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Grants for Small businesses - Federal

Explore 1,545 grant opportunities

Enhancing Reuse of NHGRI Data Assets (R03 Clinical Trial Not Allowed)
$125,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 15, 2026

Date Added

Nov 19, 2024

This funding opportunity supports innovative research projects that utilize genomic data from a specific cloud-based platform to answer important biological questions and improve data accessibility for the scientific community.

Health
State governments
DoD Tick-Borne Disease, Therapeutic/Diagnostic Research Award
$2,656,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Oct 3, 2024

Date Added

Apr 24, 2024

The "DoD Tick-Borne Disease, Therapeutic/Diagnostic Research Award" is a grant aimed at supporting the development of new treatments and diagnostic methods for tick-borne diseases, with a focus on improving patient care and quality of life for military service members, veterans, their families, and the general public.

Science and Technology
Nonprofits
NIMH Biobehavioral Research Awards for Innovative New Scientists (NIMH BRAINS) (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 20, 2025

Date Added

Jul 26, 2022

This grant provides funding to early-career researchers in mental health to support innovative projects that advance the understanding and treatment of mental illnesses.

Health
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Academic Career Excellence (ACE) Award (K32 Independent Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 12, 2025

Date Added

Dec 27, 2024

This funding opportunity supports early-stage postdoctoral researchers in cancer research by providing resources for structured training and professional development to advance their scientific careers.

Health
State governments
Microglial Pathophysiology in Comorbid Substance Use Disorder (SUD) and HIV (R61/R33 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Aug 14, 2025

Date Added

Aug 26, 2024

This grant provides funding for researchers to study how HIV and substance use disorder affect brain cell function, with the goal of uncovering new treatment strategies for individuals facing these combined challenges.

Education
State governments
Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 5, 2024

Date Added

Aug 15, 2023

This Notice of Funding Opportunity (NOFO) aims to support research on interdisciplinary population approaches to increasing awareness of the relationship between alcohol and cancer risk, understanding and changing social norms related to alcohol consumption, developing and/or evaluating alcohol policy approaches, and the development, testing, and implementation of population-level interventions to reduce alcohol-related cancer risk. Applications that address multiple levels of consumption, such as moderate and heavy drinking, are of particular interest, as well as those focusing on alcohol use disorder (AUD) from the perspective of cancer prevention and control. Proposals addressing understudied areas are encouraged, as is attention to underrepresented minority (URM) populations experiencing cancer and alcohol-related disparities such as American Indian, Alaskan Native, and sexual and gender minority populations.

Education
State governments
Mechanisms for Amplification of fusion Reaction Rates in Solids (MARRS)
Contact for amount
U.S. Department of Defense (DARPA - Defense Sciences Office)
Federal

Application Deadline

Mar 12, 2026

Date Added

Dec 31, 2025

This grant seeks innovative research proposals to explore and amplify nuclear fusion reaction rates in solid materials at or near room temperature, targeting advancements for practical applications in national defense and energy generation.

Science and Technology
For profit organizations other than small businesses
Notice of Intent to Publish a Funding Opportunity for Maximizing the Scientific Value of Data Generated by the Environmental influences on Child Health Outcomes (ECHO) Program: Dissertation Grant (R36)
$45,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 17, 2025

Date Added

Nov 26, 2024

This funding opportunity supports doctoral candidates conducting research on maternal and child health using a large dataset to explore the impact of early environmental exposures on child health outcomes.

Health
State governments
Enhancing sustainable and integrated health, strategic information, and laboratory systems for quality comprehensive HIV services through technical assistance to the Republic of Rwanda under the President's Emergency Plan for AIDS Relief (PEPFAR)
Contact for amount
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This funding opportunity provides financial support to various organizations working to strengthen Rwanda's health systems and improve comprehensive HIV services through technical assistance and capacity building.

Health
State governments
Appalachian Region Healthcare Support Program
$1,500,000
Department of Health and Human Services Health Resources and Services Administration
Federal

Application Deadline

Jul 25, 2024

Date Added

Jun 26, 2024

The Appalachian Region Healthcare Support Program provides technical assistance (TA) to help rural healthcare organizations, including critical access hospitals (CAHs), small rural hospitals, rural health clinics, tribal healthcare facilities, and other healthcare organizations located in the rural counties served by the Appalachian Regional Commission (ARC) with planning and implementing health care service improvements. The goal of this program is to strengthen healthcare delivery in rural areas of the Appalachian Region by improving financial and operational performance as well as the quality of care in rural healthcare organizations. The TA provider funded under this cooperative agreement will work with individual healthcare organizations to meet the following program objectives: Provide objective analysis and assessment of healthcare organizations financial status, market share, quality indicators, locally available human services, and gaps in services so that organizations can make actionable change; Identify clinical areas where expansion of services within a rural healthcare organization would meet local need, keep health care services available locally, and build capacity to improve financial and operational performance as well as quality of care. Support healthcare organizations in implementing best practice recommendations prioritized in TA action plans. For purposes of this notice of funding opportunity, rural healthcare organization is a health care organization located in a rural area in the Appalachian Region. A healthcare organization includes critical access hospitals, small rural hospitals, rural health clinics, tribal healthcare facilities, and other healthcare organizations. To determine if a health care organization is located in a rural area, visit https://data.hrsa.gov/tools/rural-health. To determine if a county is in the Appalachian Region, visit https://www.arc.gov/appalachian-counties-served-by-arc.For more details, see Program Requirements and Expectations.

Health
State governments
DoD Epilepsy Idea Development Award
$4,560,000
DOD-AMRAA (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Jun 20, 2024

Date Added

Mar 26, 2024

The intent of the FY24 ERP IDA is to solicit novel, innovative research that has the potential to increase our understanding of PTE to improve quality of life, especially in Service Members, Veterans, and/or their care partners. The work should innovatively challenge existing research paradigms or exhibit high levels of creativity. The FY24 ERP IDA offers two levels of funding dependent upon the level of experience of the Principal Investigator (PI). Funding Level I - Pathway to Independence Option: Early-career investigators ranging from the postdoctoral level (e.g., research associate, fellows, residents, or equivalent) to within 3 years of their first independent faculty position (or equivalent) may be named by the organization as the PI on the application (mentor required). Funding Level II - Innovative New Direction Option: Investigators at all career levels may be named by the organization as the PI on the application.

Science and Technology
Nonprofits
Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R01 - Clinical Trial Optional)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 5, 2025

Date Added

Oct 18, 2024

Grant Title: Towards a Better Understanding of the Neurological Effects of Infection-Associated Chronic Illnesses (R01 - Clinical Trial Optional) aims to support research on the neurological and mental health impacts of chronic illnesses triggered by infections, such as post-COVID conditions and myalgic encephalomyelitis, focusing on their underlying mechanisms and potential treatments.

Health
State governments
PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 5, 2025

Date Added

Jul 5, 2024

This funding opportunity is designed for U.S. small businesses to develop and commercialize innovative health-related technologies through clinically informed research projects that include a clinical trial.

Education
Small businesses
Strengthening civil society organizations' capacity and coordination to accelerate HIV epidemic control in Uganda by implementing comprehensive HIV/AIDS prevention and treatment for key and priority populations under PEPFAR
$10,000,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 18, 2025

Date Added

Jul 19, 2024

This grant provides funding to civil society organizations in Uganda to strengthen their capacity and coordination in delivering comprehensive HIV prevention and treatment services to key and priority populations at high risk of HIV infection.

Health
State governments
Early and Late Stage Clinical Trials for the Spectrum of Alzheimers Disease/Alzheimers Related Dementias and Age-Related Cognitive Decline (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 6, 2024

Date Added

Dec 23, 2022

The purpose of this Funding Opportunity Announcement (FOA) is to 1) invite applications that propose to develop and implement early to late stage clinical trials of promising pharmacological and non-pharmacological interventions for cognitive and neuropsychiatric changes associated with age-related cognitive decline and Alzheimer's disease (AD) and Alzheimer's disease-related Dementias (ADRD) across the spectrum from pre-symptomatic to more severe stages of disease, and 2) stimulate studies to enhance trial design and methods.

Health
State governments
STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 23, 2025

Date Added

Apr 2, 2025

This funding opportunity supports U.S. colleges and universities with limited research funding to assess their biomedical research capabilities and develop strategic plans to enhance their research infrastructure and capacity.

Education
State governments
NEI Collaborative Clinical Vision Research: Chair's Grant (UG1-Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 25, 2026

Date Added

May 25, 2023

This funding opportunity supports complex clinical trials aimed at improving screening, diagnosis, prevention, or treatment of vision disorders, targeting researchers and institutions capable of leading high-risk studies with significant public health impact.

Health
State governments
Bison Production and Marketing Grant Program
$2,000,000
U.S. Department of Agriculture (Agricultural Marketing Service)
Federal

Application Deadline

Apr 22, 2025

Date Added

Jan 17, 2025

This program provides funding to organizations that improve bison production and marketing, particularly benefiting small farms, tribal groups, and underserved communities across the United States.

Agriculture
Native American tribal organizations
Research Interests of the United States Air Force Academy (formerly USAFA-BAA-2021)
$99,000,000
U.S. Department of Defense (Air Force Academy)
Federal

Application Deadline

Dec 2, 2025

Date Added

Dec 2, 2020

This grant provides funding for research projects that enhance cadet education, support faculty development, and improve the operational capabilities of the Air Force, while fostering collaboration with industry partners.

Science and Technology
For profit organizations other than small businesses
DoD Epilepsy Leveraging Research Award
$2,400,000
DOD-AMRAA (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Jun 20, 2024

Date Added

Mar 26, 2024

The intent of the FY24 ERP LRA is to leverage ongoing or completed research studies for which PTE was not an original focus and to provide support to expand the research to develop such a focus and increase our understanding of PTE. The project may include basic, translational, and/or clinical research studies. The study must be associated with an ongoing or completed research effort in which PTE is/was not a research priority and for which addition of cohorts, outcomes, assessments, or analysis specific to PTE would be scientifically justified to increase our understanding of PTE. Examples of allowable research include but are not limited to: Secondary analysis of epilepsy surveillance data to evaluate PTE risk; Addition of a chronic TBI cohort in an ongoing preclinical animal study to evaluate seizure outcomes and epileptogenesis; Recruitment/Analysis of a PTE cohort within an ongoing observational longitudinal study for a known concomitant comorbidity of PTE such as depression, cognitive deficits, sleep disorder, etc.

Science and Technology
Nonprofits