Federal Health Grants

The purpose of this program is to provide training and technical assistance (TTA) to domestic public and private non-profit entities that provide or support services intended for people who are experiencing challenges related to a substance use or co-occurring condition. Recipients will be expected to develop, implement, and maintain a TTA center that aligns with SAMHSA’s National Recovery Agenda.2 TTA activities will range from outreach and engagement to promotion of recovery and peer support. The vehicles used to deliver the TTA vary along a continuum from universal TTA (broad in scope; limited in depth, such as webinars), to more specific group-focused (such as learning collaboratives), to intensive (limited in reach, but deeper in-depth, such as onsite regular consultation or policy academies). The recipient will also partner with national, state, and local organizations and experts, including peer-run organizations and experts with lived experience to achieve required activities.

"Fluctuating cognition can occur in many types of dementia and is a core clinical feature of Dementia with Lewy Bodies. Cognitive fluctuations can last from seconds to days, are unpredictable (e.g., do not just occur in the evenings, as with sun-downing), and are associated with poor daily functioning for the patient. A number of small studies have suggested that cognitive fluctuations in subjects with dementia may be related to epileptiform discharges and impaired oscillatory activity on EEG, but it is not clear that these are the only factors involved in patient populations that often experience dysautonomia, orthostasis, and sleep disturbances. The etiology of cognitive fluctuations may be multi-factorial and may vary in different dementia populations. Understanding the physiology related to cognitive fluctuations is a critical next step to the development of treatment approaches and improving quality of life for these patients. This initiate would encourage research that will better characterize the physiology responsible for cognitive fluctuations in ADRD populations. Given their variable appearance and time course, it is anticipated that wearable digital devices will be important for capturing fluctuations in a timely fashion, and applicants should consider incorporating those device(s) capable of acquiring the relevant data to support the hypothesized mechanism(s). Applicants may focus on assessing multiple mechanisms in a specific ADRD population, or may chose to compare mechanisms across multiple types of ADRDs. "

This funding opportunity supports research on the ethical, legal, and social implications of human genetics and genomics, particularly focusing on diverse perspectives and community engagement.

This funding opportunity supports early-stage postdoctoral researchers in cancer research by providing resources for structured training and professional development to advance their scientific careers.

(Reissue PAR-21-056) The purpose of this Program Announcement (PAR) is to enable analytical validation of strong candidate biomarkers for neurological diseases and conditions. Specifically, the goal of this PAR is to enable the rigorous validation of analytical methods for biomarker measurements, including evaluation of the detection method, its performance characteristics, and the optimal conditions that will generate reproducibility and accuracy consistent with FDA guidelines. This PAR assumes that 1) a candidate biomarker has already been identified, 2) detection method technology has already been developed, and 3) the research and/or clinical need and potential context of use has been identified.

This grant provides funding for researchers to study how HIV and substance use disorder affect brain cell function, with the goal of uncovering new treatment strategies for individuals facing these combined challenges.

This funding opportunity supports researchers in conducting multi-site clinical trials to investigate the effects of natural products, such as botanicals and dietary supplements, on health, requiring a comprehensive plan for trial management and data analysis.

The purpose of the NINDS Postdoctoral Mentored Career Development Award is to support the ability of outstanding, mentored postdoctoral researchers to develop a potentially impactful research project with a comprehensive career development plan that will enable them to launch an independent research program. Candidates are encouraged to apply for support from this NINDS K01 any time between the second through fourth year of cumulative mentored postdoctoral research experience, and may be supported by this NINDS K01 within the first 6 years of cumulative postdoctoral research experience. Because the completion of a strong, well-planned, thorough career development plan, in addition to development of an impactful research project, is a critical aspect of this K01, applications are strongly encouraged early in the postdoctoral eligibility window. By the end of the proposed K01 award period, the candidate should be poised to begin an independent research career with a well-developed, impactful research project and the expertise required to become a leader in the field.This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development.

This funding opportunity provides financial support to various government and nonprofit organizations to improve access to medical forensic examinations for sexual assault survivors through the development and expansion of specialized programs and services.

This funding opportunity provides $2 million to organizations working globally to improve the safety and security of biological research, particularly in high-containment laboratories and through policy development, with a focus on countries in Latin America and Asia.

This Notice of Funding Opportunity (NOFO) aims to support research on interdisciplinary population approaches to increasing awareness of the relationship between alcohol and cancer risk, understanding and changing social norms related to alcohol consumption, developing and/or evaluating alcohol policy approaches, and the development, testing, and implementation of population-level interventions to reduce alcohol-related cancer risk. Applications that address multiple levels of consumption, such as moderate and heavy drinking, are of particular interest, as well as those focusing on alcohol use disorder (AUD) from the perspective of cancer prevention and control. Proposals addressing understudied areas are encouraged, as is attention to underrepresented minority (URM) populations experiencing cancer and alcohol-related disparities such as American Indian, Alaskan Native, and sexual and gender minority populations.

This funding opportunity supports researchers conducting multisite clinical trials and observational studies focused on women, children, pregnant and lactating individuals, and persons with disabilities, utilizing NICHD's established network infrastructure.

This funding opportunity supports doctoral candidates conducting research on maternal and child health using a large dataset to explore the impact of early environmental exposures on child health outcomes.

The primary goal of this Institutional Research Training Grant is to provide short-term training for medical students to obtain necessary aging research experiences and technical expertise and skills early during their education to encourage them to pursue careers in research. Other health professional students may also benefit from such short-term training and are eligible when research training is a minor part of, or nonexistent in, their doctoral program. This Notice of Funding Opportunity Announcement (NOFO) does not allow appointed trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

This 5-year projects purpose is to continue collaboration with counterparts in China to reduce the threat of infectious disease transmission, in China, the U.S. and the world. This collaboration contributes to enhancing the technical collaboration, scientific exchange, and effective communication to promote health through trusted and robust partnerships between U.S. CDC and counterparts in China. The program has three broad goals: 1) strengthen public health systems and workforce capacity, 2) decrease the burden of TB, and 3) reduce influenza morbidity and mortality and enhance preparedness for pandemic threats. Activities may include joint investigations and monitoring of disease outbreaks, piloting innovative public health interventions, translating programmatic success to practice and policy, working in third countries to jointly respond to a public health emergency, and promoting rapid and transparent dissemination of public health data. This collaboration strives to leverage the expertise in China to share knowledge and evidence-based science for a bi-lateral exchange that mutually benefits the U.S. and China. By identifying governmental, non-governmental, multilateral, and private sector organizations in China, the partnership builds sustainable expertise and capacity in global health security and public health systems. Depending on funding availability and priorities, the specific infectious disease entities to be addressed can change over the period of performance.

This funding opportunity provides financial support for researchers to analyze existing oral health data or develop new statistical methods to improve understanding of dental and craniofacial issues.

This funding opportunity provides financial support for researchers to quickly investigate the immediate health impacts of unexpected environmental events, such as disasters or policy changes, by collecting critical data in partnership with affected communities.

The Appalachian Region Healthcare Support Program provides technical assistance (TA) to help rural healthcare organizations, including critical access hospitals (CAHs), small rural hospitals, rural health clinics, tribal healthcare facilities, and other healthcare organizations located in the rural counties served by the Appalachian Regional Commission (ARC) with planning and implementing health care service improvements. The goal of this program is to strengthen healthcare delivery in rural areas of the Appalachian Region by improving financial and operational performance as well as the quality of care in rural healthcare organizations. The TA provider funded under this cooperative agreement will work with individual healthcare organizations to meet the following program objectives: Provide objective analysis and assessment of healthcare organizations financial status, market share, quality indicators, locally available human services, and gaps in services so that organizations can make actionable change; Identify clinical areas where expansion of services within a rural healthcare organization would meet local need, keep health care services available locally, and build capacity to improve financial and operational performance as well as quality of care. Support healthcare organizations in implementing best practice recommendations prioritized in TA action plans. For purposes of this notice of funding opportunity, rural healthcare organization is a health care organization located in a rural area in the Appalachian Region. A healthcare organization includes critical access hospitals, small rural hospitals, rural health clinics, tribal healthcare facilities, and other healthcare organizations. To determine if a health care organization is located in a rural area, visit https://data.hrsa.gov/tools/rural-health. To determine if a county is in the Appalachian Region, visit https://www.arc.gov/appalachian-counties-served-by-arc.For more details, see Program Requirements and Expectations.

Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

This grant provides funding for collaborative research teams to develop and test strategies that address and reduce racial and ethnic disparities in substance use and addiction, prioritizing community-driven issues.