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Grants for Small businesses - Federal

Explore 1,545 grant opportunities

Drug-Free Communities (DFC) Support Program - Competing Continuation (Year 6)
$125,000
U.S. Department of Health & Human Services (Centers for Disease Control - NCIPC)
Federal

Application Deadline

May 5, 2025

Date Added

Aug 2, 2024

This funding opportunity provides financial support to community coalitions focused on preventing and reducing youth substance use, helping them implement effective strategies and strengthen local partnerships.

Health
City or township governments
U.S. Army Corps of Engineers Research Grant for Defense and Engineering Innovation
Contact for amount
U.S. Army Corps of Engineers (USACE) Engineer Research and Development Center (ERDC)
Federal

Application Deadline

Not specified

Date Added

Mar 18, 2025

This funding opportunity is designed to support innovative prototype projects in military and civil engineering, targeting nontraditional defense contractors, traditional defense contractors, and nonprofit research institutions.

Science and Technology
Public and State controlled institutions of higher education
BJA FY25 Preventing Violence Against Law Enforcement Officers and Ensuring Officer Resilience and Survivability (VALOR) Initiative
$6,000,000
U.S. Department of Justice (Bureau of Justice Assistance)
Federal

Application Deadline

Feb 5, 2026

Date Added

Jan 14, 2026

This funding opportunity provides financial support to law enforcement agencies across the U.S. to enhance officer safety, wellness, and resilience through comprehensive training and resources.

Safety
Nonprofits
Harnessing Autonomy For Energy Joint Ventures Offshore Sbir/STTR (Haejo Sbir/STTR)
$4,505,859
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Feb 13, 2025

Date Added

Jan 15, 2025

This grant provides funding to small businesses in the U.S. to develop innovative technologies that address critical national needs, particularly in health and technology, while promoting collaboration with research institutions.

Opportunity Zone Benefits
Small businesses
Supporting the provision of person-centered, equitable, high-quality, and integrated service delivery towards a sustainable and resilient HIV/TB response in the Kingdom of Eswatini under PEPFAR
$4,000,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Mar 5, 2025

Date Added

Jul 19, 2024

This grant provides funding to local organizations in Eswatini to improve and integrate HIV and TB prevention and treatment services, enhancing the capacity of health institutions and ensuring community involvement in the process.

Health
State governments
Critical Facility Energy Resilience (CiFER)
$5,000,000
U.S. Department of Energy (National Energy Technology Laboratory)
Federal

Application Deadline

Oct 4, 2024

Date Added

Aug 6, 2024

The "Critical Facility Energy Resilience (CiFER)" grant aims to fund the development and commercial deployment of innovative energy storage technologies, specifically at sites with identified resiliency needs, to enhance their progress towards commercialization.

Energy
Nonprofits
Institutional Network Award for Promoting Kidney, Urologic, and Hematologic Research Training (U2C - Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 26, 2025

Date Added

Aug 1, 2023

This funding opportunity supports institutions in creating collaborative training networks for early-career researchers focused on advancing studies in kidney, urologic, and hematologic diseases.

Food and Nutrition
State governments
Re-X Before Recycling Prize Phase 3
$150,000
U.S. Department of Energy
Federal

Application Deadline

Dec 8, 2025

Date Added

Jul 29, 2024

This grant provides funding and technical support to innovators and organizations developing sustainable solutions for reusing and repurposing end-of-life products, promoting a circular economy and reducing waste.

Environment
Nonprofits
Centers for AIDS Research (P30 Clinical Trial Not Allowed)
$3,250,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Aug 4, 2025

Date Added

Mar 9, 2023

This funding opportunity provides substantial financial support to higher education institutions and nonprofit organizations to establish collaborative centers that advance research and resources for HIV/AIDS.

Education
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Investigational New Drug (IND)-enabling and Early-Stage Development of Medications to Treat Alcohol Use disorder and Alcohol-Associated Organ Damage (R41/R42 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Apr 5, 2025

Date Added

Nov 26, 2024

This funding opportunity is designed to support small businesses in developing innovative medications for treating alcohol use disorder and related organ damage, helping them advance their drug candidates toward FDA approval.

Health
Small businesses
Co-infection and Cancer (R01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 17, 2024

Date Added

Dec 14, 2022

Grant Title: Co-infection and Cancer (R01 Clinical Trial Not Allowed) - This grant aims to improve our understanding of how co-infections (excluding HIV) contribute to cancer, particularly in under-studied populations, to identify new prevention and treatment strategies.

Education
State governments
Forecast to Renew the Funding Opportunity Announcement for Multiple Chronic Disease Research Centers Coordinating Center (U24 Clinical Trial Not Required)
$20,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 26, 2025

Date Added

May 28, 2025

This funding opportunity supports organizations in coordinating research efforts to address multiple chronic diseases and reduce health disparities, particularly in underserved communities.

Health
State governments
Sustainable Regional Systems Research Networks
$30,000,000
National Science Foundation
Federal

Application Deadline

May 15, 2024

Date Added

Jan 27, 2024

The United States is made up of regional systems comprising interdependent urban and rural systems and every community category between urban and rural. Urban systems and rural systems are interdependent for the provisioning of food, energy sources, water, other materials and natural resources, markets, manufactured goods, and medical resources. These systems are also connected by ecological processes that both influence and are influenced by human behavior. The vital interconnection of urban-rural systems underscores the critical need for the advancement of sustainable regional systems (SRS). The goal of this solicitation is to fund convergent research and education that will advance sustainable regional systems science, engineering, and education to facilitate the transformation of current regional systems to enhance sustainability. To further the advancement of SRS science, engineering, and education, NSF will support proposals for Sustainable Regional Systems Research Networks (SRS RNs). Sustainable regional systems are connected urban and rural systems that are transforming their structures and processes collaboratively with the goal of measurably and equitably advancing the well-being of people and the planet. The purpose of the SRS RNs competition is to develop and support interdisciplinary, multi-organizational teams working collaboratively to produce cutting-edge convergent research, education, and outreach that addresses grand challenges in sustainable regional systems. SRS RNs will study multiscale regional systems to further SRS science, engineering, and education. Key elements will include new data, methods, and models to understand interactions between natural, human-built, and social systems; improved understanding of interdependencies, mutual benefits, and trade-offs of different wellbeing outcomes for humans and the environment; new and generalizable theories of change relevant to SRS;theco-production of knowledge; andexploration of conceptsof social equity in sustainable regional systems across spatial and temporal scales. SRS RN outcomes will have the potential to inform societal actions for sustainability across urban systems and the connected rural communities that make up regional systems. Subject to availability of funds and quality of proposals, this SRS RN solicitation will support: SRS RN Awards.These awards will supportfundamental convergent research, education, and outreach that addressesengineering, chemistry, biology, geosciences, mathematics, statistics, environmental, data, computational, education, and social, behavioral, and economic sciences ofsustainable regional systems in partnerships thatmay embrace universities, colleges, federal, state, and local governments, tribal communities, non-governmental and international bodies, non-profit organizations, industry, practitioners, and other community groups. The award size is up to $15 million totalwith a duration of 5 years. SRS RNs will conduct innovative and pioneering fundamental research and education that is of a scale and complexity that would not be possible within a single organization, center, or through the normal collaborative modes of NSF research support in core programs.

Science and Technology
For profit organizations other than small businesses
BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)
$350,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 28, 2025

Date Added

May 23, 2025

This funding opportunity supports the development of innovative computational tools to analyze complex brain data, inviting a diverse range of researchers and organizations to enhance our understanding of neural circuits and their functions.

Science and Technology
Public and State controlled institutions of higher education
DoD Peer Reviewed Cancer, Virtual Cancer Center Director Award
$1,750,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 15, 2024

Date Added

Jun 18, 2024

The DoD Peer Reviewed Cancer, Virtual Cancer Center Director Award is a funding opportunity for established cancer researchers to create and lead a virtual cancer center, which aims to foster collaboration, mentorship, and innovative research among early career investigators across different cancer disciplines, with a focus on convergent science and the development of collaborative seed projects.

Science and Technology
Nonprofits
Strengthening national laboratory and HIV epidemiologic monitoring capacities and systems to enhance an efficient, resilient and self-reliant response to HIV, TB and related public health threats in the Kingdom of Eswatini under PEPFAR
$5,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This grant provides funding to strengthen laboratory and disease monitoring systems in Eswatini, enhancing the country's ability to effectively respond to HIV, tuberculosis, and other public health threats.

Health
State governments
Geothermal Resources’ Value in Implementing Decarbonization (GRID)
$1,500,000
Department of Energy, Office of Clean Energy Demonstrations (OCED)
Federal

Application Deadline

Sep 9, 2024

Date Added

Jul 17, 2024

The Geothermal Resources’ Value in Implementing Decarbonization (GRID) FOA aims to advance the Biden-Harris Administration's goals for a carbon-pollution-free electricity sector by 2035 and a net-zero emissions economy by 2050. The program focuses on regional grid modeling studies to quantify geothermal power's potential contribution to a decarbonized grid. Eligible applicants must submit a Letter of Intent by July 24th, 2024, and full applications by September 9th, 2024. The program offers funding between $500,000 and $1,500,000, with an estimated total funding of approximately $7 million.

Energy
Small businesses
Advancing Genomic Medicine Research (R21 Clinical Trial Optional)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 11, 2025

Date Added

Nov 20, 2024

This funding opportunity supports innovative research projects that aim to improve the use of genomic information in clinical care, particularly for diverse populations, with a focus on health outcomes and addressing disparities.

Education
State governments
Rural Healthcare Provider Transition Project
$800,000
U.S. Department of Health & Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Apr 14, 2025

Date Added

Jul 15, 2024

This funding opportunity provides financial support to small rural hospitals and health clinics to help them improve their healthcare services and transition to a value-based care system for better patient outcomes.

Health
State governments
NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)
$100,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 7, 2025

Date Added

Nov 20, 2024

This funding opportunity provides financial support to early-career researchers in the dental and craniofacial fields to conduct pilot studies that will help them secure larger research grants in the future.

Health
State governments