Grants for Native American tribal organizations - Health

This Funding Opportunity Announcement (FOA) supports applications to develop and implement a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials including efficacy, comparative effectiveness, pragmatic and/or implementation research clinical trials. Trials for which this FOA applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This FOA will utilize a bi-phasic, milestone-driven cooperative agreement mechanism of award and runs in parallel with a companion FOA that encourages applications for a collaborating Data Coordinating Center (PAR-22-NNN). The objective of the CCC application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, subject recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. Both a CCC application and a collaborating Data Coordinating Center (DCC) application must be submitted on the same application due date for consideration by NHLBI. Applicants are strongly encouraged to contact the appropriate Scientific/Research contact prior to submitting an application.

This funding opportunity supports research projects that investigate how mitochondrial function affects brain health and immune aging in individuals living with HIV and substance use disorders, aiming to identify new therapeutic strategies.

This funding opportunity is designed to support the establishment of research centers that provide essential resources and infrastructure for advancing studies on rheumatic diseases, encouraging collaboration among researchers and institutions.

This Funding Opportunity Announcement (FOA) encourages grant applications from investigators interested in conducting basic, mechanistic research into the biological/genetic causes of cancer health disparities. These research project grants will support innovative studies designed to investigate biological/genetic bases of cancer health disparities, such as (1) mechanistic studies of biological factors associated with cancer health disparities, including those related to basic research in cancer biology or cancer prevention strategies, (2) the development and testing of new methodologies and models, and (3) secondary data analyses. This FOA is also designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research who can expand available resources and tools, such as biospecimens, patient derived models, and methods that are necessary to conduct basic research in cancer health disparities.

This funding opportunity provides financial support for projects that promote healthy relationships and marriage education for adults, with a focus on enhancing family stability and economic well-being.

This grant provides funding for innovative researchers to explore groundbreaking ideas that could transform the prevention and treatment of HIV/AIDS, particularly among individuals with substance use disorders.

This grant provides funding for multidisciplinary teams, including researchers, industry partners, and patient advocates, to develop innovative genetic therapies for rare hereditary diseases affecting millions of Americans, particularly children, by creating safe and effective one-time treatments.

The "Blueprint MedTech Translator" grant aims to fund researchers to develop and test therapeutic and diagnostic devices for nervous or neuromuscular system disorders, with support for clinical trials, safety testing, design verification, and regulatory approvals, while also providing access to expert consultants and specialized research organizations.

The Black, Indigenous, and People of Color Fund aims to promote equity for Native American, Latino, African, Arab, and Asian communities in Maine through leadership investment, policy change, and alleviating race-based disparities. The fund focuses on organizations with BIPOC leadership and involvement, prioritizing racial equity, health, leadership development, and economic opportunities. It offers two-year general support grants of up to $10,000 per year, with the first grants awarded in 2024. Organizations must be based in Maine and meet specific community service criteria to qualify. Grant renewed every year. Grant Annual opening/closing deadlines: November 15th to February 15th

The Statewide Family Network Program aims to enhance the capacity of statewide mental health family-controlled organizations. These organizations engage with family members and primary caregivers who are raising children, youth, and young adults with serious emotional disturbance (SED) and/or co-occurring disorders (COD). The program supports family-driven, trauma-informed, culturally relevant, holistic, and resiliency-oriented approaches. Eligible applicants include states and territories, political subdivisions of states, Indian tribes or tribal organizations, health facilities, and other public or private non-profit entities. Applications are due by April 8, 2024, with awards expected to start by September 30, 2024. The grant provides up to $120,000 per year for up to three years, with a total available funding of $1,116,777. Nine awards are anticipated. Cost sharing or matching is not required.

The objective of this research proposal is to develop physiologically based pharmacokinetic (PBPK) model-based mechanistic in vitro in vivo correlations (IVIVCs) for two major types of long acting injectables (LAIs) such as crystalline suspensions and polymer-based implants by considering their distinct characteristics. The goal of the project is to develop a bottom-up mechanistic PBPK model for these two LAI categories by accounting for the influence of critical formulation attributes of each LAI drug product type to predict its in vivo release mechanism. The model formulation parameters and relevant physiology should be informed with suitable in vitro and in vivo experiments. A suitable preclinical animal model can be used to validate the PBPK model based IVIVCs for both LAI suspensions and polymer based implants. The use of PBPK modelling provides a unique opportunity to understand how the physicochemical properties of drug molecules/polymer, implant specific properties, critical formulation attributes, and physiology, among other things, influence the in vivo release mechanisms of LAI drug products and their disposition characteristics. Moreover, once developed, a mechanistic PBPK model can help to define the 'safe space' for critical formulation attributes relevant to the reference listed drug (RLD) product, explain sources of PK variability and extrapolate predictions to human subjects by leveraging animal model data and by accounting for species-specific physiological differences.

This funding opportunity supports research projects that investigate the relationship between HIV and aging, focusing on improving health outcomes for older adults living with HIV, particularly in diverse and underserved populations.

The National Academy of Sciences Gulf Research Program is investing $50 million in the Gulf Futures Challenge to fund projects addressing critical challenges in the Gulf region. The Challenge aims to discover and promote innovative and transformative solutions by leveraging the talent and knowledge of the Gulf's people. The competition focuses on three main areas: energy transition, environmental change along the coast, and healthy and resilient communities. Up to ten finalists will receive up to $1 million in project development support, with two finalists awarded $20 million each to implement their solutions. Eligible applicants include nonprofits, state, local, and tribal governments, and academic institutions from Alabama, Florida, Louisiana, Mississippi, or Texas, with projects located within 100 miles of the Gulf coastline. The registration deadline is August 20, 2024, and the application deadline is September 20, 2024.

This funding opportunity supports research projects that develop and implement effective tobacco use treatment services for cancer survivors across diverse clinical settings, with a focus on equitable access and reducing health disparities.

This funding opportunity supports graduate students from diverse backgrounds in neuroscience to complete their Ph.D. and transition into postdoctoral research positions, promoting career development and research training.

This funding opportunity supports U.S. institutions training addiction medicine and psychiatry fellows to improve substance use disorder treatment in underserved and rural communities.

This funding opportunity provides financial support for early-career researchers from diverse backgrounds to develop their skills in cancer research under the mentorship of experienced scientists, without leading independent clinical trials.

This grant provides funding for research to develop and test combined neuromodulation and behavioral treatment strategies for individuals with Stimulant Use Disorder, particularly targeting those with vulnerable traits like low executive function and impulsivity.

This funding opportunity supports research to improve stem cell-derived islet cells for transplantation therapies, targeting interdisciplinary collaborations among scientists and institutions focused on diabetes and cell biology.

The "Limited Competition: NCI National Clinical Trials Network - Network Group Statistics and Data Management Centers" grant is designed to provide financial support to current awardees for maintaining centers that offer statistical expertise and data management for large-scale, multi-center oncology clinical trials aimed at advancing cancer treatment through precision medicine approaches.