Federal Health Grants

The purpose of this program is to provide trauma-informed, evidence-based interventions to youth and young adults (not more than 25 years of age) who are at clinical high risk for psychosis. Award recipients are expected to use evidence-based intervention to: 1) improve symptomatic and behavioral functioning; (2) enable youth and young adults to resume age-appropriate social, academic, and/or vocational activities; (3) delay or prevent the onset of psychosis; and (4) minimize the duration of untreated psychosis for those who develop psychotic symptoms.

The purpose of the Mentored Research Scientist Career Development Award in Tobacco Regulatory Research (K01) is to provide support and protected time (three, four, or five years) for an intensive, supervised career development experience in biomedical, behavioral, and social science research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing and that will lead to research independence. Research projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP) as mandated by the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31.

NLM wishes to accelerate the availability of and access to secure, complete data sets and computational models that can serve as the basis of transformative biomedical discoveries by improving the speed and scope of the curation processes.NLM wishes to accelerate the availability of and access to secure, complete data sets and computational models that can serve as the basis of transformative biomedical discoveries by improving the speed and scope of the curation processes. This Funding Opportunity Announcement is focused on automating curation of biomedical digital assets in support of Goal 1. Objective 1.1 of the NLM Strategic Plan 2017-2027: An important research direction will develop strategies for curation at scale." The ability to re-use, integrate or add to existing data sets will open new avenues of opportunity and can speed discoveries that will improve health. But this promise will go unrealized without advances in automated and autonomous curation. Objective 1.2: Automatic, autonomous curation strategies will allow for operational efficiency as well as accelerate the speed of discovery Digital curation involves characterizing, annotating, managing, and preserving digital assets such as research data sets, computational and other types of models, reusable visualization tools, and other digital assets. Proficient curation of digital assets maximizes their reuse potential, mitigates risk of obsolescence, reduces the likelihood that their long-term value will diminish or be lost, and helps assure reproducibility of research. The evolving digital ecosystem supports data-driven biomedical discovery by providing access to large quantities of biomedical and health-related data, to computational models and to open source software and code. The scope, scale and heterogeneity of digital data alone are vast, ranging from genome sequences to biomedical images, from observational health findings to environmental measurements, from family histories to sensor readings from personal trackers. As the amount and complexity of digital assets continue to grow, manual curation will not scale to meet future needs. At the same time, as researchers make research data sets, models and other tools available for new uses or re-analysis, it is important to minimize duplication and simplify the process of finding, managing, visualizing and mining all types of digital assets. To help researchers who want to find, interoperate and use these data sources to make new discoveries, and to share their findings so others can build upon them, the purpose of this funding announcement is to encourage applications for new approaches that (1) increase the speed and assure quality and security of storage techniques, retrieval strategies, annotation methods, data standards, visualization tools and other advanced data management approaches and (2) improve our ability to make biomedical data and other digital research assets findable, accessible, interoperable and reusable (FAIR).

The United States Agency for International Development (USAID) plans to invest in a five-year cooperative agreement titled GH Social and Behavior Change (SBC) Activity to support countries in achieving desired improvements in health and development outcomes.The GH SBC Activity will build upon current USAID investments in SBC research and programming, including both global and bilateral projects, to guide integration of SBC evidence and theory in development programming, support generation and use of new learning, strengthen local technical and organizational capacity, and drive local leadership of SBC programming for better, broader, and more sustainable results. The project will fulfill a global leadership function within SBC, working through new and existing partnerships to create opportunities for locally-driven, innovative, and cost-effective SBC programs; systematic integration of SBC best practices within public and private health systems; and generating, synthesizing, and catalyzing the application of evidence-based and theory-informed SBC in diverse program settings to accelerate achievement of global health and development goals.The strategic objective of the project is to increase implementation of theory-informed, evidence-based, locally-led SBC programming. While focused primarily on health, the project may address SBC needs in other sectors, with particular attention to areas of potential complementarity such as environmental conservation, agriculture, food security, and nutrition. Within the health sector, the project will maintain a substantive but non-exclusive focus on family planning, reproductive health (FP/RH) and reproductive empowerment; malaria; and maternal, newborn, and child health (MNCH), with attention to emerging pandemic threats and other infectious diseases. Considerations of USAID priorities such as localization, gender integration, youth engagement/integration, health systems strengthening, the inclusion of LGBTQI+ people, the inclusion of people with physical and cognitive disabilities, engaging the voices, skills, and experiences of allincluding marginalized and underrepresented groups such as racial, ethnic, and Indigenous communities and climate change, will be a focus across the project.Please see the Full GH Social and Behavior Change (SBC) Activity RFA under the "Related Documents" tab.

Research shows that HIV care must increasingly address the management of individuals with multiple coexisting diseases (p.357) such as infectious and chronic diseases, mental health and behavioral disorders, food insecurity, substance use, etc. Since individual diseases do not exist in a vacuum, neither does the management, or burden of disease on community well-being. In response, syndemic theory and approaches are used to (1) increase the focus on co-occurring and interacting disease and social conditions that exacerbate health inequities, and (2) advance the evidence base for effective approaches to assess, monitor, and intervene with respect to these co-occurring and interacting factors for optimal outcomes in HIV treatment and care. The purpose of this project is to design, implement, and evaluate innovative comprehensive interventions part of an integrated treatment plan , using a syndemic approach to address co-occurring and interacting conditions of HIV, substance use disorder, intimate partner violence (IPV), and other social determinants of health that impact health outcomes of racial and ethnic minorities with HIV.

The purpose of the Pathway to Independence Award in Tobacco Regulatory Research (K99/R00) is to increase and maintain a strong cohort of new and talented independent investigators conducting research that will inform the development and evaluation of regulations on tobacco product manufacturing, distribution, and marketing. This program is designed to facilitate a timely transition of outstanding postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions

This funding opportunity provides financial support for small businesses to develop innovative products and services aimed at preventing, diagnosing, and treating Alzheimer's disease and related dementias, ultimately improving care for affected individuals and their families.

This grant provides funding for researchers to develop and test advanced imaging tracers that can help understand and treat mental health and neurodegenerative disorders in humans.

This funding opportunity provides financial support to jurisdictions with their own immunization information systems to improve vaccine tracking and ordering processes through a new integration with the CDC's Vaccine Tracking System.

The purpose of this initiative is to: 1.Support mining of SCORCH data to identify cell types, transcripts, enhancers, or transcriptional networks that play a role in HIV/ART or SUD molecular responses 2.Support functional validation studies (e.g. epigenomic or transcriptomic manipulation, high throughput secondary screening, etc.) to confirm or deny a biological role for data-mined cell types, transcripts, enhancers, or transcriptional networks in HIV/ART or SUD molecular responses 3.Provide foundational knowledge for understanding SUD and/or HIV/ART molecular mechanisms and to generate validated targets that could serve as a foundation for new SUD or HIV therapeutics (including NeuroHIV cognitive phenotypes)

The purpose of this supplemental funding is to strengthen organizational capacity to respond to the changing health care landscape and increase access to high quality family-centered HIV primary health care services for low income women, infants, children and youth (WICY) with HIV. The Health Resources and Services Administration’s (HRSA) Ryan White HIV/AIDS Program (RWHAP) Part D funds outpatient family-centered primary and specialty medical care for low-income women, infants, children, and youth with HIV. Part D funding also may be used to provide support services to people with HIV and their affected family members. The Enhancing HIV Care of Women, Infants, Children and Youth: Building Capacity through Communities of Practice program is a platform for RWHAP Part D recipients to increase the delivery of evidence-based interventions, evidence-informed interventions, and emerging interventions that enhance client outcomes; increase the skill level of the HIV workforce providing care and treatment to women, infants, children, and youth; and involve partner collaboration for dissemination of best practices. During the four-year initiative, which began in fiscal year (FY) 2023, the Communities of Practice are focusing on three areas: ■ Pre-conception counseling, including sexual health (2023–2024) ■ Trauma-informed care (2024–2025) ■ The transition from youth services to adult care (2025–2026)

This funding opportunity is designed to support researchers exploring how RNA modifications affect brain aging and contribute to Alzheimer's disease and related dementias.

The National Institute of Neurological Disorders and Stroke (NINDS), intends to publish a reissue Notice of Funding Opportunity (NOFO) to solicit applications for innovative, interactive research to answer significant scientific questions that are important for the mission of NINDS, via a synergistic collaboration between outstanding scientists who might not otherwise collaborate. The program project grant is designed to support research in which the funding of several interdependent highly meritorious projects as a group offers significant scientific advantages over support of these same projects as individual research grants.. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in April 2024 with an expected application due dates in May and September 2024. NINDS will not have any receipt dates after September 2024, thus ending the program. This NOFO will utilize the P01 activity code. Details of the planned NOFO are provided below.

This funding opportunity supports U.S.-based organizations in implementing and sustaining effective strategies to prevent substance misuse and use disorders, particularly targeting individuals at risk but not yet diagnosed with a substance use disorder.

The goal of this concept is to support exploratory research and preliminary interventions to address the interrelated and compounding contextual factors that contribute to substance use and HIV risk among sexual trafficking survivors. This would be accomplished through research that builds new interventions and models of care that can effectively engage ST survivors in care for SUD, HIV, trauma, and other mental health outcomes and addresses key structural and social determinants of health that contribute to risk for ST as well as barriers to and facilitators of escaping continued exploitation.

This funding opportunity supports academic and research institutions in implementing innovative programs to improve research rigor and transparency in neuroscience, ultimately enhancing the quality and reliability of scientific findings.

This funding opportunity supports projects that integrate mental health care into healthcare and community settings in low- and middle-income countries, aiming to improve access and quality of mental health services while building local research capacity.

This funding opportunity supports researchers in developing innovative small animal and human cellular models to study the complex interactions between the central nervous system and the immune system in individuals living with HIV who are on antiretroviral therapy.

This grant provides funding to organizations in South Africa to implement targeted HIV prevention and care programs for high-risk populations, including youth, in various community settings such as schools and workplaces.

This funding opportunity supports the development of innovative tools and systems that help individuals collect and understand their health data to make informed decisions about their health.