Grants for State governments - Federal

Modified release (MR) oral drug products are considered to have a high risk for alcohol dose dumping (ADD) because they contain large quantities of drug(s), designed to release over a prolonged period of time. Accidental exposure of these products to alcohol can result in the relatively rapid release of large quantities of drug with severe side effects, including death. To mitigate this risk, the FDA recommends conducting an in vitro alcohol dose dumping assessment in 0%, 5%, 20%, and 40% alcoholic dissolution media for all prospective generic versions of MR oral drug products. To date, ADD assessments have not been harmonized globally. For instance, the U.S. FDA recommends testing up to 40% alcoholic media while the European Medicines Agency recommends testing up to 20% alcoholic media. This type of difference can present a challenge for formulators designing products for multiple markets, as historical data has shown release from MR oral products do not always follow a linear response (either increasing or decreasing) to increasing alcohol concentrations. In addition, interpretation of an ADD assessment may be limited by the inability of the test to predict in vivo behavior. The purpose of this research is to develop tools that 1) facilitate the development of MR generic drug products that have a low potential for ADD, 2) support regulatory decision making during the assessment of such products, and 3) provide evidence that enables FDA to develop more specific recommendations for efficiently demonstrating a low or comparative potential of alcohol dose dumping for MR oral drug products containing high risk drugs.

This funding opportunity supports small-scale brain imaging research related to substance use and addiction, aimed at helping both new and established researchers develop innovative studies that enhance our understanding of neurobiological mechanisms in these areas.

This grant provides funding for academic training programs to develop skilled professionals in vocational rehabilitation, specifically targeting individuals who will support people with disabilities.

This program provides funding to state agencies and local governments to improve parks and recreational facilities in urban areas with limited access to outdoor spaces, focusing on community engagement and environmental sustainability.

This funding opportunity supports research teams from various sectors to explore how sex differences influence the biological factors related to Alzheimer’s disease and its treatment, aiming to enhance understanding and improve precision medicine approaches.

This funding opportunity supports collaborative research projects aimed at understanding and treating infectious and immune-related diseases, open to a wide range of organizations including universities, nonprofits, and government entities.

This grant provides funding for innovative and high-risk technology development projects in biomedical research that are in the early exploratory stages and have not yet been proven feasible.

This funding opportunity provides financial support for research projects that aim to improve healthcare access and outcomes for individuals with disabilities by addressing the barriers they face in receiving necessary services.

The U.S. Department of Energys (DOE) Office of Energy Efficiency and Renewable Energy (EERE) Building Technologies Office (BTO) is issuing this Funding Opportunity Announcement (FOA) titled Bipartisan Infrastructure Law (BIL): Resilient and Efficient Codes Implementation (RECI). The current FOA represents the second installment in the RECI initiative, which maintains the same broad format, flexibility, and crosscutting areas of interest, while emphasizing and prioritizing specific gaps, needs, and opportunities to support building energy codes identified as focal points through the first RECI FOA and continued stakeholder engagement. The activities to be funded under the FOA support the BIL, as well as a broader government-wide approach to advance building codes and support their successful implementation. The primary focus centers around updating to more efficient building energy codes that save money for American homes and businesses, reduce greenhouse gas (GHG) emissions, and encourage more resilient buildings. This FOA includes one topic area broadly focused on the cost-effective implementation of updated energy codes.

This grant provides funding for innovative and high-risk research projects in biomedical, behavioral, or clinical fields, aimed at early-stage ideas that could lead to significant advancements.

Department of the Interior - Bureau of Land Management Arizona Threatened and Endangered Species Program. Electronically submitted applications must be submitted no later than 5:00 p.m., MDT, on the listed application due dates. Applications will be reviewed, rated, ranked and selected by the following rounds: Open from February 16, 2024, through May 17, 2024 Round One – Applications Due: April 15, 2024, 5:00 PM MDT. Round Two – Applications Due: May 17, 2024, 5:00 PM MDT. Applications must be submitted in English.Extensions to NOFO close dates will be unallowed, except in extenuating circumstances.

This funding opportunity supports researchers in discovering and validating new targets for developing safe and effective pain treatments with minimal side effects and low addiction risk.

This funding opportunity provides financial support to rural healthcare organizations in the Delta region to improve service delivery, enhance sustainability, and expand access to care through specific projects.

This funding opportunity provides financial support to designated regional consortia that include educational institutions, government entities, and industry partners to advance critical technologies and foster economic growth in their areas.

The BLM Arizona Cultural Heritage Partnership Program (CHPP) supports projects advancing the Department of Interior's priorities, including addressing the climate crisis, restoring balance on public lands, advancing environmental justice, and investing in a clean energy future. Projects should focus on public archaeology education, the development of educational programs, repatriation of Native American remains, and cultural resource inventory. Eligible applicants include higher education institutions, non-profits, state and local governments, and Indian tribal governments. The program aims to support projects that use science, data, and traditional knowledge to enhance economic opportunities for communities of color, low-income families, and rural and indigenous communities.

This funding opportunity provides financial support to state governments and U.S. territories to improve access to HIV care and treatment for low-income individuals living with HIV.

Workforce Innovation and Opportunity Act (WIOA) Workforce Information Grants Allotments for Program Year (PY) 2024. States should e-mail all submission questions to Janice Sheelor, Grants Management Specialist, at [email protected]. The email must reference the specific Funding Opportunity Number, and include a contact name, email address, and phone number.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRCs). These Centers promote collaborative basic, translational, and clinical research and provide important resources that can be used by the national muscular dystrophy research community. A goal of this Centers program is to support important and innovative research in the muscular dystrophies that is best pursued through an interdisciplinary and collaborative center environment and projects that may not be as effective if supported by "stand-alone" research project grants. The Centers also provide outstanding environments for the training of new scientists electing to pursue careers conducting research in high priority areas of muscular dystrophy. Finally, Center investigators are expected to engage the patient and advocacy communities in conversations to increase awareness of research, encourage patient participation in research, and incorporate the perspectives of these communities in the conduct of patient-centered research.

The DoD Reconstructive Transplant, Idea Discovery Award is a funding opportunity aimed at supporting innovative, high-risk/high-reward research projects related to reconstructive transplant, with a focus on generating robust data, addressing military health care needs, advancing women's health research, and adhering to rigorous experimental design, with a total budget not exceeding $500,000.

This Funding Opportunity Announcement (FOA) will support extramural research to investigate and mitigate challenges facing clinical assay development and subsequent analytical validation due to preanalytical variability in tumor tissue biopsies, blood biospecimens utilized as liquid biopsies", or other biospecimens as described in this FOA. Extramural research funded under this FOA may include investigations of preanalytical variability associated with the procurement and study of small biopsies (core biopsies, small excision samples), blood utilized for "liquid biopsies", tissue swabs, tissue secretions, pleural and esophageal aspirates, feces, or bodily fluids like sweat, urine, CSF, breast milk and saliva. Investigator-designed experiments will explore how different biospecimen preanalytical conditions affect emerging and clinically relevant biomarkers quantified by a variety of testing platforms. The results from this research program will improve the understanding of how analytical quantification of clinically relevant biomarkers is affected by variation in biospecimen collection, processing, and storage procedures. The overall goal is to expedite biomarker clinical assay development through evidence-based standardization of biopsy handling practices.