Grants for Public housing authorities - Income Security and Social Services

These projects will be funded under the Projects of National Significance (PNS) within the Developmental Disabilities Assistance and Bill of Rights Act. The project will focus on achieving economic security and mobility for individuals with intellectual and developmental disabilities. The purpose of the project may include providing aid to transition youth with intellectual and developmental disabilties, funding employment and postsecondary education opportunties, and / or assiting with assistive technology devices that may needed to help meet employment goals. Overall, these projects will create opportunities for individuals with developmental disabilities to directly and fully contribute to, and participate in, all facets of community life; and support the development of national and State policies that reinforce and promote, with the support of families, guardians, advocates, and communities, of individuals with developmental disabilities, the self-determination, independence, productivity, and integration and inclusion in all facets of community life of such individuals.Projects funded under this announcement will work toward one or more of the following performance measures:Outcome Measure 1: Number of policies changed to improve the experience of people with ID/DD and their families Output Measure 1.1: Number of people who participated in policy advocacy activities Output Measure 1.2: Number of trainings about policy implemented Output Measure 1.3: Number of policy products created Output Measure 1.4: Number of times policy products were sharedOutcome Measure 2: Number of people with ID/DD and their families who report new or increased leadership roles Output Measure 2.1: Number of tools and resources created related to leadership by people with I/DD and their families Output Measure 2.2: Number of tools and resources shared related to leadership by people with I/DD and their families Output Measure 2.3: Percent of people with I/DD and their families who reported learning new leadership skills Output Measure 2.4: Number of people with I/DD and their family members who train or mentor others as leaders or advocatesOutcome Measure 3: Percent of people with ID/DD and their families who reported increased knowledge of supports needed to help them achieve the life they want Output Measure 3.1: Number of trainings held to increase knowledge of supports available to help achieve a desired life Output Measure 3.2: Number of resources created to increase knowledge of supports available to help individuals achieve the life they want Output Measure 3.3: Number of resources shared to increase knowledge of supports available to help individuals achieve the life they wantOutcome Measure 4: Number of data resources accessed Output Measure 4.1: Number of data resources created Output Measure 4.2: Number of activities to disseminate data

This grant provides funding for researchers to develop and validate innovative tools that improve the analysis of brain circuits and cellular interactions, with a focus on targeting specific cell types and circuits across various species.

This funding opportunity provides financial support for research organizations to establish expert panels that will evaluate and curate genomic variants linked to important diseases, enhancing clinical understanding and treatment options.

This grant provides access to specialized preclinical services for researchers developing non-hormonal contraceptives and reproductive health therapies, focusing on innovative approaches to address various reproductive health conditions.

This funding opportunity supports innovative research to develop new prevention technologies that provide effective contraception and protection against HIV and STIs for diverse populations, including adolescents and high-risk individuals.

Reissue of RFA-MH-22-115 to comply with DMSP policy. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervention with novel cell and circuit specific tools will require extensive focused research designed to remove barriers to delivery of gene therapies. In addition to identification and removal of barriers, the need to specifically target dysfunctional circuitry poses additional challenges. Neuroscience has experienced an impressive influx of exciting new research tools in the past decade, especially since the launch of the BRAIN Initiative. However, the majority of these cutting edge tools have been developed for use in model organisms, primarily rodents, fish and flies. These cutting edge tools, such as viral delivery of genetic constructs, are increasingly adaptable to large brains and more importantly are emerging as potential human therapeutic strategies for brain disorders. A pressing need to develop tools for use in large brains, more directly relevant to the human brain is the focus of this initiative. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application.

This funding opportunity provides access to a specialized facility for researchers developing innovative, safe, and effective non-hormonal contraceptive methods for men and women, supporting preclinical studies necessary for future clinical trials.

This funding opportunity supports interdisciplinary research teams to explore how medical devices can effectively relieve chronic pain while minimizing addiction risks.

The grant titled "BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 Clinical Trials Not Allowed)" is designed to fund exploratory research projects that use innovative methods to understand how brain circuit activity influences mental experiences and behavior, with successful results potentially leading to further research projects.

The "BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination" grant aims to support the distribution, integration, and minor improvement of existing neuroscience research tools and technologies, as well as user training, to help achieve the goals outlined in the "BRAIN 2025: A Scientific Vision" report.

Reissue of RFA-MH-22-220 to comply with DMSP. This FOA supports the development of software to visualize and analyze the data as part of programs of building the informatics infrastructure for the BRAIN Initiative. Other informatics programs include developing data standards that are needed to describe the new experiments that are being created by or used in the BRAIN Initiative ( RFA-MH-19-146 ), and creating the data infrastructures that will house the data from multiple experimental groups ( RFA-MH-19-145 ). Each of the programs is aimed at building an infrastructure that is used by a particular sub-domain of experimentalists rather than building a single all-encompassing informatics infrastructure now. Building the infrastructure one experimental area at a time will ensure that the infrastructure is immediately useful to components of the research community. As our understanding of the brain improves, it may be possible to create linkages between these various sub-domain specific informatics programs. Investigators of the informatics programs should keep that goal in mind and build for the future even though the current efforts are more limited in scope.

The "Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes" grant aims to fund research projects that prepare for clinical trials in rare diseases by developing effective strategies for testing potential treatments or diagnostics, improving success rates with robust biomarkers and assessment measures, or by understanding the progression of a rare disease to design future clinical trials.

The "Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes" grant aims to fund research projects that prepare for clinical trials in rare diseases by developing effective strategies for testing potential treatments or diagnostics, improving success rates with robust biomarkers and assessment measures, or by understanding the progression of a rare disease to better design future clinical trials.

The purpose of the The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Fellows (F32) program is to enhance the research training of promising postdoctorates, early in their postdoctoral training period, who have the potential to become productive investigators in research areas that will advance the goals of the BRAIN Initiative. Applications are encouraged in any research area that is aligned with the BRAIN Initiative, including neuroethics. Applicants are expected to propose research training in an area that clearly complements their predoctoral research. Formal training in analytical tools appropriate for the proposed research is expected to be an integral component of the research training plan. In order to maximize the training potential of the F32 award, this program encourages applications from individuals who have not yet completed their terminal doctoral degree and who expect to do so within 12 months of the application due date. On the application due date, candidates may not have completed more than 12 months of postdoctoral training.

This grant provides funding to U.S. higher education institutions to support predoctoral training programs in neuroscience, focusing on developing a diverse group of skilled scientists through comprehensive research training and mentorship.

Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

The purpose of this Funding Opportunity Announcement (FOA) is to invite R21 applications on chronic conditions understudied among women and/or that disproportionately affect populations of women who are understudied, underrepresented, and underreported in biomedical Research should align with Goal 1 of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research "Advancing Science for the Health of Women." The awards under this FOA will be administered by NIH ICs using funds that have been made available through the Office of Research on Womens Health (ORWH) and the scientific partnering Institutes and Centers across NIH.

The purpose of this Funding Opportunity Announcement (FOA) is to invite R01 applications on chronic conditions understudied among women and/or that disproportionately affect populations of women who are understudied, underrepresented, and underreported in biomedical Research should align with Goal 1 of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research "Advancing Science for the Health of Women." The awards under this FOA will be administered by NIH ICs using funds that have been made available through the Office of Research on Womens Health (ORWH) and the scientific partnering Institutes and Centers across NIH.

This funding opportunity supports innovative research projects aimed at improving drug safety and effectiveness for pregnant and lactating individuals, children, and those with disabilities, encouraging collaboration among various institutions and disciplines.