Grants for Small businesses - Health

This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change.Considering the current healthcare challenges that we face today, the goal of achieving better health outcomes is a moving target that requires daring and adaptable solutions. HSF awardees will develop innovative technologies, tools, and platforms that can be applied to a broad range of diseases. The following interest areas define the ground-breaking research we seek to support:Breakthrough Technologies: Paradigm shifting technologies that will change how we approach the diagnosis, treatment, and impact of diseases and conditions. Novel approaches to improve maternal and fetal medicine, decrease maternal morbidity and mortality during birth, and the post-partum period. Efforts should include new technology to monitor, detect, and/or treat maternal and/or fetal complications with less invasive and traumatic methods. Foundational advances in genetic, epigenetic, cellular, tissue, and organ replacement therapies that enable personalized medical interventions at scale in a manner that is accessible, cost-effective, and designed to impact the communities of greatest need. Interventions that target and reverse disease pathogenesis and/or enhance plasticity to address diseases of the nervous, neuromuscular, skeletal, lymphatic, cardiovascular, and other organ systems. Novel approaches to diagnose and treat diseases of the lymphatic system, particularly rare diseases, with a focus on the effects of genetic expression in the lymphatic system and/or models demonstrating the relationship between lymphatic dysfunction and health and disease.Transformative Tools: Novel, agile solutions that will move from bench to bedside quickly, facilitating revolutionary advances in medical care. Development of tools that counter idiosyncratic, off-target, or chronic effects of medicines that are commonly used or that are being used experimentally to treat or prevent disease. Development of bionics to restore sight, hearing, taste, or smell. Site-selective neuromodulation to regulate specific physiological functions and treat chronic health conditions such as inflammation, pain, and metabolic or endocrine disorders. Synthetic biology approaches to diagnosing, treating, and/or curing a multitude of diseases. Novel physics and/or chemistry-based approaches to improve imaging that reduces cost, increases availability, expands capability, improves resolution, reduces exposure to radiation, and accommodates pediatric patient populations. Integrated sensing and delivery devices for treating and diagnosing chronic health conditions, including mental health conditions or substance use disorders. Miniaturization of complex hardware to enable broader access to pediatric and other patient populations, as well as portability, such as diagnostic, treatment, imaging, or other devices.Platform Systems: Adaptable, multi-application systems and technologies that are reconfigurable for a wide variety of clinical needs Novel molecular platform approaches, including the modulation of host systems, delivery to targets with spatial and temporal precision, and mitigation of off-target effects to accelerate interventions that dramatically improve health outcomes. New approaches to accelerate and routinize mammalian and microbial cellular engineering to enable next generation therapeutic applications, develop multiscale interventions, and automate hypothesis generation and discovery to expand those applications to disease states in which cellular therapies have not traditionally been employed. Innovative approaches at the intersection of artificial intelligence, high performance computing (including quantum computing) and biological systems, including enabling de novo design of biomolecules with entirely new phenotypes.Other high-quality submissions that propose revolutionary technologies that meet the goals of HSF will be considered even if they do not address the topics listed above.Proposals are expected to use innovative approaches to enable revolutionary advances in medicine and healthcare, and the science and technology underlying these areas. While approaches that are disease agnostic are encouraged, ARPA-H welcomes proposals that bring radically new insights to address specific diseases including, but not limited to, cancer, diabetes, neurological diseases, pediatric and maternal/fetal health, infectious diseases, and cardiovascular disease.Specifically excluded are proposals that represent an evolutionary or incremental advance in the current state of the art or technology that has reached the clinical trial stage. An example of this type of proposal might include the request to fund clinical trials of an otherwise developed product. Additionally, proposals directed towards policy changes, traditional education and training, or center coordination, formation, or development, and construction of physical infrastructure are outside the scope of the ARPA-H mission.

This funding opportunity supports multidisciplinary research aimed at improving the understanding and treatment of asthma and allergic diseases, inviting applications from various institutions and organizations involved in clinical and translational research.

This funding opportunity provides financial support for researchers to plan and prepare for clinical trials focused on infectious, immunologic, and allergic diseases, ensuring they have the necessary resources and documentation for future trial implementation.

This funding opportunity supports research initiatives aimed at preventing community violence among youth and young adults, particularly those addressing racial and ethnic disparities, with grants available to governments, educational institutions, and non-profits.

This funding opportunity supports postdoctoral researchers in biomedical and behavioral fields, providing mentorship and resources to help them develop into independent scientists.

This funding opportunity provides financial support to organizations working to improve HIV prevention and treatment for Haitian migrants and their descendants in the Dominican Republic, focusing on overcoming barriers to healthcare access and enhancing treatment outcomes.

This grant provides funding to support career development and mentoring for junior faculty in clinical rehabilitation fields, helping them transition to independent research roles that improve the health and quality of life for individuals with chronic disabilities.

The Milwaukee Fresh Food Access Fund (FFAF) offers grants to increase access to healthy food in underserved areas. Eligible projects: Attract grocery stores or mobile markets to underserved neighborhoods Increase fresh food options in corner stores or other retail outlets Increase availability of local food Meet dietary needs of specific populations Improve transportation to grocery stores and farmers markets Eligible uses of grants: Equipment for storing/preparing healthy food Furniture, fixtures, and inventory for healthy food businesses Building improvements for food retail or production Vehicles to transport healthy food Improvements to fresh food retail stores Community garden construction or equipment Soft costs essential for other eligible uses Eligible applicants: Non-profits with 501(c)3 status For-profit businesses Maybe other entities (case-by-case) Application process: Questions due to [email address removed] by 4pm on May 10, 2024 Answers and info posted by May 15, 2024 at www.milwaukee.gov/ffaf Applications reviewed by a panel Decisions are final Grant renewed every year.

This grant provides funding for researchers to investigate the genetic and environmental causes of structural birth defects, promoting collaboration between scientists and clinicians to improve prevention and treatment strategies.

This funding opportunity provides financial support for eligible organizations to research and analyze the incidence of epilepsy among children in the U.S., focusing on disparities and risk factors using advanced data science techniques.

This grant provides funding for research on behavioral sleep interventions aimed at improving sleep and mental health outcomes for adolescents and young adults, particularly those from underserved populations.

This funding opportunity provides financial support for research sites to study Type 1 diabetic nephropathy by recruiting patients, conducting kidney biopsies, and collecting data to identify new treatment targets and improve precision medicine approaches.

This funding opportunity supports a central coordinating center that will enhance collaboration and provide resources for research in nonmalignant hematology, particularly aimed at fostering the development of junior investigators and innovative projects across multiple institutions.

This funding opportunity provides financial support for research on the role of inflammasomes in the brain related to HIV and substance use disorders, targeting innovative studies that explore their impact on inflammation and neurocognitive health.

This grant provides funding for interdisciplinary research teams to explore the ethical implications of new neurotechnologies and brain science advancements, focusing on issues like data privacy, informed consent, and public attitudes toward brain research.

The "Closing inequities in HIV Prevention, Care and Treatment among key populations in Burkina Faso Activity (Equity KP Burkina Faso)" grant aims to support local entities in Togo and Burkina Faso in providing quality HIV services, improving the environment for key populations and their partners, and enhancing monitoring and sustainability efforts for HIV epidemic control by 2030.

This funding opportunity supports organizations conducting large-scale clinical trials focused on innovative treatments for vision disorders, ensuring effective management and oversight of the research process.

This funding opportunity supports neuroscience graduate students in completing their doctoral studies and transitioning to postdoctoral research positions, fostering their development into independent investigators in the field.

This funding opportunity supports innovative researchers and teams in the U.S. who propose groundbreaking projects that could significantly advance biomedical and social sciences, without the need for preliminary data.

This program provides funding and mentorship to early-career U.S. faculty researchers to develop innovative technologies that address national security challenges.