Grants for Nonprofits - Federal

This grant provides funding for research teams to study how early-life social and environmental factors influence brain development and addiction risk using animal models and advanced neuroscience techniques.

This cooperative agreement establishes the Hepatitis C Training and Implementation Center (HC-TIC) Network, which aims to accelerate the integration of hepatitis C prevention, testing, care coordination, and treatment interventions (program implementation) in priority high-impact settings through training and implementation TA. This cooperative agreement will improve and sustain the quality, availability, and reach of hepatitis C prevention and care activities in priority high-impact settings. Protection of public health and safety through the control and prevention of disease, injury, and disability in the U.S. and worldwide with attention to infectious disease, food borne pathogens, environmental health, occupational safety and health, health promotion, injury prevention and educational activities.

This funding opportunity provides financial and technical assistance to partners for projects that restore aquatic connectivity and improve fish passage in rivers, floodplains, and coastal habitats, benefiting ecosystems and local communities.

This funding opportunity provides financial support to collaborations involving state utility commissions, grid operators, and large electricity users to develop innovative solutions for managing increasing electricity demand while keeping costs low for consumers.

This program provides funding to U.S. colleges and universities to develop and enhance their capabilities for translating academic research into practical applications that benefit society and the economy.

With this solicitation, OJJDP seeks to support states implementation of innovative and/or research-based, data-informed policies to improve juvenile justice system outcomes and sustainable strategies for reinvesting resulting costs saved or averted into effective delinquency prevention and intervention programs.Eligibility This solicitation is composed of two grant categories. Applicants must clearly designate the category for which they are applying. Category 1: Juvenile Justice System Reform State governments Category 2: Juvenile Justice System Reform Training and Technical Assistance Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public- and state-controlled institutions of higher education Private institutions of higher education For-profit organizations other than small businesses Small businesses

The Public Diplomacy Section (PD) of the U.S. Embassy in Luxembourg announces an open competition for organizations to submit applications to carry out programs strengthening bilateral ties between the United States and Luxembourg on Engaging Students in English. The U.S. Embassy Luxembourg invites proposals from non-governmental organizations, think tanks, government institutions, academic institutions, and individuals for programs strengthening the bilateral ties between the United States and Luxembourg and Engaging Students in English, including, but not limited to: Programs focused on strengthening specific English language skills or professional English capacity of students, such as public-speaking, debate, theater/drama Programs that enhance and promote the English-teaching profession and community, such as trainings, workshops, conferences, or presentations for English educators in Luxembourg. English-language programs for underprivileged groups including but not limited to patrons of organizations, such as shelters for refugees, women, abuse victims or childrens organizations. Educational programs such as English language camps, academic competitions, international exchanges, conferences, workshops, courses, exhibits, hackathons, online projects, or performances. Projects that share American best practices in English-language education by bringing U.S. experts to engage with students and teachers in Luxembourg. All programs must engage Luxembourg audiences. All programs must include a U.S. element or connection with U.S. experts that will promote increased understanding of U.S. policy and perspectives. Any speaker paid with grant funding must hold U.S. citizenship. Please review the complete NOFO on the Funding Opportunities page on our website: https://lu.usembassy.gov/grants-program/ or in the related documents tab on the announcement on grants.gov to find more information on how to submit a Statement of Interest.

This funding opportunity supports early career scientists in the U.S. who are working on planetary science research, helping them advance their projects and professional development through financial support.

This funding opportunity provides financial support to organizations working to empower Tajik communities in detecting and responding to terrorist recruitment and activities, enhancing regional security in Central Asia.

This funding opportunity supports researchers and organizations developing innovative therapeutic leads for diseases related to diabetes, digestive, and kidney health, focusing on early-stage preclinical validation to advance potential treatments not currently pursued by major pharmaceutical companies.

This funding opportunity provides financial support to non-profit organizations and governmental institutions in Uruguay and the U.S. to implement projects that strengthen economic development, democracy, and security, fostering collaboration between American and Uruguayan entities.

This grant provides funding for early-phase clinical trials aimed at improving treatments for service-connected eye injuries and visual dysfunction in military personnel and veterans.

The National Cancer Institute is offering funding for research projects aimed at validating the effectiveness of various markers and assays in cancer detection, diagnosis, treatment, and prevention, with a focus on developing these into clinical assays and ensuring their performance across multiple laboratories.

This funding opportunity supports researchers in developing innovative, safe, and noninvasive methods to assess the placenta's development and function throughout pregnancy, with the goal of improving maternal and fetal health outcomes.

This grant provides funding for researchers to explore how HIV infection alters immune and metabolic responses, increasing the risk of tuberculosis and hepatitis B in individuals on antiretroviral therapy.

This funding opportunity supports clinical research to explore and validate new non-invasive brain stimulation techniques for treating substance use disorders, targeting a wide range of eligible applicants including universities, nonprofits, and businesses.

Reissue of PA-18-350. The NIMH Exploratory/Developmental Grant program supports exploratory and high-risk research projects that fall within the NIMH mission by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough or to the development of novel techniques, agents, methods, measures, models, or strategies, or to the generation of pilot or feasibility data. The preliminary work from these studies could lead to a major impact on biomedical, behavioral, or clinical mental health research, or on the delivery of mental health care.

This program provides financial and technical support to private landowners and communities for restoring and conserving fish and wildlife habitats on private lands, benefiting endangered species and promoting biodiversity.

The "Coordinating Center for Type 1 Diabetes TrialNet" grant aims to fund the TrialNet Coordinating Center, which conducts research, trials, and studies to prevent the progression of type 1 diabetes and preserve insulin production, while also managing data, samples, and network operations, and promoting diverse perspectives in its work.

This notice of funding opportunity (NOFO) will support projects proposing mechanistic studies that will transform our understanding of polysubstance use in addiction. These hypothesis-based, exploratory projects may investigate mechanisms of polysubstance use at the behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological and/or computational levels. Research on substance use disorders (SUDs) has primarily focused on individual substances although polysubstance use is prevalent. Polysubstance use is the use of more than one addictive substance within a defined interval; the use may be sequential (use of multiple substances on separate occasions), or concurrent/simultaneous. Limiting studies to an individual addictive substance overlooks potential interactions between substances and could influence the translational potential of preclinical research findings. Results from several studies have demonstrated that the use of multiple addictive substances produces pharmacokinetic and behavioral profiles that are distinct from those produced by a single substance. Despite this recognition, little is known about the precise pharmacological mechanisms and interactions that may contribute to such outcomes, or co-morbidities resulting from co-use. There is also a significant lack in our understanding of how the activity of discrete cells, genes, circuits, expression of receptors, ion channels, intrinsic excitability or signaling mechanisms in the reward systems synergize when exposed to distinct classes of drugs simultaneously or sequentially. Even less is known about these mechanisms in brain regions and circuits that underlie negative reinforcement, or how neurotransmitters, neuromodulators or stress interact within these circuits to contribute to the behavioral and pharmacological profiles observed following polysubstance use. In addition, there is a need for behavioral models of polysubstance use that have translational potential. Research Objectives: The National Institute on Drug Abuse (NIDA) seeks to stimulate innovative research that will transform our understanding of the basic mechanisms that underlie polysubstance use in addiction. These studies will investigate novel neurobiological, pharmacological and/or behavioral mechanisms underlying the biobehavioral outcomes of polysubstance use. Research areas and questions of programmatic interest include, but are not limited to: Identification and/or characterization of molecules, genes, cells (including non-neuronal cells), neural pathways, circuits, receptors, ion channels, intrinsic excitability, pharmacological and signaling mechanisms mediating the effects of polysubstance use. Mechanisms underlying the association of early adolescent polysubstance use with SUD’s in adulthood. Sex differences in the development and trajectory of polysubstance use. What are the roles of organizational and activational effects of sex steroids on discrete brain regions and neural circuits, and how is this altered with exposure to polysubstance use? What are the developmental determinants? Are there developmental windows during which polysubstance use would be facilitated? What are the pharmacologic, pharmacokinetic and pharmacodynamic interactions that can impact toxicity, or the SUD trajectory? How do environmental factors interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? How does stress interact with brain circuits to influence the development and trajectory of SUDs involving polysubstance use? Are there neurobehavioral risk phenotypes for progression to polysubstance use? What are the neurocognitive and neurobehavioral changes that occur through experience with different patterns of polysubstance use? Applications Not Responsive to this Notice of Funding Opportunity (NOFO) The following types of studies are not responsive to this NOFO and will not be reviewed: The major goal of the project is not targeted at delineating the basic mechanisms underlying polysubstance use in addiction. Projects limited exclusively to the phenomenology of polysubstance use, consequences of polysubstance use, or those focused exclusively on the development of tools or animal models. Projects that do not focus on combinations of two or more addictive substances with well-justified translational and public health relevance. Projects that do not include a psychostimulant, opioid, or cannabinoid in the polysubstance combination. Alcohol may be included in the polysubstance combination. Research that does not pertain to at least one of the stages of the substance use trajectory, including, but not limited to initiation, escalation, withdrawal and/or relapse. Other application considerations: Collaborative research teams to foster the sharing of conceptual and/or technical expertise are strongly encouraged. Applicants using animal models are encouraged to use models reflective of chronic and voluntary drug intake. Preliminary data are not required but may be included if available. In the absence of preliminary data, a strong premise should be provided for testing a novel hypothesis based upon the scientific literature as well as evidence of the team’s ability to carry out the proposed studies through published or technical preliminary data.