Grants for City or township governments - Federal

The "Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01) Clinical Trials Required" grant aims to fund clinical trials that test the effectiveness and safety of new treatments for rare diseases, with the goal of increasing the number of approved treatments for these conditions.

This grant provides funding for collaborative research teams to develop and test strategies that address and reduce racial and ethnic disparities in substance use and addiction, prioritizing community-driven issues.

The RFSP supports partnerships that connect public and private resources to plan and develop local or regional food systems. The RFSP focuses on building and strengthening local or regional food economy viability and resilience, and this includes pandemic response and recovery. Applicants will work with their partners to catalyze the development of local or regional food systems. Applicants will coordinate efforts within the partnership to set priorities, connect resources and services, and measure progress towards common goals. Partnerships are authorized to:Determine the size and scope of the local or regional food system in which the projects goals, outreach objectives, and eligible activities are to be carried out,Coordinate with AMS to receive technical assistance, andConduct outreach and education for potential participation in the partnership agreement and eligible activities.Partnerships must bring a variety of financial and technical capabilities, demonstrate experience or readiness to work effectively and collaboratively with public and private entities across sectors, and present innovative, sustainable, and measurable approaches to achieving the projects goals. RFSP grant recipients may apply for other LAMP programs on behalf of producers or eligible entities that desire to participate in eligible activities under the partnership agreement.

This grant provides funding for innovative researchers from various scientific fields to develop groundbreaking technologies for recording and manipulating neural activity in the nervous system.

The purpose of this funding opportunity is to support projects which enhance the quality, effectiveness and proven outcomes of nutrition services programs within the aging services network. The Older Americans Act (OAA) provides funding to States and Tribal Organizations to support a broad array of services that enable older adults to remain in their homes and communities and assist family and informal caregivers to care for their loved ones for as long as possible. More information is located here: https://acl.gov/programs/health-wellness/nutrition-services. Through this program, funds will be used to foster the development, testing and replication of innovative service delivery models, policies and partnerships that improve collaboration and coordination between OAA nutrition programs and multi-purpose senior centers. Projects proposed under this grant program must have the potential for broad implementation throughout the aging services network.

Grant Title: Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R01 - Clinical Trial Optional) aims to support research on the neurological and mental health impacts of chronic illnesses triggered by infections, such as post-COVID conditions and myalgic encephalomyelitis, focusing on their underlying mechanisms and potential treatments.

As people harmed by domestic violence, dating violence, sexual assault, and stalking seek expanded options to address the harm they have experienced, communities have continued to strengthen and improve their responses, approaches, and services. One such approach is restorative practices. Restorative practices incorporate an understanding of trauma and are intended to repair and address the harm experienced while providing meaningful accountability for the harm-doer. An effective restorative practices program is completely voluntary for the person harmed, promotes their autonomy, and prioritizes their safety, while promoting meaningful justice, accountability, and community safety. The Violence Against Women Act Reauthorization Act of 2022, 34 U.S.C. 12514, authorizes funding to eligible entities to develop and implement a program, or to assess best practices for: 1) restorative practices to prevent or address domestic violence, dating violence, sexual assault, or stalking; 2) training by eligible entities, or for eligible entities, courts or prosecutors, on restorative practices and program implementation; and 3) evaluations of a restorative practice, as defined within the statute. Accordingly, OVW is launching the Restorative Practices Pilot Program in three (3) phases: 1) Training and Technical Assistance; 2) Evaluation; and 3) Pilot Sites. Phase 1: Training and Technical Assistance OVW issued the FY 2023 Restorative Practices Technical Assistance Pilot Program Call for Concept Papers in March 2023 to identify organizations with the requisite experience and capacity to provide Training and Technical Assistance (TTA) to recipients, subrecipients, and potential recipients and subrecipients of this program. Following an intensive review of responses to the Call for Concept Papers, OVW invited five entities to submit full applications. OVW issued awards to three of those applicants in March 2024 for five-year TTA projects that will run from April 2024 through March 2029 and will involve a planning phase. In addition to providing TTA to the pilot sites, the TTA providers will participate in evaluation efforts funded through the FY 2024 Restorative Practices Pilot Program Evaluation Solicitation. The TTA providers are funded under a separate funding announcement. This solicitation is exclusively intended to fund pilot sites of the Restorative Practices Pilot Sites Program. Phase 2: Evaluation In March 2024, OVW released the Restorative Practices Pilot Program Evaluation Solicitation to invite applications to conduct research and evaluation on restorative practices in collaboration with TTA providers and pilot sites. While pilot sites funded through this Restorative Practices Pilot Sites Program Solicitation will be required to provide funding for and designate an on-site Evaluation Liaison to work with evaluator(s) and participate in the community-tailored evaluation, the comprehensive evaluation will be funded under that separate funding announcement. This solicitation is exclusively intended to fund pilot sites of the Restorative Practices Pilot Sites Program. Phase 3: Pilot Sites (this solicitation) This Restorative Practices Pilot Sites Program is a 60-month funding opportunity seeking to support, strengthen, enhance, and expand existing restorative practice programs that prevent or address domestic violence, dating violence, sexual assault, or stalking, in accordance with the restorative practices definition at 34 U.S.C. 12514(a)(3), and build evidence for victim-centered, trauma-informed, and culturally responsive restorative practices addressing these harms. OVW will award cooperative agreements to eligible entities that form a partnership of two or more entities that have (1) a demonstrated history of comprehensive training and experience in working with victims of domestic violence, dating violence, sexual assault, or stalking; and (2) demonstrated experience in implementing restorative practices. OVW is interested in supporting communities to enhance or expand current efforts, including an evaluation of the intersection of domestic violence, dating violence, sexual assault, stalking and restorative practices. In addition, OVW seeks to fund a range of pilot sites, including sites in various geographic locations with different demographic characteristics; culturally specific, and/or underserved populations; and different VAWA subject areas to be addressed (i.e., domestic violence, dating violence, sexual assault, and/or stalking). OVW is interested in supporting projects that implement a diverse range of restorative practices, including projects that may have a connection to the criminal justice system, as long as the program is not housed within or administered by a court, prosecutors office, law enforcement agency, or any other component of the civil or criminal justice system. Recipients under this program will receive TTA for the duration of their awards that is tailored to the recipients distinct approach to restorative practices in domestic violence, dating violence, sexual assault, and stalking cases. Recipients will be required to collaborate with the evaluator(s) to help develop an understanding of establishing, implementing, and using restorative practices to redress the harm caused by domestic violence, dating violence, sexual assault, and stalking. The terms used throughout this solicitation may vary from people harmed, people who caused harm, harm-doers, victim, survivor, and offender, which reflects terminology used by practitioners and the statutory language that authorizes this program, 34 U.S.C. 12514.

This funding opportunity supports research into the biology and mechanisms of bladder cancer, encouraging multidisciplinary teams to explore both normal bladder functions and cancer processes using clinical specimens.

This funding opportunity provides financial support to nonprofit organizations and local governments to create transitional housing with intensive services for Veterans experiencing or at risk of homelessness, helping them move into permanent housing.

The OIA Technical Assistance Program 2025 provides funding for short-term projects that address immediate needs in U.S. insular areas, focusing on priorities like disaster response, climate change adaptation, and economic development, with awards ranging from $0 to $400,000.

To obtain a copy of the Funding Opportunity Announcement (FOA) please go to the ARPA-E website at https://arpa-e-foa.energy.gov. To apply to this FOA, Applicants must register with and submit application materials through ARPA-E eXCHANGE (https://arpa-e-foa.energy.gov/Registration.aspx). For detailed guidance on using ARPA-E eXCHANGE, please refer to the ARPA-E eXCHANGE User Guide (https://arpa-e-foa.energy.gov/Manuals.aspx). ARPA-E will not review or consider concept papers submitted through other means. For problems with ARPA-E eXCHANGE, email [email protected] (with FOA name and number in the subject line). Questions about this FOA? Check the Frequently Asked Questions available at http://arpa-e.energy.gov/faq. For questions that have not already been answered, email [email protected]. Agency Overview: The Advanced Research Projects Agency Energy (ARPA-E), an organization within the Department of Energy (DOE), is chartered by Congress in the America COMPETES Act of 2007 (P.L. 110-69), as amended by the America COMPETES Reauthorization Act of 2010 (P.L. 111-358), as further amended by the Energy Act of 2020 (P.L. 116-260) to: (A) to enhance the economic and energy security of the United States through the development of energy technologies that (i) reduce imports of energy from foreign sources; (ii) reduce energy-related emissions, including greenhouse gases; (iii) improve the energy efficiency of all economic sectors; (iv) provide transformative solutions to improve the management, clean-up, and disposal of radioactive waste and spent nuclear fuel; and (v) improve the resilience, reliability, and security of infrastructure to produce, deliver, and store energy; and (B) to ensure that the United States maintains a technological lead in developing and deploying advanced energy technologies. ARPA-E issues this Funding Opportunity Announcement (FOA) under its authorizing statute codified at 42 U.S.C. 16538. The FOA and any awards made under this FOA are subject to 2 C.F.R. Part 200 as supplemented by 2 C.F.R. Part 910. ARPA-E funds research on and the development of transformative science and technology solutions to address the energy and environmental missions of the Department. The agency focuses on technologies that can be meaningfully advanced with a modest investment over a defined period of time in order to catalyze the translation from scientific discovery to early-stage technology. For the latest news and information about ARPA-E, its programs and the research projects currently supported, see: http://arpa-e.energy.gov/. ARPA-E funds transformational research. Existing energy technologies generally progress on established learning curves where refinements to a technology and the economies of scale that accrue as manufacturing and distribution develop drive down the cost/performance metric in a gradual fashion. This continual improvement of a technology is important to its increased commercial deployment and is appropriately the focus of the private sector or the applied technology offices within DOE. By contrast, ARPA-E supports transformative research that has the potential to create fundamentally new learning curves. ARPA-E technology projects typically start with cost/performance estimates well above the level of an incumbent technology. Given the high risk inherent in these projects, many will fail to progress, but some may succeed in generating a new learning curve with a projected cost/performance metric that is significantly lower than that of the incumbent technology. ARPA-E funds technology with the potential to be disruptive in the marketplace. The mere creation of a new learning curve does not ensure market penetration. Rather, the ultimate value of a technology is determined by the marketplace, and impactful technologies ultimately become disruptive that is, they are widely adopted and displace existing technologies from the marketplace or create entirely new markets. ARPA-E understands that definitive proof of market disruption takes time, particularly for energy technologies. Therefore, ARPA-E funds the development of technologies that, if technically successful, have clear disruptive potential, e.g., by demonstrating capability for manufacturing at competitive cost and deployment at scale. ARPA-E funds applied research and development. The Office of Management and Budget defines applied research as an original investigation undertaken in order to acquire new knowledgedirected primarily towards a specific practical aim or objective and defines experimental development as creative and systematic work, drawing on knowledge gained from research and practical experience, which is directed at producing new products or processes or improving existing products or processes. (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy (http://fossil.energy.gov/), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity Delivery and Energy Reliability (http://energy.gov/oe/office-electricity-delivery-and-energy-reliability). Applicants interested in receiving financial assistance for basic research (defined by the Office of Management and Budget as experimental or theoretical work undertaken primarily to acquire new knowledge of the underlying foundations of phenomena and observable facts) should contact the DOEs Office of Science (http://science.energy.gov/). Office of Science national scientific user facilities (http://science.energy.gov/user-facilities/) are open to all researchers, including ARPA-E Applicants and awardees. These facilities provide advanced tools of modern science including accelerators, colliders, supercomputers, light sources and neutron sources, as well as facilities for studying the nanoworld, the environment, and the atmosphere. Projects focused on early-stage R for the improvement of technology along defined roadmaps may be more appropriate for support through the DOE applied energy offices including: the Office of Energy Efficiency and Renewable Energy (http://www.eere.energy.gov/), the Office of Fossil Energy (http://fossil.energy.gov/), the Office of Nuclear Energy (http://www.energy.gov/ne/office-nuclear-energy), and the Office of Electricity Delivery and Energy Reliability (http://energy.gov/oe/office-electricity-delivery-and-energy-reliability). Program Overview: The Creating Hardened And Durable fusion first Wall Incorporating Centralized Knowledge (CHADWICK) program will pursue discovery and testing of novel, first-wall materials that will maintain design performance over the target 40-year design lifetime of a fusion power plant. In most fusion power systems, the fusion reactions are physically contained by the first wall. The first wall bears the mechanical load and protects the components from the extreme heat and highly energetic charged and neutral particles. The safety and structural performance of the first wall are compromised over time by significant exposure to high-energy (;gt;1 million electron volts (MeV)) neutrons and heat flux as much as 10 megawatts per square meter (MW/m2)). As fusion energy advances towards commercial deployment, the lifetime and maintainability of first-wall materials will become a major challenge for the commercial viability of fusion power plants with high neutron flux. Thermal effects on materials are relatively well understood. However, the combination of heat plus an intense neutron environment can generate many nonlinear effects that are difficult to predict. Radiation most commonly damages a material by driving atomic displacements and the transmuting of isotopes within the material structure. Some transmutation events encourage the development of activation product gasses, such as hydrogen and helium, which encourage wall swelling. The combination of stresses caused by atomic dislocations, swelling, and thermal contraction and expansion drive material hardening and embrittlement, ultimately promoting premature cracking and failure. The most common descriptor for radiation damage is displacements per atom (dpa). These displacements can cause irradiation embrittlement leading to the loss of ductility in a material after exposure to radiation. Fusion power plant first-wall materials are anticipated to experience ;gt;50 dpa over the desired 40-year operational period. Radiation damage has been observed to harden and embrittle first-wall materials at levels as low as 5 dpa. The goal of the CHADWICK program is the discovery, development, and production of new materials that can maintain the following metrics in a fusion first-wall environment: Room temperature ductility after 50 dpa of irradiation damage and helium generation; Sufficiently high thermal conductivity to remove up to 10 MW/m2 of heat; Activation below 10,000 Sieverts per hour (Sv/hr) to enable remote handling; Swelling below 1% to maintain dimensional stability; and Tritium retention and plasma erosion lower than current state-of-the-art (SoA) materials. SoA materials under consideration for fusion first-wall applications are currently limited to reduced activation ferritic martensitic (RAFM) steels and tungsten.7 Both materials suffer from irradiation and helium embrittlement issues that make fusion power plants prohibitively expensive to qualify and operate. New materials that are highly resistant or functionally immune to irradiation embrittlement up to 50 dpa can increase the lifetime of the first wall by a factor of 10. These materials are envisioned to be essential to the deployment of sustained and economical fusion energy. To view the FOA in its entirety, please visit https://arpa-e-foa.energy.gov.

This funding opportunity provides financial support to local, state, tribal, and territorial law enforcement agencies to develop and implement innovative community policing strategies that enhance public safety and community engagement.

This funding opportunity provides financial support for conservation projects aimed at protecting candidate and at-risk species in the U.S., targeting a wide range of eligible applicants including governments, non-profits, and individuals.

The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and protected time (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Although all of the participating NIH Institutes and Centers (ICs) use this support mechanism to support career development experiences that lead to research independence, some ICs use the K01 award for individuals who propose to train in a new field or for individuals who have had a hiatus in their research career because of illness or pressing family circumstances. Other ICs offer separate K01 FOAs intended to increase research workforce diversity.

This funding opportunity provides financial support to the City of Belvidere, Illinois, for essential improvements to its rail infrastructure, enhancing safety and efficiency in freight and passenger rail services.

This funding opportunity supports innovative, early-stage research involving human participants to advance biomedical and clinical science, targeting a wide range of eligible applicants including universities, nonprofits, and small businesses.

This grant provides funding to support postdoctoral researchers from diverse backgrounds as they transition into independent faculty positions in biomedical research.

The purpose of this research is to systematically evaluate the diastereomeric composition of LEQVIO (Inclisiran), an FDA-approved, N-acetyl galactosamine (GalNAc)-conjugated siRNA drug, and to understand the biological/pharmacological activity of each diastereomer in LEQVIO through stereo chemically controlled synthesis and biological activity assessment using in vitro and animal models. The proposed studies will focus on 1) synthesis of each diastereomer of LEQVIO (Inclisiran) in stereo chemically pure form; 2) assessment of the biological activity of each stereo chemically pure diastereomer in inhibiting PCSK9 activity using in vitro assays and in a transgenic mouse model; 3) development of analytical methods to identify and characterize the stereochemical structure of each diastereomer in LEQVIO; and 4) assessment of the individual contribution of each diastereomer to the overall pharmacological activity of LEQVIO. Tools developed in this research can also be applied to other similar GalNAc-conjugated siRNAs specifically, and other siRNAs in general. Knowledge gained from this research will also contribute to the sameness evaluation of generic siRNAs, and to the quality control of oligonucleotide drugs.

OJP is committed to advancing work that promotes civil rights and racial equity, increases access to justice, supports crime victims and individuals impacted by the justice system, strengthens community safety and protects the public from crime and evolving threats, and builds trust between law enforcement and the community. With this solicitation, BJA seeks to provides funding to states and units of local government with existing crime laboratories that conduct DNA analysis to solve crimes and protect public safety by maximizing the effective utilization of DNA technology to process DNA samples for entry into the Combined DNA Index System (CODIS).

This funding opportunity provides financial support to organizations that develop and expand telehealth programs, enabling pediatric primary care providers to better address the mental health needs of children and adolescents, particularly in underserved areas.