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Grants for Small businesses - Federal

Explore 1,532 grant opportunities

NINDS Exploratory Clinical Trials for Small Business (R41/R42 Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Nov 27, 2023

This funding opportunity provides financial support for small businesses to conduct exploratory clinical trials focused on neurological disorders, including the development of drugs, devices, and therapies.

Health
Small businesses
BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trial Optional)
$8,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

May 23, 2025

Date Added

May 31, 2024

This funding opportunity supports interdisciplinary teams in developing innovative tools to measure and analyze human behavior in real-world settings, integrating neural and environmental data to advance our understanding of brain function and behavior.

Education
State governments
Notice of Intent to Publish a Funding Opportunity Announcement for Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)
$2,000,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 17, 2025

Date Added

Oct 25, 2024

This funding opportunity supports research projects that utilize existing datasets to advance understanding of substance use disorders, targeting a wide range of eligible applicants including educational institutions, government entities, and nonprofits.

Health
State governments
DoD Military Burn, Discovery Award
$200,000
U.S. Department of Defense (Dept. of the Army -- U.S.AMRAA)
Federal

Application Deadline

Sep 8, 2025

Date Added

May 2, 2025

This funding opportunity supports innovative research projects aimed at improving burn care for military personnel, particularly in combat situations, by addressing unique medical challenges and enhancing treatment methods.

Science and Technology
Nonprofits
Notice of Intent to Publish a Funding Opportunity Announcement for Academic Career Excellence (ACE) Award (K32 - Independent Clinical Trial Required)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 12, 2025

Date Added

Dec 27, 2024

This funding opportunity provides financial support to early-stage postdoctoral researchers dedicated to advancing their careers in cancer research through enhanced training and mentorship.

Health
State governments
Reliable Ore Characterization with Keystone Sensing SBIR/STTR (ROCKS SBIR/STTR)
$4,505,859
U.S. Department of Energy (Advanced Research Projects Agency Energy )
Federal

Application Deadline

Sep 25, 2025

Date Added

Aug 26, 2025

This funding opportunity provides financial support to U.S. small businesses developing innovative technologies for faster and more cost-effective mineral resource evaluation, particularly for rare earth elements and critical minerals essential for clean energy and advanced technologies.

Natural Resources
Small businesses
Seeking Products to Address Social Needs impacting Substance Use Disorders (SUD) (R43/R44 Clinical Trial Optional)
$295,924
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Sep 28, 2023

This funding opportunity is designed to support small businesses in developing innovative technologies that address social needs impacting individuals with substance use disorders, excluding alcohol, to improve access to care and enhance recovery outcomes.

Education
Small businesses
NSF/CASIS Transport Phenomena Research at the International Space Station to Benefit Life on Earth
$3,600,000
National Aeronautics & Space Administration (National Science Foundation)
Federal

Application Deadline

Apr 10, 2025

Date Added

Jan 2, 2025

This funding opportunity supports U.S.-based organizations and educational institutions in conducting innovative research on fluid dynamics, materials, and manufacturing processes in the unique microgravity environment of the International Space Station, with the goal of benefiting life on Earth.

Science and Technology
For profit organizations other than small businesses
Discovery and Development of Natural Products for Cancer Interception and Prevention (UG3/UH3 Clinical Trial Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 13, 2025

Date Added

Oct 2, 2024

This funding opportunity supports U.S.-based researchers and organizations in discovering and developing natural products as potential agents for cancer prevention, focusing on safe and effective compounds.

Education
State governments
FY24 Vehicle Technologies Office Batteries and Electrification Funding Opportunity Announcement
Contact for amount
U.S. Department of Energy
Federal

Application Deadline

Not specified

Date Added

Jul 17, 2024

This funding opportunity supports innovative projects aimed at advancing electric vehicle technology and battery development, particularly for teams that include diverse stakeholders and focus on safety, cost reduction, and environmental justice.

Environment
Nonprofits
NIMHD Exploratory/Developmental Research Grant Program (R21 - Clinical Trial Optional)
$200,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 16, 2025

Date Added

Feb 1, 2023

This funding opportunity supports innovative research projects aimed at improving health outcomes and reducing disparities for minority populations in the U.S. through short-term studies and pilot interventions.

Health
State governments
Limited Competition: Research Centers in Minority Institutions (RCMI) Coordinating Center (U24 - Clinical Trial Optional)
$3,500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 25, 2025

Date Added

Dec 10, 2024

This funding opportunity provides financial support to U.S. institutions focused on improving minority health and reducing health disparities by enhancing research capacity, fostering investigator development, and promoting community engagement.

Health
State governments
ROSES 2024: B.10 Heliophysics Flight Opportunities Studies
Contact for amount
National Aeronautics & Space Administration (NASA Headquarters)
Federal

Application Deadline

Aug 28, 2024

Date Added

Feb 15, 2024

Proposers must retrieve the instructions document (zip file) associated with the application package for this opportunity as there is at least one required form that must be attached to the submitted proposal package. The National Aeronautics and Space Administration (NASA) Science Mission Directorate (SMD) released its annual omnibus Research Announcement (NRA), Research Opportunities in Space and Earth Sciences (ROSES) 2024 (OMB Approval Number 2700-0092, CFDA Number 43.001) on February 14, 2024. In this case "omnibus" means that this NRA has many individual program elements, each with its own due dates and topics. All together these cover the wide range of basic and applied supporting research and technology in space and Earth sciences supported by SMD. Awards will be made as grants, cooperative agreements, contracts, and inter- or intra-agency transfers, depending on the nature of the work proposed, the proposing organization, and/or program requirements. However, most extramural research awards deriving from ROSES will be grants, and many program elements of ROSES specifically exclude contracts, because contracts would not be appropriate for the nature of the work solicited. The typical period of performance for an award is three years, but some programs may allow up to five years and others specify shorter periods. In most cases, organizations of every type, Government and private, for profit and not-for-profit, domestic and foreign (with some caveats), may submit proposals without restriction on teaming arrangements. Tables listing the program elements and due dates (Tables 2 and 3), a table that provides a very top level summary of proposal contents (Table 1), and the full text of the ROSES-2024 "Summary of Solicitation", may all be found NSPIRES at http://solicitation.nasaprs.com/ROSES2024. This synopsis is associated with one of the individual program elements within ROSES, but this is a generic summary that is posted for all ROSES elements. For specific information on this particular program element download and read the PDF of the text of this program element by going to Tables 2 or 3 of this NRA at http://solicitation.nasaprs.com/ROSES2024table2 and http://solicitation.nasaprs.com/ROSES2024table3, respectively, click the title of the program element of interest, a hypertext link will take you to a page for that particular program element. On that page, on the right side under "Announcement Documents" the link on the bottom will be to the PDF of the text of the call for proposals. For example, if one were interested in The Lunar Data Analysis Program (NNH24ZDA001N-LDAP) one would follow the link to the NSPIRES page for that program element and then to read the text of the call one would click on C.8 Lunar Data Analysis Program (.pdf) to download the text of the call. If one wanted to set it into the context of the goals, objectives and know the default rules for all elements within Appendix C, the planetary science division, one might download and read C.1 Planetary Science Research Program Overview (.pdf) from that same page. While the letters and numbers are different for each element within ROSES (A.12, B.7, etc.) the basic configuration is always the same, e.g., the letter indicates the Science Division (A is Earth Science, B is Heliophysics etc.) and whatever the letter, #1 is always the division overview. Frequently asked questions for ROSES are posted at http://science.nasa.gov/researchers/sara/faqs. Questions concerning general ROSES-2024 policies and procedures may be directed to Max Bernstein, Lead for Research, Science Mission Directorate, at [email protected], but technical questions concerning specific program elements should be directed to the point(s) of contact for that particular element, who may be found either at the end of the individual program element in the summary table of key information or on the web list of topics and points of contact at: http://science.nasa.gov/researchers/sara/program-officers-list. Not all program elements are known at the time of the release of ROSES. To be informed of new program elements or amendments to this NRA, proposers may subscribe to: (1) The SMD mailing lists (by logging in at http://nspires.nasaprs.com and checking the appropriate boxes under "Account Management" and "Email Subscriptions"), (2) The ROSES-2024 blog feed for amendments, clarifications, and corrections to at https://science.nasa.gov/researchers/solicitations/roses-2024/, and (3) The ROSES-2024 due date Google calendars (one for each science division). Instructions are at https://science.nasa.gov/researchers/sara/library-and-useful-links (link from the words due date calendar).

Science and Technology
Nonprofits
Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Nov 17, 2025

Date Added

Apr 27, 2024

This funding opportunity supports new entrepreneurs in small businesses by providing resources for their career development and research efforts, helping them grow their skills while advancing innovative health-related technologies.

Education
Small businesses
Ensuring Research Integrity - Program Development and Evaluation Program (PDE)
$75,000
U.S. Department of Health & Human Services (Office of the Assistant Secretary for Health)
Federal

Application Deadline

Jul 30, 2025

Date Added

Jul 18, 2025

This funding opportunity supports institutions and individuals in developing innovative programs and tools to promote research integrity and prevent misconduct in biomedical and behavioral research.

Science and Technology
Individuals
Partnerships with MCC Program
$750,000
Millennium Challenge Corporation
Federal

Application Deadline

Aug 26, 2025

Date Added

Aug 27, 2025

This program provides funding for innovative partnerships that help reduce poverty through economic growth in developing countries, focusing on initiatives like infrastructure resilience and women's entrepreneurship.

International Development
Nonprofits
Molecular Mechanisms of Combination Adjuvants (MMCA) (R01 Clinical Trial Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 10, 2025

Date Added

Jan 14, 2025

This funding opportunity supports researchers at various institutions to investigate how combining vaccine adjuvants can improve immune responses, ultimately leading to better vaccine designs for different diseases.

Health
State governments
Elucidating Mechanisms Associated with HIV Related Co-Morbidities in Populations Experiencing Health Disparities (R01 - Clinical Trials Not Allowed)
$500,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Feb 24, 2025

Date Added

Mar 2, 2024

This grant provides funding for research aimed at understanding the factors that contribute to health disparities in HIV and aging among racial and ethnic minorities, low-income populations, and other underserved groups, focusing on how multiple health conditions affect their overall well-being and quality of life.

Food and Nutrition
State governments
DRL Increase Access to Due Process in Uzbekistan
$500,000
DOS-DRL (Bureau of Democracy Human Rights and Labor)
Federal

Application Deadline

May 10, 2024

Date Added

Mar 12, 2024

The U.S. Department of State, Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for organizations interested in submitting applications for projects that increase transparency in citizensโ€™ rights to due process. Uzbekistanโ€™s constitution and law prohibit arbitrary arrest and detention and provide for the right of any person to challenge the lawfulness of his or her arrest or detention in court. Additionally, by law a judge must review any decision to arrest accused individuals or suspects. Judges grant arrest warrants in most cases. Detention without formal charges is limited to 48 hours, although a prosecutors may request that a judge extend detention an additional 48 hours, after which the person must be charged or released. Judges typically grant such requests, and the judge who issues such an extension is often the same one who presided over the trial, which creates incentives to cover up violations. The arresting authority is required to notify a relative of a detainee of the detention and to question the detainee within 24 hours of arrest. Visibility into arrest procedures and treatment of detainees is low, even for family members of detainees and Uzbekistani civil society engaged on the issue of due process. 2 Through this award, DRL aims to support the safe, secure, and professional collection of credible information on political detainees by Uzbekistani media, Civil Society Organizations, (CSOs) and human rights defenders, for human rights reporting and advocacy and to improve the capacity of Uzbekistani CSOs to advocate for transparency and improved conditions in detention facilities.

International Development
Nonprofits
Scientific Feasibility (SciFy)
Contact for amount
U.S. Department of Defense (DARPA - Information Innovation Office)
Federal

Application Deadline

Aug 25, 2024

Date Added

Mar 2, 2024

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative and revolutionary computational approaches that measure the feasibility of technical claims to enable accurate assessments of scientific content. This publication constitutes a Broad Agency Announcement (BAA) as contemplated in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016 and 2 C.F.R. ยง 200.203. Any resultant award negotiations will follow all pertinent laws and regulations, and any negotiations and/or awards for procurement contracts will use procedures under FAR 15.4, Contract Pricing, as specified in the BAA. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in the following areas of interest: feasibility assessment of scientific content and testing and evaluation of feasibility assessment methods. Proposed research should investigate innovative approaches that enable revolutionary advances in science or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice. Multiple awards are anticipated. The amount of resources made available under this BAA will depend on the quality of the proposals received and the availability of funds.

Science and Technology
City or township governments