-E administers a joint SBIR/STTR program in accordance with the Small Business Act and the SBIR and STTR Policy Directive issued by the U.S. Small Business Administration (SBA). ARPA-E provides SBIR/STTR funding in three phases (Phase I, Phase II, and Phase IIS). Program Overview: The Technologies to Emend and Obviate SYnthetic Nitrogens Toll on Emissions (TEOSYNTE) program aims to lower nitrous oxide (N2O) emissions from the cultivation of corn and sorghum used for United States ethanol production by 50%. The program will emphasize plant and microbial bio-design strategies that lower the application of synthetic nitrogen (N) fertilizer on corn and sorghum fields while maintaining crop yields and reducing 50% of N2O emissions. Lowering the requirements of synthetic N fertilizer will also lower costs to farmers, as the cost of fertilizer is a significant portion of the operating expenses of a farm. This program will enable technologies to reduce N fertilizer consumption and N2O emissions. These technologies will transform agriculture and lower the N2O contribution to the carbon intensity (CI) of ethanol produced today for light duty vehicles and in the future for sustainable aviation fuel. Technologies developed under the TEOSYNTE program must achieve specific targets as outlined in Section I.E. in order to meet the programs objectives to reduce greenhouse gas (GHG) emissions and N fertilizer usage over multiple seasons while maintaining crop yields. To view the FOA in its entirety, please visit https://arpa-e-foa.energy.gov.

Funding available through this RFA supports the ongoing research and development of new and emerging technologies for the detection, diagnosis, prognosis, monitoring, or treatment of cancer. CPRIT created this RFA to fund new and emerging technology projects that do not easily fit into any of the three other CPRIT Product Development Research RFAs. Proposals may include, but are not limited to, bioinformatics, artificial intelligence, production of radionuclides or their precursors, manufacture of cell-based therapies, processes to improve the quality of the samples used for cancer research or clinical care, and biomanufacturing of therapeutics. With appropriate justification, companies may use CPRIT funds to support studies that establish preclinical proof of concept, product validation, design, production, manufacturing and development, and clinical studies demonstrating safety and efficacy.

The DoD Bone Marrow Failure, Idea Development Award is a funding opportunity aimed at supporting innovative and scientifically sound research ideas that contribute to understanding and curing bone marrow failure diseases, with a particular emphasis on hypothesis-driven studies linked to clinical trials, open to both established and early-career investigators.

This funding opportunity supports small businesses in developing innovative products and services that improve the health, employment, and community participation of individuals with disabilities.

This grant provides funding to early-career researchers dedicated to innovative breast cancer research, emphasizing transformative approaches and collaboration with breast cancer survivors.

This program provides matching funds to small businesses in North Carolina that have received federal SBIR or STTR awards, helping them develop and commercialize innovative technologies.

This grant provides funding for researchers and organizations to analyze data from Mars missions, supporting advancements in our understanding of the planet's geology, climate, and potential for life.

This program provides funding and support to small businesses in Pennsylvania that are historically disadvantaged, helping them access capital and improve their participation in public contracts.

This grant provides funding for collaborative research teams of independent investigators to advance innovative solutions in melanoma prevention, treatment, and survivorship, with a focus on improving patient outcomes.

This program provides free technical assistance to small Pennsylvania businesses to help them improve their operations and competitiveness by connecting them with expert resources and solutions for specific technical challenges.

The DoD Tick-Borne Disease, Idea Development Award is a grant aimed at funding innovative research that could significantly advance the understanding and treatment of Lyme disease and other tick-borne diseases, ultimately improving the lives of military personnel, veterans, their families, and the general public.

This funding opportunity is designed to support innovative citizen science projects that engage the public in space and Earth science research, encouraging collaboration between scientists and community members.

This program provides support, mentorship, and funding to early-stage cleantech startups in Tennessee and surrounding regions to help them commercialize innovative technologies.

This grant provides funding for researchers studying ancient sediments and fossils to better understand the Earth's history, environmental changes, and the evolution of life before the Holocene epoch.

The Federal and State Technology (FAST) Partnership Program provides funding to organizations to execute state/regional programs that increase the number of SBIR/STTR proposals leading to an increase in the number of SBIR/STTR awards from women, socially/economically disadvantaged individuals, and small businesses in underrepresented areas - typically rural states.