Grants for Nonprofits - Federal

This funding opportunity provides financial support to national hotlines that assist crime victims by enhancing their crisis intervention and referral services across the United States.

The purpose of this initiative is to: 1.Support mining of SCORCH data to identify cell types, transcripts, enhancers, or transcriptional networks that play a role in HIV/ART or SUD molecular responses 2.Support functional validation studies (e.g. epigenomic or transcriptomic manipulation, high throughput secondary screening, etc.) to confirm or deny a biological role for data-mined cell types, transcripts, enhancers, or transcriptional networks in HIV/ART or SUD molecular responses 3.Provide foundational knowledge for understanding SUD and/or HIV/ART molecular mechanisms and to generate validated targets that could serve as a foundation for new SUD or HIV therapeutics (including NeuroHIV cognitive phenotypes)

This funding opportunity is designed to empower emerging leaders in the space sector across the Middle East and North Africa by providing training and resources to enhance collaboration with the United States in space policy and commerce.

This funding opportunity supports innovative research to measure brain changes over time in people of all ages, including those with cognitive or emotional challenges, to better understand brain development and aging.

This funding opportunity supports partnerships between institutions serving underserved populations and cancer research centers to improve cancer research, education, and outreach initiatives aimed at reducing health disparities.

This funding opportunity supports researchers and institutions in validating high-quality biomarkers and assays for cancer detection, diagnosis, and treatment monitoring, facilitating their integration into clinical studies.

Priority Program Areas: A successful proposal will include a robust calendar of activities through serial programming spanning at least two months and directly address at least one of the three key programming areas: Digital Policy, STEM Education and Workforce Development: Programming to expand understanding of emerging technologies and digital policy challenges such as cybersecurity, Intellectual Property Rights, artificial intelligence, fintech, and quantum computing, as well as initiatives to expand technical and soft skills through participatory and interactive workshops on STEM fields, digital trade, digital arts, gaming, and related business practices for online activities for SMEs and/or use of the existing makerspaces at the American Centers. Climate Solutions, Health Security and Sustainability: Programming to achieve measurable goals to improve environmental protection and preservation, climate change adaptation, pollution reduction, renewable energy, climate-smart agriculture, transboundary water challenges, clean energy, and health security and public health preparedness. Information Literacy and Research Skills: Workshops to build critical thinking skills to find, evaluate, organize, use, and communicate information in all its various formats, including through the use of data, digital media, and AI, and develop audiences ability to conduct research and evaluate and use information responsibly and ethically using American Spaces databases and open education resources.

This funding opportunity supports experienced laboratory scientists engaged in cancer research within NCI-funded projects, providing salary support and travel funds to enhance their contributions without requiring them to become independent investigators.

This funding opportunity provides financial support for early-career researchers in genomics to advance innovative projects that contribute to the field and promote diversity within the research community.

This funding opportunity provides financial support to organizations that can deliver safe, high-quality residential care and services for unaccompanied minors without legal immigration status in the United States.

This grant provides funding for interdisciplinary research teams from various institutions to tackle significant biological questions and promote diversity in science education and outreach.

The NSF Engineering (ENG) Directorate has launched a multi-year initiative, theProfessional Formation of Engineers, to create and support an innovative and inclusive engineering profession for the 21stcentury. Professional Formation of Engineers (PFE) refers to the formal and informal processes and value systems by which people become engineers. It also includes the ethical responsibility of practicing engineers to sustain and grow the profession in order to improve quality of life for all peoples. The engineering profession must be responsive to national priorities, grand challenges, and dynamic workforce needs; it must be equally open and accessible to all. Professional Formation of Engineers includes, but is not limited, to: Introductions to the profession at any age; Development of deep technical and professional skills, knowledge, and abilities in both formal and informal settings/domains; Development of outlooks, perspectives, ways of thinking, knowing, and doing; Development of identity as an engineer and its intersection with other identities; and Acculturation to the profession, its standards, and norms. The goal of the Research in the Formation of Engineers (RFE) program is to advance our understanding of professional formation. It seeks both to deepen our fundamental understanding of the underlying processes and mechanisms that support professional formation and to demonstrate how professional formation is or can be accomplished. Ultimately RFE aims to transform the engineer-formation system, and thus the impact of proposed projects on this system must be described. Principal Investigators (PIs) should provide a roadmap detailing how they envision the proposed research will eventually broadly impact practice within the engineer-formation system, even if these activities are not within the scope of the submitted proposal. In order to accomplish its goals, RFE welcomes proposals in two categories: Research Projects, and Design and Development Projects. Research Projects address fundamental questions of professional formation, while Design and Development Projects provide new approaches to achieving professional formation. Additional details are provided below. Projects in both categories should address the iterative cycle in which research questions that advance understanding are informed by practice and the results of research are, in turn, translated into practice. In other words, proposals should explain how the research results will travel, translate, transfer, or scale. Successful projects identify specific target audiences, effective communication channels, and novel partnerships to ensure effective propagation and scaling. Proposal titles should begin with either Research: or Design and Development: as appropriate. Research Projects Research proposals are particularly welcome in the following areas: Research that addresses lifelong learning by the engineering workforce. Research on the impact of engineering education research. Proposals addressing this topic could investigate questions such as: How can we measure the impacts of engineering education research? What are effective strategies for scaling reforms? How can we translate knowledge from research to practice? What are the roles of technologies, networks and communities in achieving impact? RFE does not support efficacy, effectiveness, or scale-up studies for specific interventions. Research that addresses culture change in engineering education. Included in this topic are investigations of normative cultures of engineering at any level in the engineering education ecosystem and how these cultures may disadvantage certain groups. Research that addresses engineering formation at the two-year college and graduate education levels in both formal and informal settings. Research that investigates engineering in P?12 settings. Research in this area could include understanding of approaches to engineering in P?12, how to develop engineering ways of thinking, or the relationship between practices within the sciences and mathematics and engineering thinking. Research on the transitions between education levels, e.g., from high school to two-year college, high school to four-year college/university, two-year college to four-year college/university, undergraduate to graduate school, education settings to the workforce or professoriate, etc. Research that addresses the relationship between engineering and the public. Proposals addressing this topic could consider the social impact of engineering solutions, citizen engineering, education of an informed public, etc. Research that develops or adapts novel methodologies and frameworks appropriate for studying the professional formation of engineers, and especially minoritized, marginalized, or underserved populations. Research that addresses ways in which new technologies (such as artificial intelligence and machine learning) are changing engineering education. Proposals submitted to the Research Projects category should have clear research questions informed by an appropriate theoretical framework and a research design that includes sampling, data collection, and data analysis methods. This category will not support proposals that seek funding primarily to develop tools, curriculum, or laboratories, or that seek to implement classroom innovations that have already been shown to be effective in engineering. The program will evaluate the value of proposals by considering the impact and the cost. Research track projects that are small, exploratory, or speculative are especially encouraged. Larger Research track projects should have a correspondingly larger impact. Design and Development Projects RFE supports Design and Development projects (see https://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf13126) that seek to develop and test new approaches in the following areas: Graduate education. Transitions between education levels, e.g. high school to two year college, high school to 4 year college/university, two year college to 4 year college/university, undergraduate to graduate school, education settings to the workforce or professoriate, etc. K12, especially approaches to develop engineering thinking, or providing links between engineering, science, and mathematics Proposals in this category should propose the design and development of new approaches that are informed by existing literature and theory. There should be clear objectives and the evaluation plan should be designed to determine if those objectives have been met. Projects cannot be solely demonstration projects, but must add to the engineering education literature to inform future work.

The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.

INL seeks to assist the Kingdom of Morocco, through its Ministry of Justice (MOJ) and General Delegation for Prison Administration and Rehabilitation (DGAPR) in implementing a community corrections/ATI system. Moroccan prisons are regularly overcrowded, due largely to the lack of probation and parole options available to the accused. Those that are available under Moroccan law are rarely implemented. According to some reports, approximately 40% of all detainees in Morocco are held in pretrial detention. INL seeks to address overcrowding and pretrial detention rates by assisting the DGAPR and MOJ in developing a streamlined and effective ATI/community corrections regime within the framework of Moroccos draft ATI law (if implemented). Additionally, the MOJ is actively working on developing a drug diversion program for non-violent offenders, and INL welcomes proposals that include rehabilitation and diversion programs in their work. Implementation of an effective community corrections program that utilizes ATI will improve the capacity of the justice and corrections sectors to provide equitable and efficient access to justice throughout the country. Though Moroccos draft ATI law is expected to be passed in the near future, successful proposals will be designed to not be wholly contingent on the ATI law being passed into law.

Notice of Funding Opportunity Description Background The accumulation of misprocessed and aberrant proteins is a defining characteristic of various neurodegenerative conditions, such as AD and frontotemporal lobar degeneration (FTLD). These atypical proteins may arise from various factors, such as somatic mutations, environmental changes, genomic instability, irregular RNA processing, and proteolytic cleavages, as well as incorrect folding and post-translational modifications. For instance, many recent proteome and transcriptome profiling of AD brains reveals RNA splicing dysfunction and abnormal accumulation of U1 small nuclear ribonucleoprotein (snRNP) and transactive response DNA-binding protein 43 (TDP-43). In AD, U1-70K and its N-terminal 40-KDa fragment (N40K) is one of the most abundant proteins in the insoluble fraction of cell lysates. TDP-43 is an RNA-binding protein. In AD, TDP-43 pathology is observed in approximately 25-50% of cases, particularly in cases with co-morbidities such as Lewy body dementia or hippocampal sclerosis. However, the relationship between U1snRNP/TDP-43 and AD pathology is complex and not fully understood. The disruption of RNA processing is thought to be one possible mechanism to cause the accumulation of misprocessed proteins, which can lead to altered expression of genes involved in AD pathology, including amyloid precursor protein (APP), tau, and synaptic proteins. Understanding the mechanisms underlying the dysregulation of misprocessed proteins in neurodegenerative diseases will be important for developing effective therapies. Approaches that target the production or aggregation of misprocessed proteins, or that promote their clearance or degradation, may be effective in preventing or slowing disease progression. Purpose This NOFO invites innovative research proposals to explore the accumulation of misprocessed proteins in Tauopathies within specific brain regions and cell types. This NOFO encourages collaborative efforts to create advanced single-cell or single-cell type proteogenomic platforms. These platforms aim to shed light on dynamic changes in protein-misfolding responses in neuronal proteomes and their potential biological consequences during aging and the development of AD/ADRD. Research Objectives This NOFO aims to provide a proof-of-principal for a novel strategy to identify misprocessed and aberrant proteins in Tau diseases using the proteogenomic approach. Proteogenomics is an integrated approach that combines proteomics and genomics data. In proteogenomics, genomic and transcriptomic experiments are more closely integrated to identify potential protein coding and non-coding regions in the genome. These regions are then validated using mass spectrometry-based proteomics. Proteogenomics has emerged as a powerful tool for investigating the role of protein homeostasis in AD pathogenesis, especially in the context of mis-translated and mis-repaired proteins. However, relying solely on misprocessed protein levels to draw conclusions about biological processes is unlikely to be reliable. Therefore, an intermediate layer of functional validation is essential to transform proteogeomic data into meaningful biological information. As a result, the objective of this NOFO is not only to confirm changes in protein abundance using other methods, but also to assess the biological effects of those changes in some model systems, especially in the area of tauopathies, to ensure high interlaboratory reproducibility. Using the proteogenomics approach, this NOFO aims to accomplish the following: Create a comprehensive database of misprocessed and aberrant proteins in selected mouse models of human Tau diseases. Cross-validate the presence of misprocessed and aberrant proteins in human AD/ADRD brains. Identify new molecular pathways and novel misprocessed protein-protein interaction networks that are not currently in most datasets. Define novel mechanisms through which misprocessed and aberrant proteins influence the onset and progression of neurodegeneration in tauopathies. Identify disease specific therapeutic targets in neurodegenerative diseases. It is expected that applications responding to this initiative will use the latest cell-type-specific labeling and proteogenomic techniques with suitable model systems to understand the etiology of tauopathies in aging and AD.

The Public Diplomacy Section of the U.S. Embassy in Madrid and U.S. Consulate General in Barcelona (known collectively as PD Spain) of the U.S. Department of State announces an open competition for organizations to submit proposals to design, manage, and implement Defensa y Yo 5.0, a program promoting security and defense issues among Spanish and Andorran public university students. In 2021, working with a local partner organization, Mission Spain established "Defensa y Yo" (DyY) a program promoting security and defense issues among Spanish youth. The program includes three elements: 1) Lectures by U.S. experts in select Spanish public universities on a variety of topics related to security and defense. 2) Attendees can then participate in a competition where they submit a project on one of the topics covered in the lecture series. 3) A winner is selected from each university, with winning students traveling to Brussels to visit NATO headquarters and other security and defense institutions. For this fifth edition of the Defensa y Yo program, Mission Spain welcomes creative proposals to continue the program in sixteen selected Spanish public universities, strengthen the relationships with both the university administrators and professors, and engage the network of participants from the four previous editions. Program Objectives: Objective 1: Spanish public university students gain knowledge and tools to discuss and share accurate information on security and defense issues with their peers and become better informed future leaders. Objective 2: Strong relationships are formed with both the university administrators and professors. Objective 3: Mentorship relationships are formed between participating students of all four editions of DyY and the alumni association GEOSEDE. Recipient Responsibilities: This award will be separated into two parts to include a non-competitive continuation clause based on awardee performance and execution of the program objectives detailed below in part one. Funding for part two of the project is not guaranteed, and the renewal of the award to cover the second part of the project is at the discretion of the Department of State, and will be evaluated based on successful completion of the recipient responsibilities and program objectives. Part One: 1. Develop and implement a program consisting of a series of lectures (in-person or virtual, when necessary) on security and defense themes featuring a U.S. expert (i.e. representatives from academia, civil society, international organizations, think tanks, U.S. government, etc.). These lectures will take place at sixteen selected Spanish public universities - one session per university from February 2025 to May 2025. Ideally, the grantee will invite a total of four speakers, one per month. Each speaker would reach four of the participating universities during the course of one week. These U.S. speakers will be selected by the grantee in collaboration with PD Spain. 2. Prepare program guidelines and other relevant materials for professors of the participating Defensa y Yo universities. 3. Conduct a formal registration of all attendees of the Defensa y Yo sessions at the sixteen participating universities. Design and conduct qualitative and quantitative research pre and post program via survey, focus groups, etc. to measure the programs effect on the participants as well as general trends, mindsets, and knowledge of the target audience on security and defense issues. 4. Maintain and support the existing Defensa y Yo website to convey program information and highlights with featured editorial space on the grantee’s website. 5. Develop and implement a media and social media plan, with a specific emphasis on promoting the program and highlighting program impact in the sixteen universities. The press and social media campaign should be coordinated with the communications departments of the participating universities and PD Spain. 6. Develop a competition for lecture attendees (students) that identifies the best project per University around a chosen theme related to security and defense issues. Pieces should be submitted by the student participants of the Defensa y Yo program who have registered and attended the Defensa y Yo sessions; 7. Develop a transparent review process that involves PD Spain to evaluate competition applicants (one selected candidate from each one of the participating universities) for the exchange program in Brussels. 8. Organize a professional development opportunity for all 16 professors from participating universities to strengthen their network and knowledge in defense-related topics. Coordinate travel logistics, provide necessary documentation, and implement engaging activities. Part Two: 9. Conduct a pre-departure orientation (in-person, in Madrid) for Defensa y Yo Fellows before their departures from the city where their university is located to Madrid and Brussels; 10. Create program materials (both electronic and print) to assist finalists in preparing for their fellowship in Brussels, and answer questions on programmatic issues, including, but not limited to, program responsibilities and expectations, travel, accident and sickness benefits, lodging and meals and incidentals, leadership development, etc.; 11. Arrange and cover via award the cost of all appropriate program-related travel for Defensa y Yo Fellows to participate in a 4-day exchange program in Madrid and Brussels in the fall of 2025, including but not limited to transportation, lodging, and meals and incidental expenses, etc.; 12. Develop and implement a social media plan during the exchange program in Brussels, with a specific emphasis on the student winners participating in the program; 13. Manage financial aspects of the program including timely disbursement of participant meal and incidental stipends, lodging and travel allowances, etc. and promptly report any irregularities in the budget or spending to PD Spain both for participating speakers, participating professors, and selected student winners during their exchange program; 14. Participate in regular program reviews and meetings with PD Spain (in person or by telephone) that provide general updates on program implementation and matters of concern including but not limited to a review of the effectiveness of past activities, progress on anticipated programmatic activities, and issues that may impede the implementation of planned programming; 15. Respond fully and promptly to requests for program or statistical information from PD Spain, including but not limited to providing information through spreadsheets and databases; 16. Ensure compliance with the terms of this NOFO, including but not limited to submitting timely financial and program reports and proper budget oversight. Participants and Audiences: Project should involve at least 500 Spanish public university undergraduate students (18-25) enrolled in International Relations, Law, Journalism, and Business Administration programs at sixteen universities, and a network of professors of all sixteen selected universities. Further Information: Further information and application instructions can be found on the U.S. Embassy Consulate in Spain and Andorra website: https://es.usembassy.gov/grants-programs/ as well as an attachment on this posting. Any questions about the opportunity or the application should be directed to [email protected]. NOTE: This notice is subject to availability of funding.

This funding opportunity provides financial support to nonprofit organizations in Kansas to establish Centers for Independent Living that assist individuals with significant disabilities in achieving greater independence and community participation.

This grant provides funding to organizations for conducting essential studies and analyses to improve the water intake system at a fish hatchery in California, ensuring the sustainability of fish populations and the recovery of endangered salmon species.

The Naval Air Warfare Center Aircraft Division (NAWCAD) is interested in receiving white papers for Research and Development projects which offer potential for advancement and improvement of NAWCAD operations. Research Opportunity Areas of Interest:  Aeromechanics. Areas of research include but are not limited to the following: aerodynamic and flight controls (manned and unmanned), aeromechanics modeling and analysis tools, flight performance, rotorcraft aerodynamics and performance, ship/aircraft aerodynamic interactions, and unmanned aviation and integration including pilot augmentation and automation and UAV autonomous landing flight mechanics.  Artificial Intelligence (AI) / Machine Learning (ML) (Priority). Areas of research include but are not limited to the following: Autonomous system development, testing, evaluation, verification and validation tools, airworthiness and risk quantification/acceptance, collaborative autonomy, complex reasoning, multiagent based operation and decision making, airspace integration including sense and avoid algorithms, deep reinforcement learning, neural networks, and demand forecasting.  Avionics, Sensors & Electronic Warfare: Areas of research include but are not limited to the following: passive/active sensor systems (RF, EO/IR, and acoustic), advanced/alternative precision navigation and timing (PNT), advanced computational/open system architectures, advanced signal and image processing, flight information and control systems, and advanced concepts in electronic warfare systems.  Cyber (Priority). Areas of research may include but are not limited to the following: cyber effects modeling, reverse engineering, behavioral analysis, intrusion, adaptive cybersecurity, simulation and interface research, concolic testing and systems configuration management. Page | 4  Data Science & Visualization. Areas of research include but are not limited to the following: predictive modeling algorithms, complex big-data environments, data access, storage and retrieval, data visualization techniques, risk assessment and uncertainty quantification, and statistical analysis.  Digital Engineering (Priority). Areas of research include but are not limited to the following: advancements in the use of Digital Twin technology and concepts to support predictive maintenance, automated sustainment environment, diagnostics and prognostics, predictive maintenance, digital communication of system requirements using model-based systems engineering (MBSE)/Systems Modeling Language (SysML) views, engineering models and virtual environments to test designs across broader parameters than what live testing permits  Human Systems. Areas of research include but are not limited to the following: human performance assessment and modeling, cognitive performance/workload, human-machine interface/teaming, protective equipment, controls and displays, ergonomics, anthropomorphic measurement, virtual environments, and human factor engineering (social, behavioral, health, and cultural).  Hypersonic Systems (Priority). Areas of research include but are not limited to the following: external and internal high-speed aerodynamic, multi-physic modeling and simulation, hypersonic system testing and evaluation, high temperature and specific strength materials, structures and coatings, guidance, navigation and control and advanced air-breathing propulsion.  Materials and Aircraft Structures. Areas of research include but are not limited to the following: additive manufacturing, corrosion prevention, non-destructive inspection, structural repair and repair processes for metals and ceramics, polymers and composites, analysis and simulation of aircraft structures, structural mechanics, fouling, low observable, high temperature material, low temperature icing resistant and life management of airframes.  Mechanical Systems. Areas of research include but are not limited to the following: fire and ice protection for aviation systems, fuel containment, hydraulic systems, pneumatic systems and landing gear systems analysis.  Power and Propulsion Systems. Areas of research include but are not limited to the following: reliability engineering, fuel systems, prognostics and diagnostics, energy storage/efficiency, air‐breathing engines, fuels and lubricants, electrical power generation, auxiliary power, low observable signature technologies, propulsion life management, and mechanical and drive systems. Page | 5  Quantum (Priority). Areas of research may include but are not limited to the following: secure communication and sensing capabilities, nitrogen vacancy diamond sensing, quantum encryption and quantum computing.  Secure Communications & Networks (Priority): Areas of research include but are not limited to the following: resilient data and communications networks for Command and Control, architecture, analysis and software development, information assurance including blockchain networks and security, platform/system health monitoring, effective data transfer of both communications and video and integration of security end to end in software development, all with consideration for autonomous applications, while performing in dynamic and contested environments.  Support Equipment. Areas of research include but are not limited to the following: launch and recovery equipment, electro‐magnetics, high‐energy generation and control, environmental sensing, prognostics and health monitoring, automatic testing of hardware and software, displays, advanced maintenance technologies, information systems and intelligent agents, and advanced computer and data processing applications.  Test and Evaluation Engineering. Areas of research include but are not limited to the following: telemetry, communications, data links and data acquisition, signature technologies, mission system testing, system of systems testing environments, virtual reality (VR), augmented reality (AR), extended reality (XR), target engineering, airborne threat simulation, integrated battle‐space simulation (Live Virtual Constructive Environments), hardware‐in‐the‐loop testing, flight instrumentation, ground radar analysis, test article configuration, navigation, and identification, manned-unmanned teaming, advance training systems to include instructional techniques and strategies, and game-based training.  Warfare Analysis. Areas of research include but are not limited to the following: operational suitability, signal extraction, clutter reduction, modeling and simulation, maritime effectiveness, vulnerability and capability based assessment, and conceptual aircraft design.

This funding opportunity supports researchers exploring the mechanisms of Treponema pallidum, the bacteria responsible for syphilis, to address the rising rates of sexually transmitted infections and improve understanding of its pathogenesis.