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Grants for Small businesses - Federal

Explore 1,549 grant opportunities

Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)
$6,600,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 30, 2025

Date Added

May 15, 2025

This funding opportunity provides financial support for a variety of organizations to advance genomic research in pediatric cancers and congenital anomalies, fostering collaboration and innovation in understanding and treating these conditions.

Health
State governments
Strengthening economic analysis and capacity in support of program management for HIV, TB, and related health threats in South Africa (SA) under the President's Emergency Plan for AIDS Relief (PEPFAR)
$400,000
U.S. Department of Health & Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 20, 2025

Date Added

Jul 26, 2024

This grant provides funding to organizations in South Africa to improve economic analysis and capacity for managing HIV, tuberculosis, and related health issues, ultimately enhancing public health program efficiency and resource allocation.

Health
State governments
PHS 2024-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 5, 2025

Date Added

Jul 5, 2024

This funding opportunity supports U.S.-based small businesses in health-related fields to develop innovative technologies, with a focus on projects that can successfully transition to commercialization.

Education
Small businesses
Creutzfeldt-Jakob Disease (CJD) Increasing Educational Support for CJD Families and the Nation
$100,000
U.S. Department of Health & Human Services (Centers for Disease Control - NCEZID)
Federal

Application Deadline

Mar 18, 2025

Date Added

Aug 23, 2024

This funding opportunity provides financial support to organizations that aim to improve educational resources and public awareness for families affected by Creutzfeldt-Jakob disease and enhance national surveillance efforts for this rare neurological condition.

Health
State governments
HEAL Initiative: Research to Increase Implementation of Substance Use Preventive Services (R61/R33 Clinical Trial Optional)
$750,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 17, 2025

Date Added

Sep 22, 2023

This funding opportunity provides support for U.S.-based organizations to develop and implement effective substance use prevention services within various community systems, targeting individuals at risk or already misusing substances.

Education
State governments
Counterproliferation Finance
$256,537
DOS-ISN (Bureau of International Security-Nonproliferation)
Federal

Application Deadline

Jun 21, 2024

Date Added

May 16, 2024

To implement a project aimed at advancing U.S. foreign policy and national security priorities by supporting initiatives that is more reflective of and responsive to the needs and perspectives of partner states to ensure strategic trade control systems meet international standards and by engaging on bilateral, regional and multilateral levels with foreign governments to aid in the establishment of independent capabilities to regulate transfers of weapons of mass destruction, WMD-related items, conventional arms, and related dual-use items, and to detect, interdict, investigate, and prosecute illicit transfers of such items.

Law Justice and Legal Services
Nonprofits
Biology of Bladder Cancer (R21 Clinical Trial Optional)
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 16, 2025

Date Added

Nov 21, 2024

This funding opportunity supports innovative research into the biology and mechanisms of bladder cancer, particularly focusing on non-muscle-invasive bladder cancer, to improve understanding and develop new prevention or treatment strategies.

Education
State governments
OJJDP FY25 Family Treatment Court Training and Technical Assistance
$3,000,000
U.S. Department of Justice (Office of Juvenile Justice Delinquency Prevention )
Federal

Application Deadline

Mar 6, 2025

Date Added

Jan 17, 2025

This funding opportunity provides financial support to organizations that help family treatment courts improve services for parents facing substance use and mental health challenges in child welfare cases.

Law Justice and Legal Services
Public and State controlled institutions of higher education
University Leadership Initiative (ULI)
Contact for amount
NASA-HQ (NASA Headquarters)
Federal

Application Deadline

May 29, 2024

Date Added

Mar 1, 2024

Amendment 2 to the NASA ARMD Research Opportunities in Aeronautics (ROA) 2024 NRA has been posted on the NSPIRES web site. University Leadership Initiative (ULI) provides the opportunity for university teams to exercise technical and organizational leadership in proposing unique technical challenges in aeronautics, defining multi-disciplinary solutions, establishing peer review mechanisms, and applying innovative teaming strategies to strengthen the research impact.Research proposals are sought in six ULI topic areas in Appendix D.4.Topic 1: Safe, Efficient Growth in Global Operations (Strategic Thrust 1)Topic 2: Innovation in Commercial High-Speed Aircraft (Strategic Thrust 2)Topic 3: Ultra-Efficient Subsonic Transports (Strategic Thrust 3) Topic 4: Safe, Quiet, and Affordable Vertical Lift Air Vehicles (Strategic Thrust 4)Topic 5: In-Time System-Wide Safety Assurance (Strategic Thrust 5)Topic 6: Assured Autonomy for Aviation Transformation (Strategic Thrust 6)This NRA will utilize a two-step proposal submission and evaluation process. The initial step is a short mandatory Step-A proposal due May 29, 2024. Those offerors submitting the most highly rated Step-A proposals will be invited to submit a Step-B proposal. All proposals must be submitted electronically through NSPIRES at https://nspires.nasaprs.com.An Applicants Workshop will be held on Thursday Apr 3, 2024; 1:00-3:00 p.m. ET (https://uli.arc.nasa.gov/applicants-workshops/workshop8).An interested partners list for this ULI is at https://uli.arc.nasa.gov/partners. To be listed as an interested lead or partner, please send electronic mail to [email protected] with "ULI Partnerships" in the subject line and include the information required for the table in that web page.

Science and Technology
Nonprofits
Biological Technologies
Contact for amount
DOD-DARPA-BTO (DARPA - Biological Technologies Office)
Federal

Application Deadline

Jun 20, 2024

Date Added

Jun 22, 2023

This announcement seeks revolutionary research ideas for topics not being addressed by ongoing BTO programs or other published solicitations. This publication constitutes a Broad Agency Announcement (BAA) as contemplated in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016 and 2 CFR § 200.203. Any resultant award negotiations will follow all pertinent law and regulation, and any negotiations and/or awards for procurement contracts will use procedures under FAR 15.4, Contract Pricing, as specified in the BAA. BTO's mission is to develop capabilities that leverage the unique properties of biology - adaption, replication, resilience and complexity, to revolutionize how the United States defends the homeland and prepares and protects its Warfighters. Research in BTO creates biotechnological capabilities that provide tactical care and restore function to injured warfighters, increase operational resilience, develop novel functional materials, and detect and protect against threats to maintain force readiness.

Science and Technology
Public and State controlled institutions of higher education
State Offices of Rural Health Coordination and Development Program (SORHCDP)
$950,000
U.S. Department of Health and Human Services (Health Resources and Services Administration)
Federal

Application Deadline

Dec 9, 2024

Date Added

Jul 15, 2024

This funding opportunity provides financial support to organizations that aim to strengthen the capacity and collaboration of State Offices of Rural Health and improve healthcare services in rural communities across the United States.

Health
State governments
Mentored Career Development Program for Early Stage Investigators Using Nonhuman Primate Research Models (K01 Independent Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Not specified

Date Added

Jan 10, 2023

This funding opportunity supports early-stage researchers in the U.S. to develop expertise in using nonhuman primate models for biomedical research, with a focus on infectious diseases, neuroscience, and aging, through a structured mentorship program.

Health
State governments
Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts (U01 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 28, 2025

Date Added

Feb 12, 2025

Through this funding opportunity announcement, the National Cancer Institute (NCI) solicits applications to Cancer Epidemiology Cohorts: Building the Next Generation of Research Cohorts PAR. This funding opportunity announcement seeks to support initiating and building the next generation of population-based cancer epidemiology cohorts to address specific knowledge gaps in cancer etiology and survivorship. Specifically, it will support methodological work necessary to initiate and build cancer epidemiology cohorts that can address critical scientific gaps concerning (i) new or unique exposures in relation to cancer risks and outcomes and (ii) achievement of diverse populations in cohorts with the inclusion of understudied populations (e.g., racial/ethnic groups, rural populations, and persistent poverty areas) with substantial community engagement.

Education
State governments
Understanding the mechanisms underlying the age-related changes in gait biomechanics and the impact on the increased metabolic cost of walking (R01 Clinical Trial Optional)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 7, 2024

Date Added

Aug 27, 2024

This grant provides funding for researchers to investigate how aging affects walking mechanics and increases the energy cost of walking, encouraging innovative studies that combine various scientific disciplines and technologies.

Health
State governments
DRL Internet Freedom Annual Program Statement
$3,000,000
U.S. Department of State (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Jan 9, 2025

Date Added

Oct 3, 2024

This grant provides funding for organizations to develop projects that promote internet freedom, protect human rights online, and combat censorship and digital security threats.

Science and Technology
Nonprofits
Biological Laboratory Network Mapping Assessment and Optimization in Chile
$5,000,000
Department of State - Bureau of International Security-Nonproliferation
Federal

Application Deadline

Jul 22, 2024

Date Added

May 22, 2024

The Department of States Office of the Nonproliferation and Disarmament Fund (ISN/NDF) is pleased to announce an open competition for assistance awards through this Notice of Funding Opportunity (NOFO). ISN/NDF invites non-profit/non-governmental organizations, international organizations, educational institutions, US federal agencies and institutions, and for-profit organizations to submit proposals for projects that will advance the mission of NDFs biological threat reduction special project. Proposals may not exceed the total availability of funds under this NOFO. ISN/NDF will only consider proposals that fully address all NDFs lines of effort, which are further described in Section II, in their entirety.

International Development
Public and State controlled institutions of higher education
NSF National Resource Coordination Center on Improving Undergraduate STEM Education (IUSE)
$7,500,000
National Science Foundation
Federal

Application Deadline

Nov 14, 2024

Date Added

Aug 16, 2024

This grant provides funding to establish a center that will support and connect educators and researchers focused on improving undergraduate STEM education across the nation.

Science and Technology
For profit organizations other than small businesses
Energy Storage Innovations Prize
$50,000
U.S. Department of Energy (DOE) Office of Electricity (OE)
Federal

Application Deadline

Sep 10, 2025

Date Added

Dec 31, 2024

This grant provides funding for individuals and organizations to develop innovative energy storage solutions that cater to unique applications in underserved communities and extreme climates, promoting grid modernization and reliability.

Science and Technology
Small businesses
Announcement of Stand Down Grants
$10,000
U.S. Department of Labor (Veterans Employment and Training Service)
Federal

Application Deadline

Sep 30, 2025

Date Added

Jan 10, 2023

This program provides funding to organizations that host events offering essential services to veterans facing or at risk of homelessness, helping them reintegrate into the workforce.

Employment Labor and Training
Nonprofits
Mission Kampala Ambassador's Special Self-Help Fund 2024
$10,000
DOS-UGA (U.S. Mission to Uganda)
Federal

Application Deadline

Jun 4, 2024

Date Added

Apr 9, 2024

The 2024 SSH Notification of Funding Opportunity (NOFO) from the US Embassy in Uganda announces an open competition for registered organizations interested in submitting applications for the Ambassadors Special Self-Help (SSH) Program, which supports small-scale, community-based initiatives that promote self-reliance, foster development, widen civic space and engagement, protect and promote human rights, and promise an immediate and dramatic effect on local communities. Projects tailored to gathering spaces and targeted for vulnerable populations, promotion of gender and equity, civic participation, and the prevention of the negative effects of climate change are of particular interest this year. Entering its sixtieth year of continuous operation, the SSH program is a direct reflection of the U.S. governments commitment to helping Ugandans help themselves. The project must be submitted by an organized group, motivated, who has a real need, and has already worked with communities. The project should be feasible based on the socio-economic context and include the necessary information and documentation indicated on the form. Interested organizations can obtain an application from the Office of Self Help or download it here: Special Self-Help Fund Application (PDF 213 KB). The organization may also send its own drafted project provide that all needed information in the SSH application were answered in their proposal. The applicant should fill the form carefully with special emphasis on the following critical aspects of the proposed project: Objectives, impacts and key activities Implementation strategy Monitoring mechanisms Itemized budget The application should be sent to: Special Self-Help Coordinator U.S. Embassy Kampala Plot 1577 Ggaba Road, P.O. Box 7007 Kampala, Uganda [email protected] ELIGIBILITY INFORMATION C.1 Eligible Applicants The U.S. Embassy Kampala Small Grants Office welcomes applications from all established Uganda-based, non-profit organizations/Non-Governmental Organizations (NGO), Community Based Organizations (CBO), and grassroots organizations. The application must be submitted by an organization that is motivated, demonstrates a real need, and has already successfully implemented projects in the community. The project should be feasible and based on the socioeconomic context of the local community. To be eligible for funding, your project must meet the following criteria: Be community-based. Be initiated locally. Be administered at the local level; and Include substantial community participation and contributions in cash, labor, food, accommodation for qualified labor, transportation costs, or materials such as carts of sand or gravel, bricks for construction, fence materials, or water. Organizations that apply for SSH funds must be established and registered as Community Based Organizations (CBO) or Non-Governmental Organizations (NGO) at the local government level in the communities in which they work. Please provide registration certificate. Help improve basic economic or social conditions at the local community or village level and have long-lived value. Particular attention will be given to projects that focus of enhancing civic engagement, fiscal independence, and reduce the effects of climate change. The projects should be high impact, benefiting the greatest number of people possible. Funding is limited to one project, which must be completed within twelve (12) months or less. Projects must be self-sustaining upon completion. The U.S. Embassys support for the project must be a one-time-only/one grant contribution. Projects must be within the communitys ability to maintain and operate. Requests for large-scale agriculture or construction projects, or for expensive equipment are not considered priority projects. All applicants must display sound management in the form of financial and administrative procedures that protect against waste, fraud, and abuse. C.2 Cost Sharing or Matching Although providing a specific cost sharing, matching, or cost participation amount is not an eligibility requirement for this NOFO, the project proposal must include community participation and contributions in cash, labor, and/or materials as noted above in C.1. The Special Self-Help Program does NOT fund: Requests to buy equipment like vehicles, motorcycles, office equipment, computers, phones, tablets, copiers, and stereos. Salaries or supervision costs for the supervising organization. Contingency estimates also do not qualify. Labor, salaries, operating costs, printing material, fuel, or land. Payment for pesticides and herbicides Proposals that have a purely police, military, or cultural emphasis. Religious projects unless they genuinely assist the whole community without regard to religious affiliation. Personal businesses. Scholarships, donations, start-up money, loans or honorariums. HIV/AIDS projects. Projects that focus on refugees or displaced persons. There are specific U.S. bilateral or multilateral assistance programs designed to address those needs. Projects that the community cannot continue after the SSH funding cycle has ended. Projects that have received prior SSH funds. To remodel or renovate an existing facility that is in disrepair because of neglect or lack of money. Office supplies such as pencils, paper, forms, and folders. Projects that are partially funded by another donor or from the Government of Uganda. Funds cannot be commingled with funds from other donors, international organizations or other U.S. government programs. SSH funds may not be used to buy previously owned equipment, luxury goods, or gambling equipment. Activities that are the responsibility of the government, for example, building hospitals. Activities that could potentially create tension within the community, harm community members, or damage the environment. Sports equipment or uniforms for a national sport team. Musical instruments or uniforms for a national orchestra or dance company. Surveillance equipment. Abortion-related facilities and services. Payments to government officials. Ceremonies, parties, celebrations, or representational expenses. C.4 Other To be eligible to receive an award, all organizations must have a Unique Entity ID (UEI) Number or evidence of applying for a UEI. Any selected organization will be required to have a UEI for the grant to be issued. Organizations can register for a UEI at https://sam.gov/content/entity-registration . Please see Section D.3 for information on how to obtain these registrations. Any applicant listed on the Excluded Parties List System in the System for Award Management (SAM) (www.sam.gov) is not eligible to apply for an assistance award in accordance with the OMB guidelines at 2 CFR 180 that implement Executive Orders 12549 (3 CFR,1986 Comp., p.189) and 12689 (3 CFR,1989 Comp., p. 235), Debarment and Suspension. Additionally, no entity listed on the Excluded Parties List System in SAM can participate in any activities under an award. Lastly, applicants are only allowed to submit one proposal per organization. If more than one proposal is submitted from an organization, all proposals from that institution will be considered ineligible for funding. PROJECT EXAMPLES D.1 Elements of successful projects The project is initiated by the community. The project benefits the greatest number of people within the community. The project plan contains pre-established long-term goals and a coherent plan to keep the project running in the future. A capable project manager who is a long-term resident in the community is responsible for the project. The project is assisted by a non-biased umbrella organization, such as a religious mission or a local NGO that provides guidance and arbitration on issues when necessary. There is strong coordination and communication amongst the grant-recipient group, local leaders, and local government representatives. The project makes use of materials and supplies that can be maintained by the community, and the use of materials that will not harm the environment. APPLICATION AND SUBMISSION INFORMATION E.1 Address to Request Application Package Applicants can find the required application forms on the U.S. Embassy Kampala website at https://ug.usembassy.gov/embassy/kampala/grant-programs/?_ga=2.158558194.912728234.1709815691-399122090.1698829609 or on www.grants.gov under the announcement title Small Grants Ambassadors Special Self-Help Program, funding opportunity number DOS-KAM-AMBSSH-FY22. E.2 Content and Form of Application Submission Complete applications must include the following: Complete the SSH 2024 application (Annex A) Completed Budget package (Annex B). Includes: Detailed line-item budget. Budget Narrative; and Activity logical framework with project timeline. A copy of the organizations registration certificate, if available. A letter of approval for proposed project from the local development committee, tribal authority, and/or local town or district council. Original pro-forma invoices/quotations from the intended suppliers. Three quotes for each item are required. Download: Detailed NOFO: Ambassadors Special Self-Help Program 2024 Download: Budget Template: SSH 2024 BUDGET Download: Application Form: SSH2024-APPLICATION-FORM All application materials must be submitted in English. Please make a copy of your entire application for your own records. Submission Dates and Times Applications are due no later than 11:59 p.m. Eastern Africa Time (EAT), on June 4, 2024, and must be made electronically to [email protected]. Please submit the application package in Word and Excel format; do not submit as a PDF. APPLICATION REVIEW INFORMATION F.1 Criteria Only complete applications will be evaluated. The Proposal Review Committee will evaluate proposals according to several criteria, including: quality of project idea and impact on target group; community participation and contribution in the project design, implementation, and monitoring and evaluation; project outreach/impact (i.e. cost per beneficiary); feasibility of successful project implementation/impact (over a 1-year grant period); sustainability; and transparent and participatory beneficiary selection process. Organizational capacity and past performance will also be considered. F.2 Review and Selection Process The Small Grants Office strives to ensure each application receives a balanced evaluation by a Review Panel. The Small Grants Office will determine technical eligibility for all applications. Proposals that meet the evaluation criteria and move on to the next level will be informed of next steps in the application process. Non-eligible applicants will be notified that they are not being considered for funding. CONTACT INFORMATION For technical submission questions related to this solicitation, please contact the Small Grants Office at [email protected] or +256 (0)414 306444. Applications and additional guidelines are available at https://ug.usembassy.gov/embassy/kampala/grant-programs/?_ga=2.158558194.912728234.1709815691-399122090.1698829609 OTHER INFORMATION Applicants should be aware that Small Grants Office understands that some information contained in applications may be considered sensitive or proprietary and will make appropriate efforts to protect such information. Issuance of the NOFO and negotiation of applications does not constitute an award commitment on the part of the U.S. government. The Small Grants Office reserves the right to reduce, revise, or increase proposal budgets in accordance with the needs of the project evaluation requirements.

International Development
Independent school districts