Grants for Public and State controlled institutions of higher education - Federal

The purpose of this Funding Opportunity Announcement (FOA) is to correlate immune system development patterns between two or more age groups - neonates, infants, and children and adolescents and further understand the impact of infectious diseases, microbiome and environmental factors on the ontogeny and development of the pediatric immune system, from birth, transitioning into adolescence and adulthood with the focus of impact during pregnancy and post-natal period.Purpose The purpose of this Funding Opportunity Announcement (FOA) is to correlate immune system in general and development patterns in particular, between two or more age groups - neonates, infants, and children and adolescents and further understand the impact of infectious diseases, microbiome and environmental factors on the ontogeny and development of the pediatric immune system, from birth, transitioning into adolescence and adulthood with the focus of impact during pregnancy and post-natal period. Background Worldwide, mortality in children under the age of 5 is predominantly due to infectious diseases and immune modulations associated with these infections. Pediatric immune system is remarkably different from adult immune system and also forms the basis for overall wellbeing and providing an adequate disease encountering status to adulthood. A protected and systematically trained pediatric immune system results in a robust and efficient adult immune system. Moreover, immune system in children responds strongly, rapidly and robustly in comparison to adult immune system to immunization, diet and environmental factors. Knowledge of development of the pediatric immune system in response to exposure to childhood infections and vaccinations, microbiome and the environmental factors can help chart pathways that provide strategies to prevent and treat infectious diseases more efficiently. These variations between pediatric and adult immune systems offer insight into better understanding strategies for developing immune-therapeutics and vaccines against infections. The research focus in the current announcement is multi-disciplinary. The focus however is in the areas of immune ontogeny and development, the mechanisms of infant and neonatal immunity or relationship between ontogeny of immunosuppression, susceptibility to infection during infancy or studies on effect of early infections or vaccinations that train the immune system. It is expected to diversify areas in existing research and draw comparisons between age groups or specific organ system development (for example, projects of interest might investigate immune cell ontogeny in lung alveoli from infancy to adult hood or immune alterations due to exposure to a specific immunogen (like measles or BCG vaccine) at infancy vs adolescence and the chronic effect of air pollution). More specifically, the aim here is to elucidate immune system development patterns in infants, children and adolescents focusing on both the innate immunity and the development of diverse antibodies or T cell maturation, with relevance to chronic infections (not limited to HIV, CMV, TB and the current SARS-CoV2 pandemic as well). Further, the intention is to expand the science to include additional internal factors like microbial metabolites and/or external factors like the environment that modulate the developing immune system so that a research program that is multi-disciplinary can be developed to address the interaction between host and pathogen. Research Scope The over-arching scope of this FOA is: to correlate immune system in general and development patterns in particular, between two or more age groups - neonates, infants, and children and adolescents to understand the evolution or immune ontogeny in human immune system development focusing on either or both, innate and adaptive immune systems with additional focus on internal factors like the microbiome and/or external factors like the environment. Further, the scope can be covered under these following topics and is not limited to: Study in young children vs adolescents vs adults, development of immunity and variations in immune system in physiology and in response to infectious diseases focusing on MTCT diseases (HIV, CMV, TB, Syphilis, SARS-CoV2 etc.), not limited to, broadly neutralizing antibodies (bNAbs), development of mucosal antibodies, germinal center formation and maturation; correlate with T cell development and identification of immunogens that activate T cells without enhancing infection. Characterize the impact of age, environmental factors, microbial metabolites and microbiome composition in relation to the immune responses against acute or chronic infectious diseases not limited to HIV, TB, CMV, SARS-CoV2 etc., and their contribution towards the development of a robust immune system development using novel technologies (RNA seq, imaging of immunogens and cellular interactions, single cell imaging). Understand cellular and soluble immune system components and the developmental pathways, including the microbiome, that regulate these components in specific age-groups. For example, developing immune profiles of HIV exposed un-infected (HEU) infants in comparison with the immune profile of an adolescent living with HIV and how these immune alterations prepare the immune system to encounter future infections. Study the contribution of increased exposure to environmental factors, pathogens, extensive or scheduled immunization early in life on enhanced cross-talk between innate and adaptive immune systems; specific inflammatory responses generated by innate immune factors and their downstream effect on cellular immune development. Delineate the role of human microbiome in health and disease and the environmental factors to observe correlation of immune responses against acute and chronic infections and focus on transfer of microbes and immune factors from human milk to infants. For example, assess alterations in immune profiles of known oral microbial clusters in CMV infected child vs immune profiles in an adolescent. Understand the impact of variations of microbiome in specific organ systems (gut vs oral vs vaginal microbiomes) in age defined profiles and their effect on immune ontogeny with emphasis on Virome . Influence of maternal microbiome on the effect of microbial composition and development of immunity in the offspring; detailed studies exploring placental microbiome and correlation with maternal oral microbial microbiome are encouraged. Projects that will be considered non-responsive for this FOA include, but are not limited to: Applications proposing vaccine advocacy. Applications proposing to focus exclusively on effects of microbiome and not studying the relevance of these effects on immune system development. Applications proposing to focus exclusively on epigenomic approaches. Applications focusing on immunization strategies in infants for altering early immune responses.

This grant provides funding for research projects aimed at improving the diagnosis and treatment of health conditions related to the September 11, 2001, terrorist attacks, specifically for individuals who were exposed in New York City and surrounding areas.

This funding opportunity provides financial support to states and organizations for developing a coordinated care model that improves health services for children with serious, long-term medical conditions.

This funding opportunity is designed to support public-private partnerships that leverage artificial intelligence to improve the resilience and competitiveness of U.S. manufacturing through innovative research and workforce development.

This grant provides funding to strengthen the management and evaluation of human resources in Malawi's national HIV and TB programs, focusing on hiring skilled personnel to support epidemic control efforts.

The purpose of the USAID Usalama ya Afya Duniani activity is to support the strengthening of Tanzanias capacities to develop, validate, and implement interventions to prevent, detect, and respond to EID threats in Tanzania using a One Health approach.The United States Agency for International Development (USAID) Mission in Dar es Salaam, Tanzania is publishing this Request for Information (RFI) to obtain information and inputs from all capable and interested entities for the anticipated USAID Usalama wa Afya Duniani activity. This activity is designed to identify and implement proven, collaborative, and evidence-based Global Health Security approaches in Tanzania, in support of strengthening the country’s capabilities to prevent, detect and respond to emerging infectious disease outbreaks.

Dear Interested Applicants:This Annual Program Statement (APS) publicizes in accordance with ADS 303.3.5.2(b) as the intention of the United States Government (USG), as represented by the United States Agency for International Development (USAID), Indonesia Mission, to fund one or multiple awards to improve the capacity of the National Tuberculosis Program, local partners, and communities to effectively detect, diagnose, and treat people affected by tuberculosis and provide preventive services to all people in need, while building a sustainable and resilient health system in Indonesia.This document is an umbrella APS that is not calling for any submission and will not solicit any concept papers nor applications. Prospective applicants will be provided a fair opportunity to develop and submit competitive applications to USAID for potential funding via APS Addendums under this APS. USAID Indonesia intends to make several assistance awards with US and local NGOs to assist the Government of Indonesia (GOI) in accelerating achievement toward its 2030 TB elimination.Following this APS, USAID will issue APS Addendum(s) with more detailed information for applicants to submit their applications. USAID Indonesia may utilize co-creation with prospective applicants during various stages of APS Addendum procurements and applicants may be invited to participate in virtual or in-person events. If/when there is any change related to this APS, the mission will amend this APS accordingly.Issuance of this APS does not commit USAID to make any awards nor to pay for the costs incurred in the preparation and submission of an application. USAID also reserves the right to reject any application received in response to the APS Addendum(s). USAID reserves the right not to conduct a co-creation and request Full Applications from successful applicants at the concept paper stage, or to conduct co-creation at a later stage of the process. The actual number of awards under this APS is subject to the availability of funds and the viability of applications received. USAID also reserves the right to award multiple awards or no awards at all through this APS.This APS and the APS Addendum will be posted on www.sam.gov and www.grants.gov. It is the responsibility of the Applicant to regularly check both websites to ensure they have the latest information pertaining to this APS and to ensure that the APS has been received from the internet in its entirety. USAID bears no responsibility for any data errors resulting from transmission or conversion process. If you have difficulty registering on www.grants.gov or accessing the APS document, please contact the Grants.gov Helpdesk at 1-800-518-4726 or via email at [email protected] for technical assistance.Thank you for your interest in USAID programs.

Through this cooperative agreement, the Office of Head Start (OHS) within the Administration for Children and Families (ACF) will make available the funds to enhance coordination and collaboration between the Office of Head Start (OHS) Region XII Office, the OHS Training and Technical Assistance system, Head Start recipients, other providers of early care and education, and stakeholders that provide services related to the development and learning of low-income migrant and seasonal worker children and families. The Collaboration office will promote partnerships with child care that emphasize the Early Head Start-Child Care Partnership Initiatives; collect data regarding early childhood programs and child outcomes; support the expansion and access of high quality workforce and career development opportunities for staff; work with school systems to ensure continuity between Head Start and school system goals; and, support other regional office priorities such as family and community partnerships; and, health, mental health, and oral health.

This grant provides funding for researchers and organizations to utilize uncrewed systems data to address urgent climate challenges and enhance NOAA's capabilities in climate adaptation, resilience, and mitigation efforts.

The U.S. Embassy Yaound Public Diplomacy Section (PDS) announces the availability of funding through its Public Diplomacy Small Grants Program. This is an annual request for Statements of Interest (SOI), outlining funding priorities, strategic themes, and procedures for submitting requests for funding. Please carefully read and follow all instructions below. The submission of a SOI is the first step in a two-part process. Applicants must first submit a SOI, which is a concise, 3-page concept note designed to clearly communicate a program idea and its objectives before the development of a full proposal application. The purpose of the SOI process is to allow applicants the opportunity to submit program ideas for evaluation prior to undertaking the development of full proposal. Upon review of eligible SOIs, PDS will invite selected applicants to expand their ideas into full proposal applications. Purpose of Small Grants: The PDS grants program supports projects proposed by U.S. and Cameroonian academic, cultural, educational, and other non-profit organizations and/or individuals that promote U.S. values, increase understanding between U.S. and Cameroonian people and institutions, and/or support U.S. Embassy goals of promoting government transparency and accountability, economic prosperity, peace and security, environmental sustainability, and climate adaptation. All programs must include an element of American culture or society, or connection with American expert/s, organization/s, or institution/s that will promote increased understanding of U.S. policy and perspectives. Priority Program Areas: Governance: Projects promoting democratic principles, improved and inclusive governance, transparency, human rights, religious freedom, empowerment of marginalized groups, citizen engagement, including in elections, civic education, and civil society. Prosperity: Projects promoting economic prosperity, entrepreneurship, bilateral trade and investment, countering corruption Security: Projects promoting peace and security, rule of law, alternatives to violence in resolving conflict, tolerance, preventing radicalization to violence, improving mutual understanding between groups, community policing Sustainability and Climate Change: Projects promoting environmental sustainability and addressing climate change Journalism: Projects promoting a professional and independent media, role of informed citizens in a democracy, media literacy, ethical and investigative journalism. Examples of PDS Small Grants Programs include, but are not limited to : U.S. experts conducting lectures, seminars, or speaking tours with Cameroonian audiences Artistic and cultural workshops, joint performances, and exhibitions Cultural heritage conservation and preservation programs Professional and academic exchanges and programs Libraries, community centers, or other institutions that are interested in becoming an American Space Programs developed by an alumnus/a of a U.S. sponsored or supported educational or professional exchange program Projects to promote English language teaching skills or widen access to books and other sources of information about the United States

The "Facilitating Preclinical and Early Phase Human Studies for New Therapeutics" grant aims to fund research that advances new treatments from preclinical stages to first-in-human trials for aging-related conditions, excluding neurodegenerative and Alzheimer's diseases, with a focus on improving injury repair in older adults and defining clear milestones for progress monitoring.

This grant provides funding to early-stage researchers exploring innovative chemical and pharmacological approaches to understanding and treating substance use disorders.

This grant provides funding for technology demonstrations of non-lithium long-duration energy storage solutions, targeting state energy offices, Indian Tribes, educational institutions, electric utilities, and private energy storage companies to advance these technologies towards commercial viability.

This funding opportunity provides financial support to accredited residency programs in primary care to enhance training in street medicine, focusing on delivering comprehensive healthcare to individuals experiencing homelessness.

The STRIPE program grant is designed to fund pre-clinical research that explores how radiopharmaceutical therapy affects cancer cells and their environment, with the aim of developing new targeting strategies and informing the design of future RPT-based clinical trials.

This project will increase the capacity of countries to develop effective regulations preventing the proliferation and misuse of commercial spyware in alignment with international best practices and advocate for commercial spyware regulatory approaches that are technically sound and rights-respecting.

This funding opportunity supports innovative interventions to improve the health and quality of life for people living with HIV, particularly those from racial and ethnic minority populations and low-income backgrounds, by addressing related health issues and promoting successful aging.

This funding opportunity supports collaborative research teams focused on innovative solutions to improve treatments and outcomes for patients with glioblastoma, particularly the IDH-wild type variant.

This funding opportunity provides financial support for U.S. organizations to host workshops, symposiums, and conferences that advance research and collaboration in space and Earth sciences and technology.

This funding opportunity supports innovative research projects aimed at improving mental health services and addressing disparities in access and quality, particularly for underserved populations.