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Grants for Small businesses - Federal

Explore 1,549 grant opportunities

Mapping Machine Learning to Physics (ML2P)
Contact for amount
U.S. Department of Defense
Federal

Application Deadline

Dec 9, 2025

Date Added

Sep 29, 2025

This grant provides funding to a diverse range of organizations, including businesses and research institutions, to develop energy-efficient machine learning technologies that can be applied in energy-constrained environments, particularly for national defense.

Science and Technology
Public and State controlled institutions of higher education
Imaging, Biomarkers and Digital Pathomics for the Early Detection of Premetastatic Cancer and Precancerous Lesions Associated with Lethal Phenotypes (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 5, 2025

Date Added

Apr 12, 2022

This grant provides funding for researchers and institutions to develop advanced imaging and biomarker technologies that improve the early detection of aggressive cancers and precancerous lesions, ultimately enhancing patient outcomes and clinical decision-making.

Education
State governments
KUH Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 - Independent Clinical Trial Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 4, 2024

Date Added

Mar 16, 2022

This grant provides funding to exceptional U.S.-based graduate students transitioning from predoctoral to postdoctoral research in kidney, urologic, or hematologic sciences, encouraging diverse talent to contribute to these fields.

Food and Nutrition
Public and State controlled institutions of higher education
Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)
$1,838,436
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 5, 2025

Date Added

Jun 21, 2022

This funding opportunity provides financial support for small businesses and researchers to develop innovative products and services aimed at preventing, diagnosing, and treating Alzheimer's disease and related dementias, ultimately improving care for affected individuals and their families.

Health
Small businesses
DoD Parkinsons Investigator-Initiated Research Award
$12,000,000
Department of Defense - Dept. of the Army -- U.S.AMRAA
Federal

Application Deadline

Aug 6, 2024

Date Added

May 8, 2024

The PRP IIRA supports highly rigorous, multidisciplinary, high-impact research projects that have the potential to make an important contribution to Parkinsons research. This award mechanism supports the full spectrum of research from basic science through clinical research.

Science and Technology
Nonprofits
DRL Global Support Program on Disability Inclusion Practices
$400,000
DOS-DRL (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

Jun 27, 2024

Date Added

May 2, 2024

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor announces an open competition for organizations interested in submitting applications for programs to bolster non-governmental organizations internal accessibility and inclusion policies and practices

International Development
Nonprofits
Building a Community of Practice for Women in Strategic Trade (WiST)
$641,225
DOS-ISN (Bureau of International Security-Nonproliferation)
Federal

Application Deadline

May 28, 2024

Date Added

Mar 27, 2024

To implement a project aimed at advancing U.S. foreign policy and national security priorities by supporting initiatives that make decision-making structures and processes in fragile, conflict, or crisis-affected contexts more reflective of and responsive to the needs and perspectives of partner states to ensure strategic trade control systems meet international standards and by engaging on bilateral, regional and multilateral levels with foreign governments to aid in the establishment of independent capabilities to regulate transfers of weapons of mass destruction, WMD-related items, conventional arms, and related dual-use items, and to detect, interdict, investigate, and prosecute illicit transfers of such items.

Law Justice and Legal Services
City or township governments
Information Mastery in Cognitive Warfare
$24,120,000
U.S. Department of Defense (Air Force -- Research Lab)
Federal

Application Deadline

Sep 6, 2025

Date Added

Aug 8, 2025

This funding opportunity provides financial support for a wide range of organizations to develop innovative research and tools aimed at enhancing national security through advancements in cognitive and information warfare strategies.

Science and Technology
For profit organizations other than small businesses
Innovations to Optimize HIV Prevention and Care Continuum Outcomes (R01 Clinical Trial Optional)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 9, 2025

Date Added

Jan 10, 2023

This funding opportunity supports research projects that develop innovative strategies to improve HIV prevention and treatment outcomes, particularly for marginalized populations, by addressing barriers and enhancing community engagement.

Health
State governments
Mitochondrial-associated Mechanisms of Neuropathological and Immunodeficient Aging in the Context of HIV and SUD (R01 Clinical Trials Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Mar 10, 2026

Date Added

Oct 1, 2024

This funding opportunity supports research projects that investigate how mitochondrial function affects brain health and immune aging in individuals living with HIV and substance use disorders, aiming to identify new therapeutic strategies.

Education
State governments
Resource-based Centers for Rheumatic Diseases Research
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 3, 2025

Date Added

May 28, 2025

This funding opportunity is designed to support the establishment of research centers that provide essential resources and infrastructure for advancing studies on rheumatic diseases, encouraging collaboration among researchers and institutions.

Health
State governments
Strengthening the HIV treatment and care program in Sierra Leone to accelerate progress to achieve epidemic control under the President's Emergency Plan for AIDS Relief (PEPFAR)
$12,000,000
U.S. Department of Health and Human Services (Centers for Disease Control-GHC)
Federal

Application Deadline

Feb 17, 2026

Date Added

Oct 17, 2025

This funding opportunity provides financial support to a wide range of organizations working to improve HIV treatment and care services in Sierra Leone, aiming to enhance healthcare delivery and strengthen local health systems.

Health
For profit organizations other than small businesses
Treating Hereditary Rare Diseases With In Vivo Precision Genetic Medicines
Contact for amount
U.S. Department of Health and Human Services (Advanced Research Projects Agency for Health)
Federal

Application Deadline

Dec 19, 2025

Date Added

Sep 29, 2025

This grant provides funding for multidisciplinary teams, including researchers, industry partners, and patient advocates, to develop innovative genetic therapies for rare hereditary diseases affecting millions of Americans, particularly children, by creating safe and effective one-time treatments.

Health
State governments
NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart, Lung, Blood, and Sleep Disorders and Diseases (R44 Clinical Trial Optional)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Nov 20, 2024

This grant provides funding to small U.S.-based businesses developing innovative technologies for heart, lung, blood, and sleep disorders, helping them bridge the gap between research and market readiness.

Health
Small businesses
Scaling-up and Maintaining Evidence-based Interventions to Maximize Impact on Cancer (SUMMIT) - Tobacco Use Treatment for Cancer Survivors (UG3/UH3 Clinical Trial Required)
$500,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Dec 6, 2024

Date Added

Oct 3, 2024

This funding opportunity supports research projects that develop and implement effective tobacco use treatment services for cancer survivors across diverse clinical settings, with a focus on equitable access and reducing health disparities.

Education
State governments
Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed)
$300,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 23, 2025

Date Added

Jul 18, 2024

This funding opportunity supports researchers and organizations in improving and sustaining software tools for biomedical and health-related research by adopting best practices and enhancing collaboration within the scientific community.

Education
State governments
Advanced Nuclear Energy Licensing Cost-Share Grant Program
$8,000,000
U.S. Department of Energy (Idaho Field Office)
Federal

Application Deadline

Apr 8, 2025

Date Added

Jan 9, 2025

This funding opportunity provides financial assistance to U.S. entities involved in advanced nuclear energy projects to help cover regulatory review costs associated with licensing advanced reactors and related facilities.

Energy
County governments
ROSES 2024: C.16 Laboratory Analysis of Returned Samples
$2,600,000
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Mar 28, 2025

Date Added

Feb 15, 2024

This grant provides funding for researchers and organizations to conduct laboratory analysis of samples returned from space missions, supporting advancements in space and Earth sciences.

Science and Technology
Nonprofits
Engineering Improved Stem Cell-Derived Islet Cells for Replacement Therapies
$3,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 1, 2025

Date Added

Jun 14, 2025

This funding opportunity supports research to improve stem cell-derived islet cells for transplantation therapies, targeting interdisciplinary collaborations among scientists and institutions focused on diabetes and cell biology.

Health
State governments
Strategic Technology Office (STO) Office-wide
Contact for amount
U.S. Department of Defense (DARPA - Strategic Technology Office)
Federal

Application Deadline

Nov 15, 2024

Date Added

Nov 4, 2024

This grant invites academic institutions, private companies, and nonprofit organizations to propose innovative research projects that advance national security and defense technologies, with a focus on disruptive solutions across various domains.

Science and Technology
Public and State controlled institutions of higher education