Grants for Small businesses - Federal

This funding opportunity supports researchers and organizations developing innovative prediction models for early detection of Alzheimer's Disease and related dementias, particularly focusing on data from underserved communities to address health disparities.

This grant provides financial and technical support to conservation partners, including state and Tribal agencies and nonprofits, for projects that restore and protect coastal fish and wildlife habitats, focusing on priority species and ecosystems.

This funding opportunity provides $8 million to support U.S. organizations in developing innovative energy storage technologies that improve manufacturability and reduce production costs, with a focus on achieving commercialization and enhancing the energy storage industry.

This funding opportunity is designed for small businesses to develop innovative drone swarm technology that enhances the U.S. Army's capabilities for efficient and safe river crossings in challenging environments.

This funding opportunity supports universities, research institutions, and non-profit organizations in conducting innovative research in measurement science to advance fundamental measurement methods and enhance our understanding of physics.

The U.S. Department of State Bureau of Democracy, Human Rights, and Labor (DRL) announces an open competition for an evaluation project that contributes to building a portfolio of evidence regarding inclusive human rights in Ukraine. In support of this goal, DRL seeks to promote the use of sound data and generate findings on what works, for whom, and why in democracy and human rights programming abroad. Projects should support the following objective: the rights of marginalized, underserved, and at-risk individuals in Ukraine are recognized and respected within a democracy, rights, and good governance framework.

This funding opportunity supports research projects that utilize existing cancer epidemiology cohort data to investigate important questions about cancer prevention, treatment, and survivorship, particularly for underserved populations and rare cancers.

The National Institute of Diabetes and Digestive and Kidney Disorders (NIDDK) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for the TrialNet Coordinating Center (TNCC). The TrialNet network identifies people with type 1 diabetes (T1D) at stages before and after onset of clinical symptoms and enrolls them in trials and studies aimed at prevention of progression to clinical disease and preservation of insulin production. The TNCC participates in ongoing studies and intervention trials as well as the design and conduct of new studies and intervention trials. The TNCC will: (1) support a wide range of research projects in varying stages of development, implementation and completion, and (2) provide data and sample management, including standardized acquisition, quality control, dissemination and public accessibility. The TNCC will be responsible for network administration and operations, including the evaluation, selection, and funding (through subcontracts) of Clinical Centers and central support units (such as laboratories) necessary for the conduct of TrialNets clinical studies. The TNCC PD/PI will be a voting member of the TrialNet Executive and Steering Committees, contributing to network leadership. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in Spring 2024 with an expected application due date in Summer 2024. This NOFO will utilize the U01 activity code. Details of the planned NOFO are provided below.

This funding opportunity provides up to $1 million to a wide range of organizations to develop a centralized resource for exploring and analyzing single-cell genomics data from the human brain, enhancing research on brain health and disease.

This funding opportunity supports researchers with a strong background in promoting diversity, equity, inclusion, and accessibility in biomedical fields, enabling them to conduct scientific research while advancing DEIA initiatives within the academic and scientific communities.

The FY24 RCRP RCDA supports the development of clinical or preclinical data sets and research resources that advance the field of rare cancers research and ultimately improve outcomes for individuals with rare cancers. Major gaps in patient care of rare cancers include lack of communication and dissemination strategies for rare cancers research and clinical findings within communities; lack of therapeutics and mechanistic studies to inform treatment development; lack of research and clinical resources, including patient tissues, cell, and tumor models; and lack of infrastructure for sharing data and other resources.The intent of this funding opportunity is to develop research platforms that can share resources and knowledge pertaining to available preclinical or clinical research models, molecular pathways, and therapeutic approaches to facilitate collaboration and information sharing among stakeholders such as researchers, patients, caregivers, clinicians, and other members of the rare cancers community.Clinical or preclinical datasets should strive to integrate or develop the following research resources. This list is not all-inclusive: Building and sharing rare tumor biospecimen repository with clinical annotation Databases/banks for centralizing and sharing data for patient registries that can be accessed globally Centralizing and sharing research models and molecular data related to genomics/ transcriptomics/immune profiling/proteomics/metabolomics/methylomics/bioinformatics Generating a data/reagent/model exchange program where researchers can list resources that they are willing to share and are tagged with indications that may be relevant Platform to enable or leverage longitudinal studies of disease natural history and treatment response Development of novel methods and systems for collection, sharing, and analysis of data or biospecimensApplicants should include a well-formulated project design based on a strong scientific rationale and clearly articulate how the proposed resource platform or community development addresses an unmet need in rare cancers research. Applicants should explain the advantage of their approach to developing resources or community versus standard methodologies, techniques, or scopes. A clear plan for collaboration and data sharing needs to be demonstrated. It is critical to demonstrate how the outcome of the proposed project can benefit type(s) or sub-type(s) of rare cancers. It is encouraged for the research platform/resource to have an effect on multiple types or sub-types of rare cancers.Key Elements of the Resource and Community Development Award are as follows: Impact: Outcomes of the RCDA must have potential for major impact on an unmet need in rare cancers research. A resource, as developed in the proposed research, should aim forDOD FY24 Rare Cancers Resource and Community Development Award 5long-term anticipated advantages toward greatly improving outcomes for people with rare cancers. Patient Advocate Partnership: Applications to the RCDA funding opportunity are required to include patient advocates who are involved with patient advocacy organization(s). The research team must include at least two rare cancers patient advocates who will be early and integral partners throughout the planning and implementation of the research project. Patient advocates should be involved in the development of the research question, project design, oversight, and evaluation, as well as other significant aspects of the proposed project. Interactions with other team members should be well integrated and ongoing, and not limited to attending seminars and semi-annual meetings. The patient advocates must be individuals who have been directly impacted by a rare cancer either by being diagnosed themselves or as a caretaker/family member of a patient, and they should be active in a cancer advocacy organization or within a support group focused on their rare cancer. Their role should be focused on providing objective input on the research and its potential impact for individuals with or at risk for a rare cancer. The patient advocates should have a high level of understanding of current rare cancers research. Preliminary Data: Due to the developmental nature of this award, preliminary data are not required but may be included, if available, to address the feasibility of the resource to be developed. Whether or not preliminary data are included, applications must apply solid scientific rationale and logical reasoning based on existing knowledge to the development of the proposed product. Clinical Research: Research involving human subject use is permitted under this mechanism but is restricted to studies without clinical trials. Clinical trials will not be supported. Applications focused on clinical research should demonstrate how the study will leverage clinical information to address knowledge gaps in the development of platforms that can be utilized for sharing data and tissue, the development of clinical annotation datasets, process development, and/or infrastructure development. Applied Research: Preclinical studies utilizing or creating animal models to further research into rare cancers may be supported by this funding opportunity. The RCDA is intended to support projects that will have the potential to move beyond the realm of basic research, with results that may impact clinical research or patient outcomes. Community Building: A plan describing how the rare cancers stakeholder community will be built/enhanced and the communitys involvement with developing the resource platform is required. It is also important to justify how the community is essential for the development and sustainment of the resource platform. Dissemination: A Dissemination Plan is required. The plan should describe the means by which the fully developed resource platform will be made easily available to the scientific and/or clinical community. Dissemination of resource platform will play a major role by not only educating the rare cancer community about the recent progress, but also help to develop an informational network.DOD FY24 Rare Cancers Resource and Community Development Award 6 Sustainment: A plan that outlines the sustainability of the resource in the future is required. The plan should detail the types of rare cancers that are less studied in the collaborations and the resources to be gathered, annotated, and sustained. Additional expansion and feasibility plans should be included. It is important to demonstrate how the outcomes of the current award will be continued and eventually will help the rare care cancer community, beyond the award period.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 RCRP priorities.Collaborations between researchers at military or Veteran institutions and non-military institutions are strongly encouraged. These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the partners bring to the research effort, ultimately advancing cancer research that is of significance to the Warfighter, military Families, and the American public.Innovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in womens health outcomes and/or advancing knowledge for women's health.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.

This funding opportunity provides financial support for innovative companies developing new solar technologies to boost domestic manufacturing and reduce reliance on imports, with a focus on enhancing energy security and promoting economic growth.

This funding opportunity supports research projects aimed at reducing disparities in maternal health outcomes among vulnerable populations in the U.S. by investigating healthcare system and clinician factors.

This grant provides funding opportunities for a wide range of organizations, including state governments, universities, and nonprofits, to develop and implement innovative projects focused on preventing injuries and improving community health.

This funding opportunity supports U.S.-based researchers and institutions in various physics subfields to conduct innovative experimental and theoretical projects that advance scientific knowledge and promote workforce diversity.

The "DoD Multiple Sclerosis, Exploration - Hypothesis Development Award" is a grant that supports the exploration of innovative, high-risk concepts in MS research, with the aim of laying the groundwork for future scientific investigation, and it particularly encourages applications from new investigators in the early stages of their careers.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development intends to publish a Notice of Funding Opportunity (NOFO) to invite applications to establish integrated and collaborative Stillbirth Research Centers, as part of a new Stillbirth Research Consortium. The Centers will support cutting-edge basic, translational, clinical, and/or data sciences research and generate knowledge to fuel advancement of stillbirth-relevant research in the United States, with a particular emphasis on approaches that utilize an equity lens to identify ways to decrease the incidence of stillbirth in vulnerable populations. A Data Coordinating Center (described in the companion announcement NOT-HD-24-010) will support the work of the research projects funded under the Stillbirth Research Consortium. This Notice is being provided to allow potential applicants additional time to develop meaningful collaborations, interdisciplinary teams, and responsive applications. International collaboration is encouraged and allowable. The NOFO is expected to be published in Summer 2024 with an expected application due date in Winter 2024. This NOFO will utilize the UG1 activity code. Details of the planned NOFO are provided below.

This funding opportunity supports U.S.-based organizations in exploring groundbreaking aerospace concepts that could transform NASA's missions or create new ones through innovative technological advancements.

The U.S. Embassy Djibouti is pleased to announce that funding is available for reforestation efforts in Djibouti City. This notice of funding opportunity outlines the procedures for submitting requests for funding. Please carefully follow all instructions below. Purpose of the Grant: U.S. Embassy Djibouti invites proposals from local organizations to combat climate change and urban heat in Djibouti City through reforestation and sustainable landscaping. Djibouti is one of the hottest countries on the planet and increasingly vulnerable to climate change. Djibouti has suffered from chronic drought, which has worsened over the years due to climate change. Average annual temperatures oscillate between 23C and 40C but can easily reach 50C during the months of June, July, and August. Djibouti is a highly urbanized country with more than 70 percent of the population living in the capital city, Djibouti City. In the capital, the level of sunshine and temperatures remain well above the national average. The effects of climate change coupled with rapid urbanization have contributed to the destruction of vegetation cover in Djibouti City. Reforestation has been proven to reduce the mean temperature in cities by 0.4C. Climate change, rapid urbanization, deforestation, and aging and inadequate drainage infrastructure has increased the risk of severe flooding when it does rain. The variability and intensity of rainfall, combined with urbanization, increase the risk of flooding. In April 2024, severe flooding from a few hours of rain trapped communities and destroyed roads and bridges in the city. The Mayor of Djibouti has set a Green City vision. Part of this effort is to increase reforestation, climate smart practices, and reduce urban heat. This project will support sustainable reforestation efforts in Djibouti City. Priority Program Areas: Funding will support proposals that directly respond to extreme heat and climate response efforts in Djibouti City. As the effects of climate change push rural communities to the city, the city needs to adapt and mitigate the effects of extreme heat. This project will advance broader climate change mitigation efforts being led by the Government of Djibouti. The projects key objectives are to: 1. Provide training on sustainable landscaping and tree placement to mitigate urban flooding and extreme heat. 2. Increase reforestation in Djibouti City.

This grant provides funding for U.S.-based researchers to explore innovative tissue engineering and mechanobiology solutions using the unique microgravity environment of the International Space Station, with the goal of improving health outcomes on Earth.