Federal Health Grants

This funding opportunity supports early-stage researchers and those new to Alzheimer's Disease and related dementias research, providing resources to develop innovative pilot projects aimed at improving prevention, diagnosis, treatment, and care strategies.

This funding opportunity supports diverse institutions and researchers in conducting innovative research to promote health equity and improve health outcomes for all individuals, particularly by addressing social determinants of health and eliminating health disparities.

The National Institutes of Health (NIH) Office of Data Science Strategy (ODSS), with other NIH Institutes and Centers (ICs), intends to promote an initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for established biomedical data repositories or knowledgebases. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NIH intends to continue the Database and Knowledgebase program beyond the January 25, 2023, receipt date of the current FOAs (PAR-23-078 and PAR-23-079). This new FOA will support established biomedical data repositories and knowledgebases. This Notice of Intent to Publish (NOITP) is being provided to allow potential applicants time to develop meaningful community engagement, collaborations, and NIH consultations to submit applications for responsive data repositories and knowledgebases as trans-NIH data resources. The FOA is expected to be published in Spring 2023 with an expected application due date in Fall, 2023. This FOA will utilize the U24 activity code. Details of the planned FOAs are provided below.

Reissue of RFA-MH-22-115 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application.

This funding opportunity supports institutions that have successfully completed an initial phase of a biomedical research program, enabling them to further develop research capabilities and enhance the careers of early-stage investigators.

This funding opportunity supports researchers in planning high-risk, multi-center clinical studies focused on kidney, digestive, diabetes, and metabolic disorders, helping them develop essential protocols and administrative frameworks before conducting the actual trials.

This funding opportunity supports research to improve cancer care and outcomes for sexual and gender minority survivors by addressing their unique challenges and engaging community partners in the process.

This grant provides funding for researchers to evaluate community and societal programs aimed at preventing adverse childhood experiences and addressing social and health inequities.

This grant provides funding to support postdoctoral researchers from underrepresented backgrounds in transitioning to independent cancer research roles, with a focus on clinical trials and addressing cancer health disparities.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage pilot and/or feasibility research in the following areas: 1) the development and pilot testing of new or adapted interventions to prevent or delay the initiation of substance use and/or the progression from use to misuse or disorder and 2) pre-trial feasibility and acceptability testing of services and service system research relevant to the prevention of substance use. In addition to the prevention of substance use, misuse and disorder, other outcomes of interest for the research supported through FOA include a reduction in negative sequalae such as deaths related to impaired driving, suicidal behavior (e.g., nonfatal and fatal attempts), and drug- or alcohol-related acquisition or transmission of HIV infection and viral hepatitis among diverse populations and settings.

This grant provides funding to institutions and organizations for establishing a centralized data coordination center that will manage and share research data on how socioenvironmental factors influence neurocognitive development and addiction risk.

This funding opportunity supports multi-site clinical trials for innovative treatments and interventions aimed at preventing or alleviating symptoms of Alzheimer's disease and related dementias, inviting applications from a diverse range of organizations and institutions.

This funding opportunity supports innovative research projects aimed at developing tools and treatments for diagnosing and mitigating injuries from radiation exposure during public health emergencies.

This funding opportunity announcement (FOA) encourages innovative research to develop, characterize, and improve animal models, biological materials, and novel technologies to better understand human health and disease. This FOA also seeks projects aimed at improving the diagnosis and control of diseases that interfere with animal use for biomedical research. The proposed project must have broad application to multiple NIH Institutes or Centers (ICs) to align with the Office of Research Infrastructure Programs (ORIP) trans-NIH mission. The proposed studies must explore multiple body systems or evaluate diseases that impact multiple body systems. Applications that develop models focused on a specific disease or area of research, or only propose studies primarily relevant to a single NIH IC will be considered not acceptable to this FOA.

This funding opportunity supports new entrepreneurs in small businesses by providing resources for their career development and research efforts, helping them to grow their skills in technology development and healthcare delivery.

This funding opportunity supports early-career clinical researchers in the U.S. to develop expertise in implementation science for substance use prevention and treatment through mentored clinical trials addressing the overdose crisis.

The "Single Source: NCI National Clinical Trials Network - Canadian Collaborating Clinical Trials Network" grant is a $3.8 million funding opportunity from the National Institutes of Health, specifically for Queen’s University at Kingston, to support its collaboration with the U.S. in conducting large-scale, multi-site clinical trials for innovative cancer treatments, while ensuring regulatory compliance and efficient data management.

The "Development and Validation of Human Cellular Models for Alzheimer's Disease-Related Dementias (ADRD)" grant aims to fund the creation and testing of new, complex human cell models that accurately represent Alzheimer's and related dementias, with the goal of improving our understanding of these diseases and aiding in the development of potential therapies.

This grant provides funding for educational programs that improve the skills and knowledge of researchers analyzing large, complex datasets related to brain function, behavior, and social factors affecting health outcomes.

This funding opportunity provides support for clinical researchers to develop independent careers in patient-centered and comparative effectiveness research, focusing on improving healthcare delivery for underserved populations in the U.S.