Grants for Nonprofits - Federal

This NOFO invites applications for the Nathan Shock Centers of Excellence in Basic Biology of Aging (NSC). These Center grants will provide funding for leadership, training, research, and outreach activities that will increase and disseminate scientific knowledge in areas supported by the NIA's Division of Aging Biology. The NSC were created in 1995 in honor of Nathan Shock, founding head of the NIH Gerontology Research Center. The NSC provide, both within and beyond their institutions, intellectual leadership and innovation; training; pertinent service cores focused on the needs of the field; and opportunities for research career development. They each collaborate substantially with other NSC and other NIA-funded Centers through the Research Centers Collaborative Network (RCCN). The NSC awards are intended for institutions committed to research on the basic biology of aging, The awards will facilitate further sustained progress on basic research on aging biology, either overall or on a key area within the field. Research Objectives To achieve the objectives above, applicants may propose a sustained research program focused on aging biology as a general term, or by identifying a well-defined and focused area within the field. If a focused research area is selected, service core activities (see below) should be consistent with that selection. Reviewers will be instructed to accept either approach (general or focused) as responsive to this NOFO. It is crucial to the design of each NSC that applicants specify the goals to be achieved within the five-year award period, to provide a plan to reach these goals, and to outline a method to evaluate progress toward these goals. The selection of core activities (see below) should follow from these considerations. Applications in response to this NOFO must include the following: Provide intellectual leadership in biology of aging research, serving as a resource for experimental design and guidance on the appropriate uses and limitations of aging metrics. Support multidisciplinary and translational research. Provide access to technologies through the cores. Develop technology (in the cores) for emerging areas of research in biology of aging. Leverage local institutional resources. Collaborate with other NSC and The Nathan Shock Centers Coordinating Center (NSC3) on multi-center research education, mentorship, and outreach programs. Interface with other NSC, the NSC3, and other NIH funded centers directly (as appropriate) or through the NIA-supported RCCN. To support these goals, each application must include the following: A core to support administrative functions. This core will manage outreach activities including courses, lectures and symposia – if such activities are proposed. This core will also be responsible for advertising the activities of the NSC, through development of a functional website, and participation in a common Data Coordination Center (see below). The leader of this core must be a PD/PI. A research development core to support pilot/feasibility projects, as well as provide support for investigators entering the field of biology of aging research. At least two research core activities uniquely focused on issues of interest to the biology of aging. These are further discussed below. Support for Research Each NSC may select an area of research focus from a broad range of topics, including, but not limited to, the following examples: Drivers of aging (often considered hallmarks); Metrics of aging, including biomarkers, clocks, computer-based modeling, imaging, etc.; Life course approaches to aging biology; Species-differences and similarities in aging; Medicinal chemistry for development of gerotherapeutics and geroprotective pharmacological interventions; Development and dissemination of new technologies to retain age-of-donor traits for in vitro systems; Facilitation of translation to clinical research; and Support for biology of aging research in IDeA states. Support for Outreach and Education Each NSC should place special emphasis on career development, engaging the public and providing education around the topic of aging biology, including, but not limited to the following examples: Mini-sabbaticals for mid-career and senior investigators (emphasizing new-to-aging research); Community engagement – inform about biology of aging and opportunities for citizen science; Webinars; and Symposia. Applicants must provide plans for the following elements: Leadership succession; Fostering an inclusive and accessible research training environment; and Evaluation: Applications must include a clear description of their objectives and a plan for evaluating the NSC, including all activities supported by the NSC, in line with the broader NSC program goals. The application must specify baseline metrics of NSC activities (e.g., numbers and characteristics of workshop participants, scientific dissemination, databases, networking opportunities with other funders, users of resources, etc.), as well as clearly defined milestones with metrics to gauge the short- or long-term success of the NSC in achieving its objectives. Wherever appropriate, applicants are encouraged to obtain feedback from participants to help identify weaknesses and to provide suggestions for improvements. The NSC evaluation plan should focus on the activities of the NSC, not the entire NSC program. NIH will evaluate the entire NSC program and NSC in five years, including the role of the NSC in fostering the success of the program. Based on the review, NIA will evaluate the effectiveness of the program, and determine whether to (a) continue the program as currently configured, (b) continue the program with modifications, or (c) discontinue the program after sunset and review period. Pre-Application Webinar A webinar is planned to provide prospective applicants the opportunity to understand and ask questions on the scientific scope of this NOFO and technical details for applying. The webinar will be open to all prospective applicants. Participation in the webinar is not a prerequisite to applying to this NOFO, but prospective applicants will need to register in order to participate. Prospective applicants are also encouraged to submit their questions in advance of the webinar; further details on where to submit the questions will be provided once the webinar has been scheduled. Please refer to the registration page for further details on the pre-application webinar, including the time and date and registration information.

This funding opportunity supports not-for-profit organizations, educational institutions, and individuals in Fiji, Kiribati, Tuvalu, and Nauru to develop programs that strengthen ties with the United States through cultural exchange, economic development, and educational initiatives.

This grant provides funding for research and projects that develop climate change predictions and analyses to help industries adapt to and mitigate the impacts of climate-related challenges through 2050.

The "Addressing Barriers to Healthcare Transitions for Survivors of Childhood and Adolescent Cancers" grant aims to fund research for developing and testing interventions that improve the transition from pediatric to adult healthcare for childhood and adolescent cancer survivors, with the goal of establishing best practices for their long-term care.

This funding opportunity provides financial support for small clinical trials focused on preventing and treating diseases related to diabetes, digestive, kidney, and urologic health, particularly targeting underserved populations to improve health outcomes.

This grant provides funding to educational organizations and institutions to develop and implement innovative programs that enhance early learning and improve educational outcomes for students in elementary and secondary education.

This grant provides funding for innovative technologies that improve the Navy and Marine Corps' electronic warfare and surveillance capabilities, targeting researchers and companies developing advanced signal processing, countermeasures, and ISR systems.

The FY 2025 Future Leaders Exchange (FLEX) Program Placement Components grant aims to foster mutual understanding and enhance U.S. relations with various European and Eurasian countries by enabling high school students from these regions to live, study, and develop leadership skills in the U.S., while also sharing their own cultures with their host communities.

This funding opportunity provides financial support for organizations in Nigeria to preserve and protect cultural heritage sites, collections, and expressions that are important to local communities.

The purpose of this SAMHSA program is to create a National Center for Mental Health Dissemination, Implementation, and Sustainment (MHDIS) to build the capacity of CMHS grant recipients, as well as organizations that oversee or directly provide mental health services to improve the implementation of evidence-based change management processes that guide mental health services. This will be accomplished by establishing five bi-regional Mental Health Technical Assistance Centers (MTACs) that provide localized, targeted and intensive technical assistance (TA) to CMHS grant recipients and other mental health providers.

Public Diplomacy Section in Windhoek invites proposals for programs that strengthen cultural ties between the United States and Namibia through cultural and exchange programming that highlights shared values and promotes bilateral cooperation. All programs must include an American cultural element, or connection with American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. policy and perspectives.Directly support U.S. treaty or bilateral agreement obligations.Directly support U.S. policies, strategies, and objectives in a country as stated in the Integrated Country Strategy (ICS) (ICS is the four-year strategy that articulates the U.S. priorities in a given country and is led by the Chief of Mission.) These priorities are Empowering an Inclusive, Rules-Based Democracy, Catalyzing a Resilient, Sustainable Economy and Cultivating Equitable Access to Service to help Unleash Namibias Human Resources.Support disaster risk reduction for cultural heritage in disaster-prone areas, or post-disaster cultural heritage recovery.Complement the Cultural Heritage Center in the Bureau of Educational and Cultural Affairs (ECA) or Public Diplomacy programs.

The Office of English Language Programs (ECA/A/L) of the Bureau of Educational and Cultural Affairs announces an open competition for the FY 2024 Online Professional English Network (OPEN) Program, which offers foreign English teaching professionals and language learners the opportunity for professional development through high-quality, accessible, and openly licensed virtual resources, including online English language teacher development courses, online English language learning courses, virtual exchanges, webinars, an alumni community of practice (CoP), multiple social media channels, and other types of engaging and innovative online learning. In cooperation with ECA/A/L, the award recipient will manage the selection, development, and delivery of appropriate online TESOL (Teaching English to Speakers of Other Languages) learning courses which will be offered to English language educators or learners on an easily accessible online learning management system (LMS). Courses, webinars, and other virtual programming may be offered globally, regionally, or to specific countries at the request of U.S. embassies. Courses and exchanges are developed by U.S. academic institutions, educational NGOs, or TESOL professional associations, while webinars and other social media programming are developed by U.S.-based TESOL professionals. All content produced for this program should be accessible according to Section 508 compliance standards, openly licensed with a Creative Commons Attribution (CC BY) License, and follow best practices for diversity, equity, inclusion, and accessibility (DEIA). ECA/A/L anticipates an unlimited number of English language professionals, educators, and learners will benefit from the openly licensed virtual programming, webinars, massive open online courses (MOOCs), and content developed under this award. U.S. public and private non-profit organizations meeting the provisions described in Internal Revenue Code, Section 26 U.S.C 501 (c) (3) may submit proposals to administer and manage the FY 2024 OPEN Program. It is ECA/A/Ls intent to award one cooperative agreement in the amount of $6,000,000, pending the availability of FY 2024 funds, to an applicant that has the ability to achieve these objectives and provide the necessary infrastructure and experience. ECA/A/L reserves the right to reduce, revise, or increase proposal budgets and participant numbers in accordance with the needs of the program and the availability of funds. Please see the full announcement for additional information.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for identification of small molecules that function to elucidate the biology of disease as chemical probes or function as agonists or antagonists of disease target(s) for therapy or immunotherapy. The NOFO is intended to support discovery research for the identification of validated hits relevant to health-related outcomes of participating NIH Institutes. Stages of discovery research covered by this NOFO include: 1) assay development for specific biological targets and disease mechanisms relevant to the mission of participating NIH Institutes with the intent to screen for small molecule compounds that show potential as probes for use in advancing knowledge about the known targets, identifying new targets, or as pre-therapeutic leads; 2) screen implementation high throughput target-focused approaches or moderate throughput phenotypic- and fragment-based approaches to identify initial screening hits; 3) hit validation, including implementation of secondary assays that are orthogonal to the primary assay, advanced cheminformatics analysis and initial medicinal chemistry inspection to prioritize the hit set, and follow-up assays to characterize mode and mechanism of action of the validated hits; 4) hit-to-lead optimization, including SAR to optimize target engagement, selectivity and to minimize chemical liabilities, ADME, PK and PD studies, and, if appropriate, in vivo modeling to test efficacy or biological effects.

This funding opportunity provides financial support for researchers to analyze existing data on late talking children, particularly focusing on underrepresented populations, to better understand their developmental trajectories and improve language outcomes.

This funding opportunity supports research projects that explore the link between social isolation and suicide risk in older adults, encouraging innovative interventions and service delivery models to enhance social connections and mental health.

This grant provides funding for research teams to study how early-life social and environmental factors influence brain development and addiction risk using animal models and advanced neuroscience techniques.

This cooperative agreement establishes the Hepatitis C Training and Implementation Center (HC-TIC) Network, which aims to accelerate the integration of hepatitis C prevention, testing, care coordination, and treatment interventions (program implementation) in priority high-impact settings through training and implementation TA. This cooperative agreement will improve and sustain the quality, availability, and reach of hepatitis C prevention and care activities in priority high-impact settings. Protection of public health and safety through the control and prevention of disease, injury, and disability in the U.S. and worldwide with attention to infectious disease, food borne pathogens, environmental health, occupational safety and health, health promotion, injury prevention and educational activities.

This funding opportunity provides financial and technical assistance to partners for projects that restore aquatic connectivity and improve fish passage in rivers, floodplains, and coastal habitats, benefiting ecosystems and local communities.

This funding opportunity provides financial support to collaborations involving state utility commissions, grid operators, and large electricity users to develop innovative solutions for managing increasing electricity demand while keeping costs low for consumers.

With this solicitation, OJJDP seeks to support states implementation of innovative and/or research-based, data-informed policies to improve juvenile justice system outcomes and sustainable strategies for reinvesting resulting costs saved or averted into effective delinquency prevention and intervention programs.Eligibility This solicitation is composed of two grant categories. Applicants must clearly designate the category for which they are applying. Category 1: Juvenile Justice System Reform State governments Category 2: Juvenile Justice System Reform Training and Technical Assistance Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public- and state-controlled institutions of higher education Private institutions of higher education For-profit organizations other than small businesses Small businesses